Anatomic and Functional Connectivity Relationships in Autistic Children

April 2018
Conference: American Academy of Neurology At: Los Angeles, California, USA
Project: Autism
Philip A Defina
Yanin Machado
Mauricio Chinchilla
Yazmina Machado
…and others.

ABSTRACT: Objective: To determine the relationship between the anatomic (AC) vs. functional (FC) connectivity, considering short-range and long-range brain networks. Background: In a recent published paper (Machado et al., 2013), we showed that in autistics studied with video without audio tasks vs. video without audio tasks, tended to show lower coherence values in the right hemispheres, suggesting an impairment of visual and auditory sensory integration in autistics. Design/Methods: Aanatomic connectivity was assessed by the DW-MRI technique and functional connectivity by EEG coherence calculation, in three experimental conditions: basal, watching a popular cartoon with audio (V-A), and with muted audio track (VwA). Results: For short-range connections, basal records, statistical significant correlations for all EEG bands in the left hemisphere were found, meanwhile in the right hemispheres no significant correlation for fast EEG frequency bands were noticed. For the V-A condition, significant correlations mainly diminished for the left hemisphere; for the right hemisphere again no significant correlations for the fast EEG frequency bands were found. For the VwA condition, significant correlations for the rapid EEG frequencies mainly disappeared for the right hemisphere. For long-range connections, basal records, similar correlations were found for both hemispheres. For the right hemisphere significant correlations incremented to all EEG bands for the V-A condition, but these significant correlations disappeared for the fast EEG frequencies in the VwA condition. Conclusions: It appears that in a resting-state condition, AC is better associated with functional connectivity for short-range connections in the left hemisphere. V-A experimental condition enriches AC and FC association for long-range connections in the right hemisphere. This might be related to an effective connectivity improvement due to visual and auditory stimulation. An impaired audiovisual interaction in the right hemisphere Study Supported by: NA

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