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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230512T110000
DTEND;TZID=America/Vancouver:20230512T120000
DTSTAMP:20231124T144003
CREATED:20230109T181911Z
LAST-MODIFIED:20230404T190800Z
UID:10236-1683889200-1683892800@www.centreforbrainhealth.ca
SUMMARY:Dr. Christopher Pack: Cortical basis of visual learning\, fast and slow
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHubel & Wiesel famously showed that the adult visual cortex changes very little with experience\, and yet we are capable of learning to recognize new faces and places throughout our lives. I will describe recent work that examines the brain changes that accompany learning of a new visual stimulus or visual behaviour. Most changes occur slowly\, over days or weeks\, and these involve altered connections between visual cortex areas and higher-level cortical regions. Under appropriate conditions\, we can observe learning that is very fast\, on a time-scale of minutes\, despite involving similar brain circuits. I will discuss potential applications to visual perception in healthy subjects and rehabilitation following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-christopher-pack/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230505T110000
DTEND;TZID=America/Vancouver:20230505T120000
DTSTAMP:20231124T144003
CREATED:20220604T014752Z
LAST-MODIFIED:20230411T201632Z
UID:9074-1683284400-1683288000@www.centreforbrainhealth.ca
SUMMARY:Dr. Yingxi Lin: Active Neuronal Ensembles
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHow are transient experiences converted into long-lasting memories? How do experiences modify behaviors? How do similar experiences elicit drastically different behavioral responses in the healthy and disease states? These are some of the questions that drive the research in my lab. We particularly focus on the mechanisms underlying the reconfiguration of neural circuits following sensory and behavioral experiences that leads to functional adaptation. While we know in many cases the brain regions that are involved\, the identity of the neurons that encode the information and the particular information that is processed are not easy to determine with standard molecular or systems approaches. To overcome these challenges my lab has developed a new set of genetic tools that have enabled us to genetically identify neuronal ensembles activated by sensory and behavioral experiences\, uncover essential circuit components involved in different aspects of learning and memory\, and explore the mechanisms by which learning is specifically coupled to synaptic changes on these ensembles to achieve behavioral adaptation. My talk will highlight both published and ongoing studies in my lab. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-yingxi-lin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230428T110000
DTEND;TZID=America/Vancouver:20230428T120000
DTSTAMP:20231124T144003
CREATED:20220426T223214Z
LAST-MODIFIED:20230127T185916Z
UID:8926-1682679600-1682683200@www.centreforbrainhealth.ca
SUMMARY:Dr. Stuart Trenholm: A day in the life of a blind mouse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIt is well established that after vision loss\, capabilities of the other sensory systems can be enhanced. However\, particularly in animal models of vision loss\, little has been done to examine how vision loss leads to alterations in the ‘blind brain’\, and how these changes affect an animal’s behavior. Here I will discuss our recent work describing changes in neuronal activity and animal behaviour in mice following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-stuart-trenholm/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230421T110000
DTEND;TZID=America/Vancouver:20230421T120000
DTSTAMP:20231124T144003
CREATED:20221025T210816Z
LAST-MODIFIED:20230411T233932Z
UID:9816-1682074800-1682078400@www.centreforbrainhealth.ca
SUMMARY:Dr. Jesse Jackson: Examining the anatomy\, physiology\, and function of claustrum-cortical neurons
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe claustrum is a small brain region forming dense synaptic connections with most of the cerebral cortex. However\, the function of this region remains a mystery. I will highlight recent work from our group mapping the connectivity of claustrum neurons and determining how these cells control distinct cortical modules to participate in cognitive functions such as memory.
URL:https://www.centreforbrainhealth.ca/events/dr-jesse-jackson/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230414T110000
DTEND;TZID=America/Vancouver:20230414T120000
DTSTAMP:20231124T144003
CREATED:20220620T202725Z
LAST-MODIFIED:20230224T214943Z
UID:9135-1681470000-1681473600@www.centreforbrainhealth.ca
SUMMARY:Dr. Jared Young: Crossing the death valleys of the translational continuum: Coupling domain specificity with clinical sensitivity
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe vast majority of drugs fail when trying to go from animals to humans.  Some fields fail more than others\, with psychiatry being at the pinnacle of a competition no field wants to win.  Understanding behavior has been difficult enough\, delineating what went awry at the genetic and environmental level throughout development\, to give rise to a myriad of disorders characterized by their behavior – is there a haystack big enough for that one needle?  Then developing drugs targeting those mechanisms?  First and foremost it is our job to delineate neural mechanisms underlying normal behavior.  To do that\, we must utilize tasks with domain-task specificity\, wherein we are confident that the cognitive domain measured in animals matches that tested in humans.  We can validate these tasks\, examining their face\, predictive (including pharmacological)\, and neurobiological validities.  For treatment development\, we also need to make sure that it is a domain worth targeting – do patients exhibit deficient performance\, does the task have clinical sensitivity?  I will present data we have generated over the past two decades demonstrating this process\, how translational task-development can work in forward and reverse\, how working with clinicians enabled testing the clinical sensitivity of even some of the simplest tasks in rodents such as exploration\, and effortful motivation.  This work culminates in testing potential treatments that patients guide us toward\, such as cannabis for attenuating risk-taking in people with bipolar disorder.  Thus\, from potential pharmacotherapies\, more targeted treatments can be through this use of domain specificity in testing.
URL:https://www.centreforbrainhealth.ca/events/dr-jared-young/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230331T110000
DTEND;TZID=America/Vancouver:20230331T120000
DTSTAMP:20231124T144003
CREATED:20210722T000000Z
LAST-MODIFIED:20230320T224544Z
UID:3747-1680260400-1680264000@www.centreforbrainhealth.ca
SUMMARY:Dr. Joseph Cheer: Endogenous cannabinoids and the pursuit of reward
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn the early stages of substance abuse\, subjects receive a drug that is highly reinforcing and are thus likely to repeat the actions that led them to obtain it.  This is termed positive reinforcement. However\, in a minority of people who develop an addiction phenotype\, negative reinforcement also causes a behavior to be repeated\, but in this case\, the action causes a bad feeling or situation to go away. The mesolimbic dopamine system\, which is thought to generate a teaching signal\, is involved in the selection of advantageous behavioral repertoires. This brain pathway is under control of endocannabinoid (eCBs)\, ubiquitous signaling molecules that bind to the same receptor targeted by marijuana (CB1) known to strengthen responses leading to the procurement of reward. Here\, we investigate how eCBs modulate dopaminergic encoding of cues predicting either\, appetitive stimuli\, the avoidance of punishment or aversive outcomes. We find that disrupting eCB signaling by treating animals with a CB1 receptor antagonist dose-dependently decreased concentrations of dopamine release in the nucleus accumbens that were time-locked to a warning signal that predicts avoidance of punishment while simultaneously weakening shock avoidance behavior\, effectively shifting the behavioral outcome from avoidance to escape. We further demonstrate\, using directed mutagenesis approaches\, that 2AG release from dopamine neurons in the midbrain is a canonical mechanism responsible for the pursuit of rewards. \nIt has been posited that compromised motivation in HD or “apathy” arises from a deficit in preparing for and initiating goal-directed behavior. Apathy is always the primary deficit in motivation associated with frontal-subcortical diseases such as HD. Indeed\, apathy may be a core feature of HD disease pathology itself. In many cases apathy follows a similar trajectory as motor symptom progression in PD\, although it can become prevalent before phenoconversion. It can be the result of several neurobiologically maladaptive systems\, including affective (flattening of emotional responsiveness)\, behavioral (reduced initiation of spontaneous behavior)\, and executive dysfunction (difficulty planning/executing). Thus\, motivational dysfunction in HD is a deficit primarily in preparation for motivated behavior that can have debilitating co-morbid consequences. \nGaps in knowledge \n\nLoss of striatal cannabinoid type 1 (CB1) receptors is a key pathogenic of several neurodegenerative diseases\, including HD.\nTreatment for metabolic syndrome with the CB1 receptor antagonist Rimonabant was halted by the FDA because of loss of motivation and depressive ideation.\nHD patients tend to smoke marijuana as a way to self-medicate and to prevent feelings of loneliness and helplessness.\nLoss of goal-directed behavior in HD is specific to the incentive value of the reinforcer.\nTreatment with indirect cannabinoid agonists profoundly increases operationally defined indices of motivation in normal animals and reverses apathy via dopaminergic mechanisms in mouse models of HD.\n\nTogether these data suggest that eCBs might modify distinct behavioral responses related to exteroceptive stimuli by modulating conditioned mesolimbic dopamine release events.  These findings suggest that therapies aimed at modifying tissue levels of eCBs may be used to prevent drug seeking driven by negative affective states or improve motivational indices in animal models of HD. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-joseph-cheer/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230324T110000
DTEND;TZID=America/Vancouver:20230324T120000
DTSTAMP:20231124T144003
CREATED:20221201T201738Z
LAST-MODIFIED:20230117T213557Z
UID:10052-1679655600-1679659200@www.centreforbrainhealth.ca
SUMMARY:Dr. Kathleen Morrison: Role for chromatin remodeling in the lifelong consequences of pubertal adversity on the brain and behavior
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nPuberty and ensuing adolescence represent a time when the brain is rapidly developing and is sensitive to environmental stimuli. This lecture will discuss evidence that pubertal adversity puts females at risk for altered stress responding and maternal behavior later in life. Evidence will be presented that pubertal stress leads to an enduring programmatic event in the chromatin landscape in several brain regions\, which may underlie both the lasting transcriptomic and behavioral consequences of pubertal stress.
URL:https://www.centreforbrainhealth.ca/events/dr-kathleen-morrison/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230317T110000
DTEND;TZID=America/Vancouver:20230317T120000
DTSTAMP:20231124T144003
CREATED:20210722T000000Z
LAST-MODIFIED:20230109T182025Z
UID:3748-1679050800-1679054400@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael Drew: Hippocampal mechanisms of fear suppression and relapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nLearned fear often relapses after extinction\, suggesting that extinction training generates a new memory that coexists with the original fear memory. Recent work from our lab has identified the hippocampus as a region where such fear and extinction memories exist and compete for expression. In this talk I will discuss recent work in our lab in which we have used activity-dependent neural tagging in mice to identify\, manipulate\, and characterize the cellular mechanisms of these hippocampal fear and extinction memories. I will discuss (1) where in the hippocampus these memory representations exist\, (2) evidence that fear and extinction memories are coded by molecularly distinct cell ensembles\, and (3) evidence that expression of fear and extinction is mediated by activation unique hippocampal output pathways.
URL:https://www.centreforbrainhealth.ca/events/dr-michael-drew/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230310T110000
DTEND;TZID=America/Vancouver:20230310T120000
DTSTAMP:20231124T144003
CREATED:20220714T200422Z
LAST-MODIFIED:20230308T233026Z
UID:9317-1678446000-1678449600@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Neha Suvindran and Drs. Rebecca Todd & Stan Floresco
DESCRIPTION:Neha Suvindran: “Reimagining Neuro-Bioelectronic Systems: Sustainable\, Stable and Self-healing Fiber Electrodes”\nDrs. Rebecca Todd and Stan Floresco: “Translation Investigation of Neurophysiological Substrates of Active and inhibitory Avoidance in healthy and depressed populations.”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-neha-suvindran-and-rebecca-todd/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230303T110000
DTEND;TZID=America/Vancouver:20230303T120000
DTSTAMP:20231124T144003
CREATED:20220714T200002Z
LAST-MODIFIED:20230302T010113Z
UID:9315-1677841200-1677844800@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Drs. Annie Ciernia and Paul van Donkelaar
DESCRIPTION:Dr. Annie Ciernia: “Mechanisms of Peripheral Lipopolysaccharide Induced Brain Inflammation”\nDr. Paul van Donkelaar: “Characterizing tau pathology in survivors of intimate partner violence-related traumatic brain injury”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-drs-annie-ciernia-and-paul-van-donkelaar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230224T110000
DTEND;TZID=America/Vancouver:20230224T120000
DTSTAMP:20231124T144003
CREATED:20220708T172733Z
LAST-MODIFIED:20230210T001332Z
UID:9281-1677236400-1677240000@www.centreforbrainhealth.ca
SUMMARY:Dr. Joni Wallis: Neuronal mechanisms of value-based decision-making: a brain-machine interface approach
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDecision-making is an unobservable cognitive process. This makes it challenging to investigate the underlying neuronal mechanisms. This lecture will discuss how techniques borrowed from the brain-machine interface field\, such as decoding population activity and closed-loop control\, can be used to understand how cognitive processes such as decision-making are implemented at the neuronal level. This approach could also lead to the development of novel devices for the treatment of neuropsychiatric disorders that involve impaired decision-making.
URL:https://www.centreforbrainhealth.ca/events/dr-joni-wallis/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230203T110000
DTEND;TZID=America/Vancouver:20230203T120000
DTSTAMP:20231124T144003
CREATED:20220704T174420Z
LAST-MODIFIED:20230105T182151Z
UID:9207-1675422000-1675425600@www.centreforbrainhealth.ca
SUMMARY:Dr. Anastassia Voronova: (Re)generating oligodendrocytes in the developing and degenerating brain: a neural stem cell perspective
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nObjectives: \n1) Neural stem cells build and regenerate the brain in part by forming oligodendrocytes\, the myelinating cells of the central nervous system \n2) Endogenous neural stem cells can be engaged in mouse models of neurodegenerative disorders for brain remyelination \n3) Neurodegenerative disorders may have a neurodevelopmental origin\, and neurodevelopmental disorders may have a neurodegenerative component.
URL:https://www.centreforbrainhealth.ca/events/dr-anatassia-voronova/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230120T110000
DTEND;TZID=America/Vancouver:20230120T120000
DTSTAMP:20231124T144003
CREATED:20220519T204558Z
LAST-MODIFIED:20230119T223200Z
UID:9022-1674212400-1674216000@www.centreforbrainhealth.ca
SUMMARY:Dr. Yuki Oka: Regulation of fluid homeostasis through gut-brain signaling
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Oka will discuss how innate instinct to consume water and salt is regulated through body-brain interactions.
URL:https://www.centreforbrainhealth.ca/events/dr-yuki-oka/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230113T110000
DTEND;TZID=America/Vancouver:20230113T120000
DTSTAMP:20231124T144003
CREATED:20220519T204455Z
LAST-MODIFIED:20230109T182247Z
UID:9020-1673607600-1673611200@www.centreforbrainhealth.ca
SUMMARY:Dr. Susan Gauthier: Imaging a new treatment target in Multiple Sclerosis: Chronic Active Lesions
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nInnate immunity plays a pivotal role in the pathophysiology of multiple sclerosis (MS) and important cell types involved in this process are CNS resident monocytes (microglia) and blood-derived macrophages. Chronic CNS inflammation in the MS lesion is maintained\, in part\, with iron-laden pro-inflammatory microglia/macrophages (m/M) at the rim of chronic active MS lesions. These lesions are felt to contribute to a more aggressive phenotype of the disease; thus\, represents a novel treatment target to reduce disease progression in MS. Identification of the subset of these lesions with a paramagnetic rim has been the focus of several in vivo studies evaluating the cross-sectional association of these lesions with disability\, however further work is required to advance the development of this potential treatment biomarker. Utilizing quantitative susceptibility mapping (QSM) to measure chronic active lesions\, our group has focused on generating tools to identify and quantify lesion-based chronic innate immune activity.  In this talk\, I will review imaging approaches to identify chronic lesion-based inflammation and the impact of chronic active lesions on the disease course. I will further propose a novel application of QSM to quantify the inflammatory trajectory within chronic active lesions and provide a new treatment target in MS for current or novel immune modulators
URL:https://www.centreforbrainhealth.ca/events/dr-susan-gauthier/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221209T110000
DTEND;TZID=America/Vancouver:20221209T120000
DTSTAMP:20231124T144003
CREATED:20220927T203729Z
LAST-MODIFIED:20221122T195911Z
UID:9656-1670583600-1670587200@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael Kobor: Epigenetics and the Human Life Course
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nDr. Michael Kobor is a Professor in the Department of Medical Genetics at the University of British Columbia (UBC) and The Edwin S.H. Leong UBC Chair in Healthy Aging—a UBC President’s Excellence Chair. He began his academic studies in his native Germany\, before coming to Canada to complete his PhD in Medical Genetics under Dr. Jack Greenblatt at the University of Toronto. He then completed postdoctoral training as a Human Frontier Science Program Fellow with Dr. Jasper Rine at the University of California\, Berkeley. Dr. Kobor has received many distinctions\, including a Tier 1 Canada Research Chair in Social Epigenetics\, the Sunny Hill BC Leadership Chair in Child Development\, and an appointment as Fellow of the Canadian Institute for Advanced Research (CIFAR) Child and Brain Development Program. A champion for translational research\, he previously served as the Director for the “Healthy Starts” Theme at BC Children’s Hospital Research Institute. He also leads the UBC Social Exposome Research Cluster\, an interdisciplinary effort spanning 8 Faculties that investigates the health effects of social and environmental factors and influences policies and interventions to reduce health disparities. Dr. Kobor is internationally recognized as a world-leader in the field of epigenetics and leads a program of research focused on illuminating the mechanisms by which environmental exposures and life experiences can “get under the skin” to persistently affect health and behaviour across the lifespan. \nObjectives \n\nTo learn about the importance and complexity of epigenetics across the human life course\nTo understand the various ways by which the epigenome can inform on human health and disease\nTo explore opportunities for collaborative research in human epigenetics and learn about the new Edwin S.H. Leong Healthy Aging Program at UBC
URL:https://www.centreforbrainhealth.ca/events/dr-michael-kobor/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221125T110000
DTEND;TZID=America/Vancouver:20221125T120000
DTSTAMP:20231124T144003
CREATED:20220706T193133Z
LAST-MODIFIED:20221025T234333Z
UID:9239-1669374000-1669377600@www.centreforbrainhealth.ca
SUMMARY:Dr. Fabian Voigt: Expanding the optical bag of tricks for neuroscience 
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nSeeing is believing and thus\, optical imaging techniques are extremely useful to study brain structure and function. I will present two projects aimed at providing the neuroscience community with better imaging instrumentation. In the first part\, I will introduce the mesoSPIM ( http://mesospim.org/ )\, an open-source light-sheet microscope that is optimized for fast imaging of large cleared tissue samples at 5-7 µm isotropic resolution. Since 2015\, the mesoSPIM evolved from a crude prototype into a highly capable instrument and we built a global community around it. Currently\, we are developing a benchtop mesoSPIM that is more compact and cost-efficient. In the second part\, I will talk about a recent project that takes inspiration from scallops and astronomy to build novel multi-immersion microscope objectives that are well suited for imaging cleared samples. These objectives combine long working distances (>1 cm)\, large FOVs (>1 mm)\, high numerical aperture (currently up to 1.08) with diffraction-limited resolution in any homogeneous medium ranging from air to the typical high-index immersion liquids used for imaging cleared tissue. They are especially well suited to augment low-to-mid resolution mesoSPIM overviews with high-resolution datasets.
URL:https://www.centreforbrainhealth.ca/events/dr-fabian-voigt/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221118T110000
DTEND;TZID=America/Vancouver:20221118T120000
DTSTAMP:20231124T144003
CREATED:20220706T193905Z
LAST-MODIFIED:20221027T193214Z
UID:9113-1668769200-1668772800@www.centreforbrainhealth.ca
SUMMARY:Drs. George Augustine\, Lim Kah Leong and Nagaendran Kandiah
DESCRIPTION:Professor George Augustine –  Nanyang Technological University\, Singapore\nTalk Title: “Synapses and synaptic circuits in health and disease”\nProfessor Lim Kah Leong – Nanyang Technological University\, Singapore\nTalk Title: “Neuroprotective and neurorestorative strategies for Parkinson’s disease”\nProfessor Nagaendran Kandiah –  Nanyang Technological University\, Singapore\nTalk Title: “Fluid biomarker and neuroimaging profile of mild cognitive impairment in Southeast Asians”\n\nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/nanyang-technological-university/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221104T110000
DTEND;TZID=America/Vancouver:20221104T120000
DTSTAMP:20231124T144003
CREATED:20220706T174256Z
LAST-MODIFIED:20221025T234203Z
UID:9233-1667559600-1667563200@www.centreforbrainhealth.ca
SUMMARY:Dr. Ryan McLaughlin: Lost in Translation: Leveraging Preclinical Models to Interrogate Effects of Developmental Cannabis Exposure
DESCRIPTION:Maternal cannabis use is a growing public health concern\, yet the long-term effects of prenatal cannabis exposure remain elusive. Our understanding of how prenatal cannabis exposure affects the brain and behavior is critically informed by preclinical animal models that capture core components of human cannabis use. To this end\, our laboratory and others have recently developed more translational models of cannabis use that have potential to provide unprecedented insight into the protracted effects of cannabis exposure during sensitive developmental stages.  In this presentation\, I will describe recent data from our laboratory using a novel model of cannabis vapor self-administration in pregnant rat dams to investigate the long-term effects of maternal cannabis use on emotional reactivity\, cognitive flexibility\, and cannabis-seeking behavior. Additionally\, I will present emerging data from our laboratory revealing altered excitatory inputs onto corticostriatal projection neurons in cannabis-exposed adult offspring\, which could represent a mechanism by which prenatal cannabis exposure impacts reward-relevant behavior. Altogether\, our data support the use of the cannabis vapor self-administration approach to investigate long-term effects of maternal cannabis use in developing offspring. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\n 
URL:https://www.centreforbrainhealth.ca/events/dr-ryan-mclaughlin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221028T110000
DTEND;TZID=America/Vancouver:20221028T120000
DTSTAMP:20231124T144003
CREATED:20220604T014447Z
LAST-MODIFIED:20221025T234115Z
UID:9070-1666954800-1666958400@www.centreforbrainhealth.ca
SUMMARY:Dr. Mihaela Iordanova: Neurobiology of secondary fear triggers
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nThe study of how the brain regulates learned fear has been fundamental to understanding brain function and has served as a pre-clinical animal model for fear- and anxiety-related disorders in humans. The current model has exclusively focused on primary triggers for fear\, that is\, fear acquired through direct pairings between a cue and a fear-eliciting event. However\, fear is also elicited by secondary triggers\, that is\, cues that were never directly paired with the aversive event. These secondary triggers gain fear-eliciting properties by virtue of their association with primary triggers. The talk will present data showing how fear memories propagate across the memory network allowing for the development of secondary fear triggers\, how those memories are regulated by fear to the primary triggers at the behavioural and neural level\, as well as how they are supported by circuits in the brain.
URL:https://www.centreforbrainhealth.ca/events/dr-mihaela-iordanova/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221021T110000
DTEND;TZID=America/Vancouver:20221021T120000
DTSTAMP:20231124T144003
CREATED:20220604T014344Z
LAST-MODIFIED:20220805T201802Z
UID:9068-1666350000-1666353600@www.centreforbrainhealth.ca
SUMMARY:Dr. Anthony Filiano: Regulating the Brain from Its Borders
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nThe CNS is an immune-privileged organ\, yet we know that peripheral immunity is critical for proper brain function. Here we will discuss cell communications in the meninges that regulate patrolling T cells and how the brain responds to T cell-derived signals.
URL:https://www.centreforbrainhealth.ca/events/dr-anthony-filiano/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221014T110000
DTEND;TZID=America/Vancouver:20221014T120000
DTSTAMP:20231124T144003
CREATED:20220604T014225Z
LAST-MODIFIED:20220805T201827Z
UID:9066-1665745200-1665748800@www.centreforbrainhealth.ca
SUMMARY:Dr. Eric Yttri: Understanding brain-wide circuit dynamics underlying learned and spontaneous behavior with B-SOiD
DESCRIPTION:For decades\, neuroscience has focused almost exclusively on stereotyped\, reductionist\, and over-trained behaviors due to their ease of study. In contrast\, naturalistic behavior provides a rich diversity of movements\, but this feature also largely precludes it from quantification and use. Recent advances in computer vision have enabled automatic tracking of the position of body parts – but position is not behavior. To provide a bridge from positions to behaviors and their kinematics\, we developed B-SOiD (Hsu and Yttri\, Nature Communications). This open-source method discovers natural spatiotemporal patterns in body position data\, then uses the cluster statistics to train a machine learning algorithm to classify behaviors that can generalize across subjects and labs. We will discuss the application of this user-friendly algorithm in flies\, mice\, and humans. Finally\, we will share new data from recordings throughout the cortex and basal ganglia that reveal how these diverse behaviors are encoded by single units and interconnected neural populations. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\n  \n 
URL:https://www.centreforbrainhealth.ca/events/dr-eric-yttri/
LOCATION:British Columbia
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220923T110000
DTEND;TZID=America/Vancouver:20220923T120000
DTSTAMP:20231124T144003
CREATED:20220604T014013Z
LAST-MODIFIED:20220808T163820Z
UID:9064-1663930800-1663934400@www.centreforbrainhealth.ca
SUMMARY:Dr. Eugenii A. (Ilan) Rabiner: Molecular Imaging in CNS drug development
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nOver the past 25 years the costs of drug development have been rising steeply\, with later phases being particularly resource intensive. Molecular imaging (primarily PET) has become an indispensable tool in early phase drug development\, especially for compounds focused on CNS targets\, PET studies conducted at an appropriate enable the refinement of the dose range to be explored in later phase studies\, leading to time and resource savings\, as well as providing early demonstration of compounds that are going to fail\, leading to early termination and the reallocation of considerable resources. This talk will discuss the application of PET and MR imaging in early phase drug development\, within the framework of the “three pillars” of drug development and provide examples of such studies.
URL:https://www.centreforbrainhealth.ca/events/dr-eugenii-a-ilan-rabiner/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220916T110000
DTEND;TZID=America/Vancouver:20220916T120000
DTSTAMP:20231124T144003
CREATED:20220604T013819Z
LAST-MODIFIED:20220815T171642Z
UID:9062-1663326000-1663329600@www.centreforbrainhealth.ca
SUMMARY:Dr. Kim Green: Exploring  microglia  function  in  the healthy and Alzheimer’s disease brain
DESCRIPTION:Microglia are the primary immune cell of the brain\, but have roles outside of immunity as well as being implicated in the pathogenesis of many CNS disorders. Here I will show how we can use CSF1R inhibitors to control the microglial population in vivo\, and elucidate their functions in both the homeostatic and disease brains. I will focus on the involvement of microglia in Alzheimer’s disease\, and also detail several new genetic models to understand the disease progression. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-kim-green/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220909T110000
DTEND;TZID=America/Vancouver:20220909T120000
DTSTAMP:20231124T144003
CREATED:20220604T013640Z
LAST-MODIFIED:20220805T201639Z
UID:9060-1662721200-1662724800@www.centreforbrainhealth.ca
SUMMARY:Dr. Anke Henning: Metabolic MRI at ultra-high fields – from systems architecture to application
DESCRIPTION:Metabolic MRI allows observing energy metabolism\, neurotransmission\, second messaging\, endocrine signaling\, antioxidants\, protein metabolism and dynamic membrane processes in the human brain. Related quantitative metabolic imaging biomarkers are beneficial for differential diagnostics\, monitoring of treatment response and patient stratification in various neurological and psychiatric disorders and yield complementary information to structural and functional imaging. To visualize related metabolic processes my research group develops methodology for highly spatially and temporally resolved metabolic imaging exploiting magnetic resonance spectroscopy (MRS)\, chemical exchange saturation transfer (CEST) and non-proton spectroscopic imaging (31P\, 13C\, 2H) at 3T\, 7T and 9.4T with application in the human brain\, spinal cord and myocardium. These methods allows for non-invasive and non-ionizing determination of tissue concentrations and metabolic turn-over rates of more than 20 metabolites and ions and specifically benefits from ultrahigh field strength with regard to spectral resolution and signal-to-noise ratio. \nHowever\, specific physical and technical challenges have to be overcome to fully exploit the advantages of ultrahigh field MR at 7T and 9.4T for human MRI and MRS. Hence my laboratory invests into the development of enabling technology for ultrahigh field MRI including scan hardware such as radiofrequency coils and static magnetic field shimming\, numerical optimization of these setups and is able to perform respective safety assessment to allow for application in humans. The lab also develops scan software including MRI sequences and is able to design tailored radiofrequency pulse including such dedicated to parallel transmission systems. Specifically for metabolic MRI we also develop tailored data analysis methods such as image reconstruction\, post-processing and quantification pipelines and recently started to explore machine-learning based approaches. \nThis presentation gives an overview over our recent research activities. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-anke-henning/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220513T110000
DTEND;TZID=America/Vancouver:20220513T120000
DTSTAMP:20231124T144003
CREATED:20220412T221303Z
LAST-MODIFIED:20220511T232211Z
UID:8817-1652439600-1652443200@www.centreforbrainhealth.ca
SUMMARY:Dr. Takao Hensch: Balancing Brain Plasticity/Stability
DESCRIPTION:Brain function is largely shaped by experience in early life\, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods\, identifying both “triggers” and “brakes” on plasticity. Strikingly\, the maturation of particular inhibitory circuits is pivotal for the onset timing of these windows. Manipulations of their emergence can either accelerate or delay developmental trajectories regardless of chronological age. Notably\, many neurodevelopmental disorders are linked to alterations in excitatory-inhibitory balance\, suggesting shifted critical period timing as part of their etiology. Closure of critical periods in turn reflects an active process\, rather than a purely passive loss of plasticity factors. Lifting these brakes allows the reopening of plastic windows later in life\, but may also underlie instability in disease states. Thus\, understanding how brain plasticity and stability are balanced throughout life offers new insight into mental illness and novel therapeutic strategies for recovery of function in adulthood. \n\nZoom option if unable to attend in person\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nTo attend the trainee lunch following the seminar or to schedule a meeting with Dr. Hensch\, please email Kim at kschmidt@mail.ubc.ca
URL:https://www.centreforbrainhealth.ca/events/dr-takao-hensch/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/04/Takao-Hensch-presentation-May-13.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220506T110000
DTEND;TZID=America/Vancouver:20220506T120000
DTSTAMP:20231124T144003
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185558Z
UID:3749-1651834800-1651838400@www.centreforbrainhealth.ca
SUMMARY:Dr. Elizabeth Heller: Epigenetic regulation of reward pathophysiology
DESCRIPTION:The Heller Lab research program is focused on discovering molecular mechanisms by which epigenetic reprogramming contributes to neuropsychiatric disease. To this end\, Dr. Heller pioneered the use of targeted epigenetic editing in brain\, to elucidate the precise causal role of histone posttranslational modifications on gene expression and alternative splicing in specific neuronal subpopulations. Dr. Heller will share recent studies of epigenetic regulation of gene expression and alternative splicing across cocaine abstinence in mice\, as well as novel approaches to examine histone modifications in specific neuronal subpopulations. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-elizabeth-heller/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220429T110000
DTEND;TZID=America/Vancouver:20220429T120000
DTSTAMP:20231124T144003
CREATED:20210722T000000Z
LAST-MODIFIED:20220315T212653Z
UID:3745-1651230000-1651233600@www.centreforbrainhealth.ca
SUMMARY:Dr. Nelson Spruston: Neurophysiological mechanisms of memory guided behavior
DESCRIPTION:Mammals use a sophisticated\, multi-regional memory system to guide behavior. A major goal of neuroscience is to understand the mechanisms—ranging from molecular to cellular to systems—that make this possible. Spruston will describe recent results from his lab using mouse behavior\, patch-clamp recording\, imaging\, and RNA-seq\, which collectively seek to elucidate how a diverse and complex population of neurons in the hippocampus allow mice to perform sophisticated memory guided behaviors. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-nelson-spruston/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220422T110000
DTEND;TZID=America/Vancouver:20220422T120000
DTSTAMP:20231124T144003
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185511Z
UID:3744-1650625200-1650628800@www.centreforbrainhealth.ca
SUMMARY:Dr. Pascal Kaeser: Mechanisms and Roles for Fast Dopamine Signaling
DESCRIPTION:Dopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I will present data on triggering mechanisms of dopamine release and evaluate its roles in striatal regulation. In the long-term\, our work will allow for a better understanding of the mechanisms and time scales of dopamine coding in health and disease. \n“Live Screening” in Rudy North Lecture Theatre\nZoom details if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-pascal-kaeser/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220408T120000
DTEND;TZID=America/Vancouver:20220408T130000
DTSTAMP:20231124T144003
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185332Z
UID:3743-1649419200-1649422800@www.centreforbrainhealth.ca
SUMMARY:Dr. Shigeki Watanabe: Ultrafast recycling of synaptic vesicles
DESCRIPTION:In 1973 John Heuser and Tom Reese demonstrated that neurotransmitter was released from neurons via the fusion of neurotransmitter-filled vesicles with the cell membrane.  But at the same time\, these experiments launched a controversy that is unresolved today – do vesicles collapse into the membrane and are then recycled slowly on the order of 20 seconds? Or do they retain their existence – and reverse the pore in just 1 second\, as proposed in ‘kiss and run’ endocytosis?  Since then\, molecular pathways for fusion and recycling have been put forward\, but the field remains divided.  We have used channelrhodopsin to stimulate neurons in intact nematodes and in cultured hippocampal neurons.  The specimen is then frozen 15 ms to 20 seconds after the stimulus. To our surprise\, we observed a different form of vesicle recycling that is ultrafast\, in which membrane is endocytosed at lateral edges of active zones between 30-100 ms after stimulation.  The large endocytic vesicles then fuse to form an endosome and are resolved by clathrin into synaptic vesicles. Although rapid\, several molecules coordinately mediate ultrafast endocytosis. I will discuss the findings from the original studies and our current work on molecular mechanisms underlying ultrafast endocytosis. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-shigeki-watanabe/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220401T110000
DTEND;TZID=America/Vancouver:20220401T120000
DTSTAMP:20231124T144003
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185300Z
UID:3742-1648810800-1648814400@www.centreforbrainhealth.ca
SUMMARY:Dr. Bojana Stefanovic: Neurovascular unit dysfunction in a model of TBI
DESCRIPTION:Mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury globally. Although its consequences may be short term\, mTBI often leads to long-term neuropsychiatric and neurological impairments and has been estimated to increase the probability of later life dementia up to six-fold. It is presently not clear what neuropathological changes underlie these deficits. This talk will review our recent studies on the sustained neurogliovascular unit function changes in a murine model of repeated\, mild traumatic brain injury. By leveraging two photon fluorescence microscopy\, intracerebral electrophysiological recordings\, optogenetics\, high field magnetic resonance imaging\, and light sheet fluorescence microscopy\, we reveal pronounced\, lasting\, and diffuse changes in the neuronal and cerebrovascular functional signals in situ\, accompanied by only subtle changes in histopathological readouts and no changes on conventional neuroimaging. Our studies suggest the potential of disinhibitory interventions to ameliorate peri-contusional neuronal and cerebrovascular tone and reactivity. In light of known import of functional hyperemia for healthy brain functioning\, normalization of the neurovascular unit function is likely key for decreasing the susceptibility of the concussed brain to subsequent pathologies. We expect sensitive in situ functional assays to be instrumental for development of such neurovascularly targeted interventions in the clinic. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-bojana-stefanovic/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR