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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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DTSTART:20230312T100000
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DTSTART;TZID=America/Vancouver:20231201T110000
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DTSTAMP:20231124T111237
CREATED:20230404T192402Z
LAST-MODIFIED:20231022T181816Z
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SUMMARY:Dr. Mark Bevan: Dysregulation and rescue of subthalamic nucleus locomotor function in Huntington’s disease mice
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn this seminar I will focus on our recent studies on the role of the subthalamic nucleus in motor control and its dysregulation in movement disorders.  We found that 1) subthalamic locomotor encoding and gait are highly dysregulated in Q175 Huntington’s disease (HD) mice 2) analogous gait deficits could be generated in wild type mice through optogenetic manipulation of subthalamic activity 3) subthalamic locomotor encoding and gait could be rescued in HD mice through suppression of subthalamic mutant huntingtin expression. Together\, these findings argue that subthalamic activity normally optimizes movement\, whereas dysregulated subthalamic activity contributes to gait deficits in HD and is a potential target for therapeutic intervention.
URL:https://www.centreforbrainhealth.ca/events/dr-mark-bevan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
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