BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Djavad Mowafaghian Centre for Brain Health | DMCBH - ECPv6.2.6//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Vancouver
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231201T110000
DTEND;TZID=America/Vancouver:20231201T120000
DTSTAMP:20231124T111133
CREATED:20230404T192402Z
LAST-MODIFIED:20231022T181816Z
UID:10675-1701428400-1701432000@www.centreforbrainhealth.ca
SUMMARY:Dr. Mark Bevan: Dysregulation and rescue of subthalamic nucleus locomotor function in Huntington’s disease mice
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn this seminar I will focus on our recent studies on the role of the subthalamic nucleus in motor control and its dysregulation in movement disorders.  We found that 1) subthalamic locomotor encoding and gait are highly dysregulated in Q175 Huntington’s disease (HD) mice 2) analogous gait deficits could be generated in wild type mice through optogenetic manipulation of subthalamic activity 3) subthalamic locomotor encoding and gait could be rescued in HD mice through suppression of subthalamic mutant huntingtin expression. Together\, these findings argue that subthalamic activity normally optimizes movement\, whereas dysregulated subthalamic activity contributes to gait deficits in HD and is a potential target for therapeutic intervention.
URL:https://www.centreforbrainhealth.ca/events/dr-mark-bevan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231208T110000
DTEND;TZID=America/Vancouver:20231208T120000
DTSTAMP:20231124T111133
CREATED:20230511T164358Z
LAST-MODIFIED:20231124T105827Z
UID:10880-1702033200-1702036800@www.centreforbrainhealth.ca
SUMMARY:Dr. Adrienne Fairhall: Cognitive rule-switching in macaques.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nWhat is the neural basis of abstraction? Working in collaboration with experimental groups who have trained monkeys and humans on a decision task\, we analyze how subjects make use of visual information and feedback to infer a hidden rule\, where the rule switches in an uncued fashion. We fit a suite of behavioral models and learn that while humans are close to optimal Bayesian agents\, monkey behavior is better fit as reinforcement learning\, with a novel additional factor included. We use this behavioral model to elucidate structure in neural activity recorded from 200 sites across the brain\, finding low-dimensional and dynamic representations of stimulus\, feedback and  reward prediction error that support the notion of internal states captured by the behavioral model. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-adrienne-fairhall/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR