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DTSTART;TZID=America/Vancouver:20221021T110000
DTEND;TZID=America/Vancouver:20221021T120000
DTSTAMP:20231124T150850
CREATED:20220604T014344Z
LAST-MODIFIED:20220805T201802Z
UID:9068-1666350000-1666353600@www.centreforbrainhealth.ca
SUMMARY:Dr. Anthony Filiano: Regulating the Brain from Its Borders
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nThe CNS is an immune-privileged organ\, yet we know that peripheral immunity is critical for proper brain function. Here we will discuss cell communications in the meninges that regulate patrolling T cells and how the brain responds to T cell-derived signals.
URL:https://www.centreforbrainhealth.ca/events/dr-anthony-filiano/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221014T110000
DTEND;TZID=America/Vancouver:20221014T120000
DTSTAMP:20231124T150850
CREATED:20220604T014225Z
LAST-MODIFIED:20220805T201827Z
UID:9066-1665745200-1665748800@www.centreforbrainhealth.ca
SUMMARY:Dr. Eric Yttri: Understanding brain-wide circuit dynamics underlying learned and spontaneous behavior with B-SOiD
DESCRIPTION:For decades\, neuroscience has focused almost exclusively on stereotyped\, reductionist\, and over-trained behaviors due to their ease of study. In contrast\, naturalistic behavior provides a rich diversity of movements\, but this feature also largely precludes it from quantification and use. Recent advances in computer vision have enabled automatic tracking of the position of body parts – but position is not behavior. To provide a bridge from positions to behaviors and their kinematics\, we developed B-SOiD (Hsu and Yttri\, Nature Communications). This open-source method discovers natural spatiotemporal patterns in body position data\, then uses the cluster statistics to train a machine learning algorithm to classify behaviors that can generalize across subjects and labs. We will discuss the application of this user-friendly algorithm in flies\, mice\, and humans. Finally\, we will share new data from recordings throughout the cortex and basal ganglia that reveal how these diverse behaviors are encoded by single units and interconnected neural populations. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\n  \n 
URL:https://www.centreforbrainhealth.ca/events/dr-eric-yttri/
LOCATION:British Columbia
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220923T110000
DTEND;TZID=America/Vancouver:20220923T120000
DTSTAMP:20231124T150850
CREATED:20220604T014013Z
LAST-MODIFIED:20220808T163820Z
UID:9064-1663930800-1663934400@www.centreforbrainhealth.ca
SUMMARY:Dr. Eugenii A. (Ilan) Rabiner: Molecular Imaging in CNS drug development
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nOver the past 25 years the costs of drug development have been rising steeply\, with later phases being particularly resource intensive. Molecular imaging (primarily PET) has become an indispensable tool in early phase drug development\, especially for compounds focused on CNS targets\, PET studies conducted at an appropriate enable the refinement of the dose range to be explored in later phase studies\, leading to time and resource savings\, as well as providing early demonstration of compounds that are going to fail\, leading to early termination and the reallocation of considerable resources. This talk will discuss the application of PET and MR imaging in early phase drug development\, within the framework of the “three pillars” of drug development and provide examples of such studies.
URL:https://www.centreforbrainhealth.ca/events/dr-eugenii-a-ilan-rabiner/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220916T110000
DTEND;TZID=America/Vancouver:20220916T120000
DTSTAMP:20231124T150850
CREATED:20220604T013819Z
LAST-MODIFIED:20220815T171642Z
UID:9062-1663326000-1663329600@www.centreforbrainhealth.ca
SUMMARY:Dr. Kim Green: Exploring  microglia  function  in  the healthy and Alzheimer’s disease brain
DESCRIPTION:Microglia are the primary immune cell of the brain\, but have roles outside of immunity as well as being implicated in the pathogenesis of many CNS disorders. Here I will show how we can use CSF1R inhibitors to control the microglial population in vivo\, and elucidate their functions in both the homeostatic and disease brains. I will focus on the involvement of microglia in Alzheimer’s disease\, and also detail several new genetic models to understand the disease progression. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-kim-green/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220909T110000
DTEND;TZID=America/Vancouver:20220909T120000
DTSTAMP:20231124T150850
CREATED:20220604T013640Z
LAST-MODIFIED:20220805T201639Z
UID:9060-1662721200-1662724800@www.centreforbrainhealth.ca
SUMMARY:Dr. Anke Henning: Metabolic MRI at ultra-high fields – from systems architecture to application
DESCRIPTION:Metabolic MRI allows observing energy metabolism\, neurotransmission\, second messaging\, endocrine signaling\, antioxidants\, protein metabolism and dynamic membrane processes in the human brain. Related quantitative metabolic imaging biomarkers are beneficial for differential diagnostics\, monitoring of treatment response and patient stratification in various neurological and psychiatric disorders and yield complementary information to structural and functional imaging. To visualize related metabolic processes my research group develops methodology for highly spatially and temporally resolved metabolic imaging exploiting magnetic resonance spectroscopy (MRS)\, chemical exchange saturation transfer (CEST) and non-proton spectroscopic imaging (31P\, 13C\, 2H) at 3T\, 7T and 9.4T with application in the human brain\, spinal cord and myocardium. These methods allows for non-invasive and non-ionizing determination of tissue concentrations and metabolic turn-over rates of more than 20 metabolites and ions and specifically benefits from ultrahigh field strength with regard to spectral resolution and signal-to-noise ratio. \nHowever\, specific physical and technical challenges have to be overcome to fully exploit the advantages of ultrahigh field MR at 7T and 9.4T for human MRI and MRS. Hence my laboratory invests into the development of enabling technology for ultrahigh field MRI including scan hardware such as radiofrequency coils and static magnetic field shimming\, numerical optimization of these setups and is able to perform respective safety assessment to allow for application in humans. The lab also develops scan software including MRI sequences and is able to design tailored radiofrequency pulse including such dedicated to parallel transmission systems. Specifically for metabolic MRI we also develop tailored data analysis methods such as image reconstruction\, post-processing and quantification pipelines and recently started to explore machine-learning based approaches. \nThis presentation gives an overview over our recent research activities. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-anke-henning/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220513T110000
DTEND;TZID=America/Vancouver:20220513T120000
DTSTAMP:20231124T150850
CREATED:20220412T221303Z
LAST-MODIFIED:20220511T232211Z
UID:8817-1652439600-1652443200@www.centreforbrainhealth.ca
SUMMARY:Dr. Takao Hensch: Balancing Brain Plasticity/Stability
DESCRIPTION:Brain function is largely shaped by experience in early life\, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods\, identifying both “triggers” and “brakes” on plasticity. Strikingly\, the maturation of particular inhibitory circuits is pivotal for the onset timing of these windows. Manipulations of their emergence can either accelerate or delay developmental trajectories regardless of chronological age. Notably\, many neurodevelopmental disorders are linked to alterations in excitatory-inhibitory balance\, suggesting shifted critical period timing as part of their etiology. Closure of critical periods in turn reflects an active process\, rather than a purely passive loss of plasticity factors. Lifting these brakes allows the reopening of plastic windows later in life\, but may also underlie instability in disease states. Thus\, understanding how brain plasticity and stability are balanced throughout life offers new insight into mental illness and novel therapeutic strategies for recovery of function in adulthood. \n\nZoom option if unable to attend in person\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nTo attend the trainee lunch following the seminar or to schedule a meeting with Dr. Hensch\, please email Kim at kschmidt@mail.ubc.ca
URL:https://www.centreforbrainhealth.ca/events/dr-takao-hensch/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/04/Takao-Hensch-presentation-May-13.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220506T110000
DTEND;TZID=America/Vancouver:20220506T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185558Z
UID:3749-1651834800-1651838400@www.centreforbrainhealth.ca
SUMMARY:Dr. Elizabeth Heller: Epigenetic regulation of reward pathophysiology
DESCRIPTION:The Heller Lab research program is focused on discovering molecular mechanisms by which epigenetic reprogramming contributes to neuropsychiatric disease. To this end\, Dr. Heller pioneered the use of targeted epigenetic editing in brain\, to elucidate the precise causal role of histone posttranslational modifications on gene expression and alternative splicing in specific neuronal subpopulations. Dr. Heller will share recent studies of epigenetic regulation of gene expression and alternative splicing across cocaine abstinence in mice\, as well as novel approaches to examine histone modifications in specific neuronal subpopulations. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-elizabeth-heller/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220429T110000
DTEND;TZID=America/Vancouver:20220429T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220315T212653Z
UID:3745-1651230000-1651233600@www.centreforbrainhealth.ca
SUMMARY:Dr. Nelson Spruston: Neurophysiological mechanisms of memory guided behavior
DESCRIPTION:Mammals use a sophisticated\, multi-regional memory system to guide behavior. A major goal of neuroscience is to understand the mechanisms—ranging from molecular to cellular to systems—that make this possible. Spruston will describe recent results from his lab using mouse behavior\, patch-clamp recording\, imaging\, and RNA-seq\, which collectively seek to elucidate how a diverse and complex population of neurons in the hippocampus allow mice to perform sophisticated memory guided behaviors. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-nelson-spruston/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220422T110000
DTEND;TZID=America/Vancouver:20220422T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185511Z
UID:3744-1650625200-1650628800@www.centreforbrainhealth.ca
SUMMARY:Dr. Pascal Kaeser: Mechanisms and Roles for Fast Dopamine Signaling
DESCRIPTION:Dopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I will present data on triggering mechanisms of dopamine release and evaluate its roles in striatal regulation. In the long-term\, our work will allow for a better understanding of the mechanisms and time scales of dopamine coding in health and disease. \n“Live Screening” in Rudy North Lecture Theatre\nZoom details if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-pascal-kaeser/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220408T120000
DTEND;TZID=America/Vancouver:20220408T130000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185332Z
UID:3743-1649419200-1649422800@www.centreforbrainhealth.ca
SUMMARY:Dr. Shigeki Watanabe: Ultrafast recycling of synaptic vesicles
DESCRIPTION:In 1973 John Heuser and Tom Reese demonstrated that neurotransmitter was released from neurons via the fusion of neurotransmitter-filled vesicles with the cell membrane.  But at the same time\, these experiments launched a controversy that is unresolved today – do vesicles collapse into the membrane and are then recycled slowly on the order of 20 seconds? Or do they retain their existence – and reverse the pore in just 1 second\, as proposed in ‘kiss and run’ endocytosis?  Since then\, molecular pathways for fusion and recycling have been put forward\, but the field remains divided.  We have used channelrhodopsin to stimulate neurons in intact nematodes and in cultured hippocampal neurons.  The specimen is then frozen 15 ms to 20 seconds after the stimulus. To our surprise\, we observed a different form of vesicle recycling that is ultrafast\, in which membrane is endocytosed at lateral edges of active zones between 30-100 ms after stimulation.  The large endocytic vesicles then fuse to form an endosome and are resolved by clathrin into synaptic vesicles. Although rapid\, several molecules coordinately mediate ultrafast endocytosis. I will discuss the findings from the original studies and our current work on molecular mechanisms underlying ultrafast endocytosis. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-shigeki-watanabe/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220401T110000
DTEND;TZID=America/Vancouver:20220401T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185300Z
UID:3742-1648810800-1648814400@www.centreforbrainhealth.ca
SUMMARY:Dr. Bojana Stefanovic: Neurovascular unit dysfunction in a model of TBI
DESCRIPTION:Mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury globally. Although its consequences may be short term\, mTBI often leads to long-term neuropsychiatric and neurological impairments and has been estimated to increase the probability of later life dementia up to six-fold. It is presently not clear what neuropathological changes underlie these deficits. This talk will review our recent studies on the sustained neurogliovascular unit function changes in a murine model of repeated\, mild traumatic brain injury. By leveraging two photon fluorescence microscopy\, intracerebral electrophysiological recordings\, optogenetics\, high field magnetic resonance imaging\, and light sheet fluorescence microscopy\, we reveal pronounced\, lasting\, and diffuse changes in the neuronal and cerebrovascular functional signals in situ\, accompanied by only subtle changes in histopathological readouts and no changes on conventional neuroimaging. Our studies suggest the potential of disinhibitory interventions to ameliorate peri-contusional neuronal and cerebrovascular tone and reactivity. In light of known import of functional hyperemia for healthy brain functioning\, normalization of the neurovascular unit function is likely key for decreasing the susceptibility of the concussed brain to subsequent pathologies. We expect sensitive in situ functional assays to be instrumental for development of such neurovascularly targeted interventions in the clinic. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-bojana-stefanovic/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220325T110000
DTEND;TZID=America/Vancouver:20220325T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220304T235814Z
UID:3741-1648206000-1648209600@www.centreforbrainhealth.ca
SUMMARY:Dr. Edward F. Chang: Towards a Speech Neuroprosthetic
DESCRIPTION:Speaking is a unique and defining human behavior.  Over the past decade\, we have focused on deciphering the basic neural code that underlies our ability to speak fluently. \nDuring speech production\, vocal tract movement gestures for all speech sounds are encoded by highly specialized neural activity\, organized as a map\, in the human speech motor cortex.   A major effort is now underway to translate these findings towards building an articulatory-based speech neuroprosthetic device for people who cannot communicate. \n\n\n\nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-edward-f-chang/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220318T110000
DTEND;TZID=America/Vancouver:20220318T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220304T235750Z
UID:3740-1647601200-1647604800@www.centreforbrainhealth.ca
SUMMARY:Dr. Kate Wassum: Amygdala circuitry in reward learning and decision making
DESCRIPTION:To make adaptive decisions we must cast ourselves into the future and consider the outcomes of our potential choices. This prospective consideration is informed by our memories. I will discuss our lab’s recent work investigating the neural circuits responsible for encoding\, updating\, and retrieving reward memories for use in the considerations underlying decision making. We have taken a multifaceted approach to these investigations\, combining recording\, modern circuit dissection\, and behavioral tools. Our results are generally indicating that the basolateral amygdala\, midbrain\, and orbitofrontal cortex work in a circuit to participate in these functions. The cognitive symptoms underlying many psychiatric disorders result from a failure to appropriately learn about and/or anticipate potential future events\, making these basic science data relevant to the understanding and potential treatment of mental illness. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-kate-wassum/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220311T110000
DTEND;TZID=America/Vancouver:20220311T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220301T230646Z
UID:3739-1646996400-1647000000@www.centreforbrainhealth.ca
SUMMARY:Dr. Rutsuko Ito: Ventral hippocampal circuits and the arbitration of approach-avoidance conflict
DESCRIPTION:Approach-avoidance (AA) conflict resolution is a form of decision making that is fundamentally important for survival and requires the effective evaluation of affective stimuli or events with mixed outcomes (positive and negative). Despite the prevailing view of hippocampal involvement in learning and memory processes\, the hippocampus is also thought to be involved in the resolution of AA conflict by exaggerating the value of negative outcomes and increasing the tendency to avoid. Furthermore\, work from my laboratory has implicated the ventral\, but not the dorsal hippocampus\, in mediating affective processes involving learned AA conflict. In this talk\, I will be presenting a set of studies providing evidence of ventral hippocampal (vHPC) mediation of AA decision making when animals are exposed to affectively bivalent (conflicting) cues. I will also present chemogenetic evidence that the control over conflict-elicited AA  behaviours is subfield\, and pathway-specific\, with the investigation extending to the wider extrinsic connectivity of the vHPC with the lateral septum and ventral striatum. \nRudy North Lecture Theatre “Live” Screening\nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-rutsuko-ito/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220218T110000
DTEND;TZID=America/Vancouver:20220218T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220301T222335Z
UID:3737-1645182000-1645185600@www.centreforbrainhealth.ca
SUMMARY:Dr. Jorn Diedrichsen: Exploring the role of the human cerebellum across functional domains
DESCRIPTION:The cerebellum has evolved to support basic sensory-motor functions. In the human brain\, the cerebellar circuitry has dramatically expanded and contributes to virtually every cognitive function\, including working memory\, language\, and social cognition. Given its uniform cytoarchitecture\, it has long been hypothesized that the cerebellar circuit performs a common computation across all these functional domains. But what is this elusive transform? To ultimately answer this question we require a better understanding of the functional diversity of the cerebellum\, it’s connectivity to the neocortex\, and the relationship between cortical and cerebellar processes in each functional domain. I will present results from a number functional neuroimaging studies to characterize cerebellar function across cognitive domains to start to address these questions in a systematic fashion. \nRudy North Lecture Theatre “Live” Screening\nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-jorn-diedrichsen/
LOCATION:British Columbia
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220211T110000
DTEND;TZID=America/Vancouver:20220211T120000
DTSTAMP:20231124T150850
CREATED:20211016T053047Z
LAST-MODIFIED:20220211T005633Z
UID:7205-1644577200-1644580800@www.centreforbrainhealth.ca
SUMMARY:Dr. Cheryl Wellington: Fluid biomarkers in neurology: Clinical and translational studies
DESCRIPTION:Diseases of the brain are among the most challenging disorders to diagnose and treat. Unlike cancer\, where human tissue biopsy specimens are routinely collected\, brain disorders lack routine access to specimens that are essential to make progress in understanding pathophysiology and developing effective treatments. Currently\, most brain diseases are studied in living patients using neuroimaging or invasive cerebrospinal fluid (CSF) collection. New technologies now allow brain-derived substances to be measured in blood\, which is revolutionizing the field of neurology. The Wellington lab is currently collaborating with several local neurologists to develop and validate blood biomarkers for several acute and chronic neurological conditions. Highlights of our studies in Alzheimer’s Disease\, spinal cord injury and hypoxic ischemic brain injury will be presented. We are also present our program to develop and validate parallel assays that work in rodents to better understand the translational relevance of studies in animal models. \n\nZoom option if unable to attend in person\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-cheryl-wellington/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220204T110000
DTEND;TZID=America/Vancouver:20220204T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220211T005611Z
UID:3738-1643972400-1643976000@www.centreforbrainhealth.ca
SUMMARY:Dr. John Kramer: Translational Research in Acute Spinal Cord Injury
DESCRIPTION:This event will be held virtually: \nZoom link
URL:https://www.centreforbrainhealth.ca/events/dr-john-kramer/
LOCATION:Online
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211217T110000
DTEND;TZID=America/Vancouver:20211217T120000
DTSTAMP:20231124T150850
CREATED:20211016T052429Z
LAST-MODIFIED:20211221T202501Z
UID:7201-1639738800-1639742400@www.centreforbrainhealth.ca
SUMMARY:Spontaneous activity\, memory replay\, and the default mode network
DESCRIPTION:Spontaneous activity accounts for most of what the brain does and is likely to be key for information processing in the brain\, but its function is still quite mysterious. Two key spontaneous activity processes are the Default Mode Network (DMN)\, a set of areas that are most markedly connected and active during behavioural idleness\, and memory replay\, the spontaneous reactivation of neural patterns occurring during experience. In the Mohajerani lab\, we test the hypothesis that the DMN plays a key role in memory replay processes. This theory\, if confirmed\, would bring important conceptual advances: to memory studies\, as it would provide a mechanism supporting the formation and consolidation of complex memory representations. I will explore this theory by our ongoing studies of neural activity over the whole mouse cortex in animals running memory tasks. \nZoom option if unable to attend in person: \n\nZoom link here (Click on “Join a meeting”)\nMeeting ID: 95496 072083\nPasscode: 072083
URL:https://www.centreforbrainhealth.ca/events/dr-majid-mohajerani/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211210T110000
DTEND;TZID=America/Vancouver:20211210T120000
DTSTAMP:20231124T150850
CREATED:20211019T222822Z
LAST-MODIFIED:20211221T202222Z
UID:7212-1639134000-1639137600@www.centreforbrainhealth.ca
SUMMARY:Unraveling microglial heterogeneity and stress responses in the embryonic hypothalamus
DESCRIPTION:Zoom option if unable to attend in person: \n\nZoom link here (Click on “Join a meeting”)\nMeeting ID: 95496 072083\nPasscode: 072083
URL:https://www.centreforbrainhealth.ca/events/dr-jessica-rosin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211203T110000
DTEND;TZID=America/Vancouver:20211203T120000
DTSTAMP:20231124T150850
CREATED:20211016T052702Z
LAST-MODIFIED:20211221T202047Z
UID:7202-1638529200-1638532800@www.centreforbrainhealth.ca
SUMMARY:The effects of maternal immune activation on early development in an outbred strain of mice
DESCRIPTION:Our lab is interested in the neural bases for social function\, and we use mouse models for diseases that have social deficits at their core. This talk will present our recent work looking at postnatal development\, juvenile behaviours and autophagy in a mouse model of perinatal infection. \nRudy North Lecture Theatre “Live” Screening\nZoom option if unable to attend in person: \n\nZoom link here (Click on “Join a meeting”)\nMeeting ID: 95496 072083\nPasscode: 072083
URL:https://www.centreforbrainhealth.ca/events/dr-tamara-franklin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211119T110000
DTEND;TZID=America/Vancouver:20211119T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20211117T002332Z
UID:3734-1637319600-1637323200@www.centreforbrainhealth.ca
SUMMARY:Reporting Options for Sexualized Violence
DESCRIPTION:SVPRO is back for a second session! This session will focus on the different options that are available for reporting when sexualized violence has occurred. Not everyone wants to report after being impacted by sexualized violence\, and that’s completely okay. When folks do want to report\, it’s important that they know the full range of options and considerations. Join us to learn about UBC systems\, police reporting\, and human rights reporting systems\, when each may apply\, and how SVPRO supports people navigating these processes. \nZoom option if unable to attend in person: \n\nZoom link here (Click on “Join a meeting”)\nMeeting ID: 95496 072083\nPasscode: 072083
URL:https://www.centreforbrainhealth.ca/events/reporting-options-for-sexualized-violence/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211105T110000
DTEND;TZID=America/Vancouver:20211105T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20220301T222553Z
UID:3733-1636110000-1636113600@www.centreforbrainhealth.ca
SUMMARY:Development of a whole-brain memory trace pipeline for activity-dependent tagging murine lines
DESCRIPTION:We previously created a mouse model to permanently label neurons activated during learning\, the ArcCreERT2 mice (Denny et al.\, 2014\, Neuron). In our first publication\, we extensively characterized the ArcCreERT2 mice and manipulated various parameters to correlate behavioral expression with memory tagging. Using contextual fear conditioning (CFC)\, we showed that mice re-exposed to a fearful context freeze more and have a greater percentage of reactivated cells in the dentate gyrus (DG) and in CA3 than mice exposed to a novel context. Overall\, we found that context\, time\, adult hippocampal neurogenesis\, and stress impact cognition and mood\, and these alterations are paralleled by changes in memory trace activation in the hippocampus. In our more recent studies\, we have investigated how disease states and pharmacological manipulations impact memory traces (Perusini et al.\, 2017; Mastrodonato et al.\, 2018; Lacagnina et al.\, 2019; Leal Santos et al.\, 2021). \nOur ongoing/planned projects are to identify: 1) how individual memories are stored throughout the entire brain using a novel whole-brain imaging pipeline we have recently developed\, 2) how multiple memories are co-stored throughout the brain using a new activity-dependent viral strategy\, and 3) how disease states impact memories\, often resulting in memory loss. \nRudy North Lecture Theatre “Live” Screening\nZoom option if unable to attend in person: \n\nZoom link  here (Click on “Join a meeting”)\nMeeting ID: 95496 072083\nPasscode: 072083
URL:https://www.centreforbrainhealth.ca/events/dr-christine-denny/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211029T110000
DTEND;TZID=America/Vancouver:20211029T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20211106T045737Z
UID:3732-1635505200-1635508800@www.centreforbrainhealth.ca
SUMMARY:Genome-wide approaches to understanding microglia identity and function
DESCRIPTION:Microglia are the macrophages of the brain and participate to its development\, homeostasis\, and defense against pathogens and injuries. Notably\, genetic evidence suggests that they are critically involved in neurodegenerative diseases\, including Alzheimer’s disease. However\, our knowledge of the molecular processes that regulate these cells in the brain remains very rudimentary. \nOver the past few years\, we have concentrated our efforts on trying to understand how gene regulation is achieved in microglia. In particular\, we provided evidence using mouse microglia that signaling factors in the brain provide important regulatory input that enable microglia to acquire their cellular identity. Importantly\, our recent work on human microglia shows that axes of signaling pathways – transcription factors that shape the microglial epigenome and transcriptional characteristics are relatively well conserved between the mouse and human. My talk will provide an overview of these recent findings\, and elaborate on the current approaches that we use to gain a better understanding of the epigenomic mechanisms underlying the different cellular functions of microglia in the brain. \nZoom option if unable to attend in person: \n\nZoom link here (Click on “Join a meeting”)\nMeeting ID: 95496-072083\nPasscode: 072083
URL:https://www.centreforbrainhealth.ca/events/dr-david-gosselin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211022T110000
DTEND;TZID=America/Vancouver:20211022T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20211106T045813Z
UID:3731-1634900400-1634904000@www.centreforbrainhealth.ca
SUMMARY:The olfactory mosaic: How diverse networks shape perception
DESCRIPTION:Our perception of the world begins with stimuli in the environment but is then dramatically shaped by our expectations\, past experience\, and internal state.  Olfactory perception is especially sensitive to these kinds of modulation.  In fact\, input from a diverse network of brain regions conveying multisensory\, homeostatic and experience-dependent information converges on the olfactory system as early as the first stages of odor processing.  This talk will describe our work over the past few years on how activity in non-olfactory regions shapes odor coding and perception.  What you smell is not necessarily what you get. \nRudy North Lecture Theatre “Live” Screening \nZoom option if unable to attend in person: \n\nZoom link here (Click on “Join a meeting”)\nMeeting ID: 95496 072083\nPasscode: 072083
URL:https://www.centreforbrainhealth.ca/events/dr-donald-wilson/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211015T110000
DTEND;TZID=America/Vancouver:20211015T120000
DTSTAMP:20231124T150850
CREATED:20210901T003804Z
LAST-MODIFIED:20211106T050007Z
UID:6448-1634295600-1634299200@www.centreforbrainhealth.ca
SUMMARY:Preventing and Responding to Sexualized Violence
DESCRIPTION:  \n\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 95496 072083\nPasscode: 072083\n\nSVPRO will present UBC’s approach to preventing and responding to sexualized violence\, with a focus on key principles for supporting survivors. The presentation will include what constitutes sexualized violence and prohibited relationships\, standards and considerations for safe and respectful working and learning environments\, and how to respond to a disclosure\, with approaches to help mitigate impacts and reduce harm. This presentation is part one of a two-part series; part 2 (November 19) will focus on reporting options.
URL:https://www.centreforbrainhealth.ca/events/preventing-and-responding-to-sexualized-violence/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211008T110000
DTEND;TZID=America/Vancouver:20211008T120000
DTSTAMP:20231124T150850
CREATED:20211016T045905Z
LAST-MODIFIED:20211106T050044Z
UID:7198-1633690800-1633694400@www.centreforbrainhealth.ca
SUMMARY:Brain-Tech 2021 Hackathon: student teams innovation showcase
DESCRIPTION:This colloquium will present innovation from the top student teams of the Brain-Tech 2021: Idea Generation and Hackathon for Brain Wellness. The Hackathon was hosted by the Dynamic Brain Circuits in Health and Disease Cluster\, the BC Brain Wellness Program\, and the Djavad  Mowafaghian Centre for Brain Health. The Brain-Tech 2021 winners will discuss and demo their work which aims to improve brain wellness.
URL:https://www.centreforbrainhealth.ca/events/brain-tech-2021-hackathon-student-teams-innovation-showcase/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20211001T110000
DTEND;TZID=America/Vancouver:20211001T120000
DTSTAMP:20231124T150850
CREATED:20210831T205406Z
LAST-MODIFIED:20211221T202400Z
UID:6427-1633086000-1633089600@www.centreforbrainhealth.ca
SUMMARY:Sex-specific impact of immune signaling on adolescent neural and social development
DESCRIPTION:  \n\nJoin in person in the auditorium or via the zoom option. The presenter will be remote.\nZoom link here (click on “Join a meeting”)\nMeeting ID:  95496 072083\nPasscode: 072083\n\nIn this presentation\, Dr. Ashley Kopec will discuss published work examining the role of microglia\, the resident immune cells in the brain\, in neural and social development during adolescence in male and female rats. Then\, she will discuss unpublished work aimed at understanding how opioid exposures during adolescence interact with microglia-mediated development to alter future reward-related behaviors. \nThere will be a virtual trainee meeting with Dr. Kopec immediately following her talk (~noon). If you would like to attend the trainee meeting please email annie.ciernia@ubc.ca to sign up. There are limited spots available on a first come first serve basis.
URL:https://www.centreforbrainhealth.ca/events/dr-ashley-kopec/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210917T110000
DTEND;TZID=America/Vancouver:20210917T120000
DTSTAMP:20231124T150850
CREATED:20210722T000000Z
LAST-MODIFIED:20211106T050246Z
UID:3730-1631876400-1631880000@www.centreforbrainhealth.ca
SUMMARY:Canadian Open Neuroscience Platform Scholars Update
DESCRIPTION:Host: Jeff LeDue\nSpeaker: GPN CONP Scholars
URL:https://www.centreforbrainhealth.ca/events/canadian-open-neuroscience-platform-scholars-update/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR