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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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TZID:America/Vancouver
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240202T110000
DTEND;TZID=America/Vancouver:20240202T120000
DTSTAMP:20231124T151245
CREATED:20230508T171612Z
LAST-MODIFIED:20230511T172250Z
UID:10835-1706871600-1706875200@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Drs. Ipek Oruc\, Daniela Palombo and Catharine Winstanley
DESCRIPTION:
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-2/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240126T110000
DTEND;TZID=America/Vancouver:20240126T120000
DTSTAMP:20231124T151245
CREATED:20230508T171528Z
LAST-MODIFIED:20230511T172015Z
UID:10833-1706266800-1706270400@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Dr. Anthony Phillips and Dr. Kamyar Kermatian
DESCRIPTION:
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240119T110000
DTEND;TZID=America/Vancouver:20240119T120000
DTSTAMP:20231124T151245
CREATED:20230328T203831Z
LAST-MODIFIED:20230328T203904Z
UID:10601-1705662000-1705665600@www.centreforbrainhealth.ca
SUMMARY:Dr. Khaled Abdelrahman
DESCRIPTION:
URL:https://www.centreforbrainhealth.ca/events/dr-khaled-abdelrahman/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20240112T110000
DTEND;TZID=America/Vancouver:20240112T120000
DTSTAMP:20231124T151245
CREATED:20230404T193658Z
LAST-MODIFIED:20230404T193719Z
UID:10681-1705057200-1705060800@www.centreforbrainhealth.ca
SUMMARY:Dr. Joshua Berke
DESCRIPTION:
URL:https://www.centreforbrainhealth.ca/events/dr-joshua-berke/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231208T110000
DTEND;TZID=America/Vancouver:20231208T120000
DTSTAMP:20231124T151245
CREATED:20230511T164358Z
LAST-MODIFIED:20231124T105827Z
UID:10880-1702033200-1702036800@www.centreforbrainhealth.ca
SUMMARY:Dr. Adrienne Fairhall: Cognitive rule-switching in macaques.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nWhat is the neural basis of abstraction? Working in collaboration with experimental groups who have trained monkeys and humans on a decision task\, we analyze how subjects make use of visual information and feedback to infer a hidden rule\, where the rule switches in an uncued fashion. We fit a suite of behavioral models and learn that while humans are close to optimal Bayesian agents\, monkey behavior is better fit as reinforcement learning\, with a novel additional factor included. We use this behavioral model to elucidate structure in neural activity recorded from 200 sites across the brain\, finding low-dimensional and dynamic representations of stimulus\, feedback and  reward prediction error that support the notion of internal states captured by the behavioral model. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-adrienne-fairhall/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231201T110000
DTEND;TZID=America/Vancouver:20231201T120000
DTSTAMP:20231124T151245
CREATED:20230404T192402Z
LAST-MODIFIED:20231022T181816Z
UID:10675-1701428400-1701432000@www.centreforbrainhealth.ca
SUMMARY:Dr. Mark Bevan: Dysregulation and rescue of subthalamic nucleus locomotor function in Huntington’s disease mice
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn this seminar I will focus on our recent studies on the role of the subthalamic nucleus in motor control and its dysregulation in movement disorders.  We found that 1) subthalamic locomotor encoding and gait are highly dysregulated in Q175 Huntington’s disease (HD) mice 2) analogous gait deficits could be generated in wild type mice through optogenetic manipulation of subthalamic activity 3) subthalamic locomotor encoding and gait could be rescued in HD mice through suppression of subthalamic mutant huntingtin expression. Together\, these findings argue that subthalamic activity normally optimizes movement\, whereas dysregulated subthalamic activity contributes to gait deficits in HD and is a potential target for therapeutic intervention.
URL:https://www.centreforbrainhealth.ca/events/dr-mark-bevan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231124T110000
DTEND;TZID=America/Vancouver:20231124T120000
DTSTAMP:20231124T151245
CREATED:20230329T174100Z
LAST-MODIFIED:20231003T185618Z
UID:10614-1700823600-1700827200@www.centreforbrainhealth.ca
SUMMARY:Dr. Irene Vavasour: Diving into neuroimaging research with FINS
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe Fipke Integrated Neuroimaging Suite (FINS) hosts state-of-the-art neuroimaging equipment including a 3T Philips MRI scanner and a 3T GE PET/MR scanner. Our translational research includes developing better imaging tools for disorders such as multiple sclerosis\, Parkinson’s\, Alzheimer’s\, stroke\, traumatic brain injury and mental health\, as well as healthy aging. This presentation will discuss many of our novel imaging techniques\, including myelin water imaging\, how and why they are used and what up and coming developments are available.
URL:https://www.centreforbrainhealth.ca/events/dr-irene-vavasour/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231117T110000
DTEND;TZID=America/Vancouver:20231117T120000
DTSTAMP:20231124T151245
CREATED:20230329T173920Z
LAST-MODIFIED:20230829T165650Z
UID:10612-1700218800-1700222400@www.centreforbrainhealth.ca
SUMMARY:Dr. Rosemary Bagot:  At the intersection of threat and reward in nucleus accumbens glutamatergic afferents.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe nucleus accumbens integrates diverse inputs\, balancing threat and reward to orchestrate motivated behaviour. Glutamatergic projections from the ventral hippocampus and medial prefrontal cortex converge in the accumbens medial shell and are implicated in reward processing as well as adaptation to chronic stress. How these pathways integrate aversive or appetitive events to modulate behaviour is not fully understood and largely unstudied in females\, despite known sex-differences in stress-related psychopathologies. I will present new data using pathway-specific in vivo fibre-photometry and chemogenetic silencing to uncover how these projections encode aversive experiences to shape behavioural responding to threat and integrate information about the outcome of actions to shape learning about reward.
URL:https://www.centreforbrainhealth.ca/events/dr-rosemary-bagot/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231103T110000
DTEND;TZID=America/Vancouver:20231103T120000
DTSTAMP:20231124T151245
CREATED:20230424T173144Z
LAST-MODIFIED:20231016T194129Z
UID:10765-1699009200-1699012800@www.centreforbrainhealth.ca
SUMMARY:Dr. Douglas Wylie: Cerebellar Control of Flight in Birds: Easy as 1\, 2\, 3
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe cerebellum contains the majority of neurons in the brain and has been implicated with many aspects of motor control. In birds this includes the control of flight. In this talk\, by synthesizing behavioral\, neurophysiological\, neuroanatomical and paleontological data I will emphasize three points: (i) the expansion of the cerebellum in birds is associated with the evolution of powered flight; (ii) retinal-recipient nuclei that analyze optic flow are critical for controlling flight; and (iii) three different visuomotor areas of the cerebellum are involved in controlling different aspects of flight.
URL:https://www.centreforbrainhealth.ca/events/dr-douglas-wylie/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231020T110000
DTEND;TZID=America/Vancouver:20231020T120000
DTSTAMP:20231124T151245
CREATED:20220604T014558Z
LAST-MODIFIED:20230822T172646Z
UID:9072-1697799600-1697803200@www.centreforbrainhealth.ca
SUMMARY:Dr. Randy McIntosh: Hidden Repertoires in Cognitive Function and Dysfunction
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nA hidden repertoire is a functional configuration in the brain that supports behaviour but is seldom used. As a complex system\, the brain can show a broad range of configurations for the same function. This “many-to-one” property imparts our brain with resilience during normal operations but also in the face of adverse events\, such as damage or disease. I will cover the evidence for these repertoires and cover strategies for investigation\, and the implication for the I will also relate the existence of such repertoires to variations in the qualia of our experience.
URL:https://www.centreforbrainhealth.ca/events/dr-randy-mcintosh/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231013T110000
DTEND;TZID=America/Vancouver:20231013T120000
DTSTAMP:20231124T151245
CREATED:20220426T222843Z
LAST-MODIFIED:20230822T172608Z
UID:8924-1697194800-1697198400@www.centreforbrainhealth.ca
SUMMARY:Dr. Denise Cai: The brain in motion: stability and flexibility of memory engrams across time and experience
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nCreating stable memories is critical for survival. An animal relies on past learning to navigate its environment\, avoid dangerous situations\, and find needed resources. Because the environment is dynamic\, stable memories must be updated with new information to enable responses to changing threats (a specific danger) and rewards (such as food and water). The brain circuits involved in memory and learning require both stability and flexibility. Using in vivo calcium imaging and chemogenetics\, we demonstrate how new information is updated with past memories through co-reactivation of memory ensembles during offline periods including sleep.
URL:https://www.centreforbrainhealth.ca/events/dr-denise-cai/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231006T110000
DTEND;TZID=America/Vancouver:20231006T120000
DTSTAMP:20231124T151245
CREATED:20230921T193033Z
LAST-MODIFIED:20230921T193101Z
UID:11887-1696590000-1696593600@www.centreforbrainhealth.ca
SUMMARY:Dr. Julia Schulze-Hentrich: At the nexus of genes\, aging and environment: Understanding transcriptomic and epigenomic regulation in health and disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe DNA of every cell in our body contains the genes inherited from our parents and plays a crucial role in health and disease. While changes in the DNA itself are linked to monogenic diseases\, they often fail to explain complex disorders such as neurodegenerative diseases. This can potentially be explained by additional layers of gene regulation known to be stored “above” the DNA\, at the epigenetic level. Over the last years\, this relatively young research field has shown that molecular structures packaging DNA in the cell nucleus influence gene activity. The DNA itself as well as its packaging structure\, the so-called chromatin\, can be chemically modified in many ways and is highly dynamic. With these findings\, chromatin appears to be a central interface between genes and the environment\, and the development and progression of diseases could be decisively influenced by epigenetic changes. Our research group investigates which epigenetic modifications are associated with complex neurological diseases – in particular Parkinson’s and Huntington’s – and how environmental factors and aging have modulating effects on them. Here\, I will give an overview of current projects and highlight key findings of our work. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-julia-schulze-hentrich/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230929T110000
DTEND;TZID=America/Vancouver:20230929T120000
DTSTAMP:20231124T151245
CREATED:20220604T014843Z
LAST-MODIFIED:20230822T172524Z
UID:9076-1695985200-1695988800@www.centreforbrainhealth.ca
SUMMARY:Dr. Richard Mooney: From song to synapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nVocalizations are an essential medium for social and sexual signaling in mammals and birds.  Whereas most animals only produce innate vocalizations\, songbirds learn to sing in a process with many parallels to human speech learning. I will discuss recent advances from our lab highlighting the neural mechanisms that enable birdsong learning\, including basal ganglia-dependent vocal exploration and reinforcement. How the learned song is integrated with innate vocalizations will also be considered\, with reference to recent studies that genetically map neural circuits for innate vocalizations in mice. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-richard-mooney/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230922T110000
DTEND;TZID=America/Vancouver:20230922T120000
DTSTAMP:20231124T151245
CREATED:20230725T202300Z
LAST-MODIFIED:20230822T172441Z
UID:11438-1695380400-1695384000@www.centreforbrainhealth.ca
SUMMARY:Dr. Jibran Khokhar: Cannabis and the Vulnerable Brain: A Closer Look at Genetics\, Adolescence\, and Edible Overdose
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Khokhar will talk about the behavioural and neural correlates of various types of vulnerabilities to cannabis\, starting from genetic risk for cannabis use\, to vaping in adolescence\, to the recent increases in edible overdoses in children and pets.
URL:https://www.centreforbrainhealth.ca/events/dr-jibran-khokhar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230915T110000
DTEND;TZID=America/Vancouver:20230915T120000
DTSTAMP:20231124T151245
CREATED:20220706T204712Z
LAST-MODIFIED:20230901T170859Z
UID:9251-1694775600-1694779200@www.centreforbrainhealth.ca
SUMMARY:Dr. Maya Koronyo: Retinal manifestations of Alzheimer’s disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe neural retina is a key organ for vision and visual processing. As a direct extension of the brain\, it emerges as a prominent site impacted by Alzheimer’s disease (AD).  The retina is the only CNS tissue not shielded by bone that can be easily accessible for noninvasive\, affordable\, ultra-high-resolution imaging in the clinical setting. Data from recent years strongly suggest it can serve as a window to assess AD. Early studies described retinal nerve fiber layer and ganglion cell degeneration. Our team revealed the accumulation of core AD hallmarks—amyloid β-protein (Aβ) plaques and neurofibrillary tangles—in the retina of AD and mild cognitive impairment (MCI) patients. Subsequent studies confirmed these findings\, and further reported visual and electroretinography abnormalities\, retinal tauopathy\, Aβ oligomers\, inflammation\, and cell-specific degeneration in AD patients. Data from our group and others suggest that the brain and retina follow a similar trajectory during AD progression\, potentially due to their shared embryonic origin and anatomical proximity. Moreover\, retinal vascular irregularities—vessel density and fractal dimensions\, blood flow\, foveal avascular zone\, curvature tortuosity\, arteriole-to-venule ratio—are present in AD patients\, including early-stage cases. A tight association between cerebral and retinal vasculopathy to cognitive deficits was reported in AD patients and animal models. More recently\, we identified early and progressive retinal vascular platelet-derived growth factor receptor-β (PDGFRβ) deficiency and pericyte loss\, as well as retinal endothelial tight junction losses in MCI and AD patients. These retinal vasculopathies strongly link to vascular amyloid accumulation as well as could predict the severity of cerebral amyloid angiopathy. Currently\, we explore the complex landscape of Alzheimer’s in the retina\, including AD-related molecular signatures and processes\, new forms of proteinopathies\, vascular and inflammatory abnormalities\, synaptic loss\, as well as cell-specific vulnerability and resilience. Establishing how early retinal biomarkers can be detected during AD continuum and what do they mean for brain pathology and functional decline\, should guide the development of future retinal imaging technologies to improve early\, noninvasive AD diagnosis and monitoring. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-maya-koronyo/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230908T110000
DTEND;TZID=America/Vancouver:20230908T120000
DTSTAMP:20231124T151245
CREATED:20220713T185639Z
LAST-MODIFIED:20230822T172316Z
UID:9307-1694170800-1694174400@www.centreforbrainhealth.ca
SUMMARY:Dr. Linda Overstreet-Wadiche: Adult-born neurons in the hippocampal network
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe adult dentate gyrus continually produces new neurons that integrate into the hippocampal circuit. Adult-born neurons transiently exhibit distinct cellular properties that distinguish them from the larger population of mature neurons\, and these properties are thought to underlie the vital role of neurogenesis in hippocampal behaviors. I will review the developmental trajectory of adult-born neuron cellular properties and present new data focused on cellular mechanisms of “critical periods” for plasticity and information processing. The results support the idea that neurogenesis provides a substrate for experience-dependent circuit plasticity and memory precision.
URL:https://www.centreforbrainhealth.ca/events/dr-linda-overstreet-wadiche-2/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230602T110000
DTEND;TZID=America/Vancouver:20230602T120000
DTSTAMP:20231124T151245
CREATED:20210722T000000Z
LAST-MODIFIED:20230412T180627Z
UID:3750-1685703600-1685707200@www.centreforbrainhealth.ca
SUMMARY:Dr. Hokto Kazama: Representations and circuits for opposing odor values in the brain
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nOdors are intrinsically associated with values ranging from positive to negative as they induce innate behaviors such as attraction and aversion. However\, how opposing\, innate values of odors are represented and computed in the brain remains unclear. We are addressing this question in the olfactory circuit of fruit fly Drosophila\, by combining a behavioral analysis in virtual reality\, an imaging technique to track the activity of effectively all the neurons in each brain region\, a connectome analysis\, and simulation. I will discuss our latest findings on distinct subcircuits in the higher-order region that possess different connectivity motifs and compute opposing values of odors.
URL:https://www.centreforbrainhealth.ca/events/dr-hokto-kazama/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230512T110000
DTEND;TZID=America/Vancouver:20230512T120000
DTSTAMP:20231124T151245
CREATED:20230109T181911Z
LAST-MODIFIED:20230404T190800Z
UID:10236-1683889200-1683892800@www.centreforbrainhealth.ca
SUMMARY:Dr. Christopher Pack: Cortical basis of visual learning\, fast and slow
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHubel & Wiesel famously showed that the adult visual cortex changes very little with experience\, and yet we are capable of learning to recognize new faces and places throughout our lives. I will describe recent work that examines the brain changes that accompany learning of a new visual stimulus or visual behaviour. Most changes occur slowly\, over days or weeks\, and these involve altered connections between visual cortex areas and higher-level cortical regions. Under appropriate conditions\, we can observe learning that is very fast\, on a time-scale of minutes\, despite involving similar brain circuits. I will discuss potential applications to visual perception in healthy subjects and rehabilitation following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-christopher-pack/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230505T110000
DTEND;TZID=America/Vancouver:20230505T120000
DTSTAMP:20231124T151245
CREATED:20220604T014752Z
LAST-MODIFIED:20230411T201632Z
UID:9074-1683284400-1683288000@www.centreforbrainhealth.ca
SUMMARY:Dr. Yingxi Lin: Active Neuronal Ensembles
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHow are transient experiences converted into long-lasting memories? How do experiences modify behaviors? How do similar experiences elicit drastically different behavioral responses in the healthy and disease states? These are some of the questions that drive the research in my lab. We particularly focus on the mechanisms underlying the reconfiguration of neural circuits following sensory and behavioral experiences that leads to functional adaptation. While we know in many cases the brain regions that are involved\, the identity of the neurons that encode the information and the particular information that is processed are not easy to determine with standard molecular or systems approaches. To overcome these challenges my lab has developed a new set of genetic tools that have enabled us to genetically identify neuronal ensembles activated by sensory and behavioral experiences\, uncover essential circuit components involved in different aspects of learning and memory\, and explore the mechanisms by which learning is specifically coupled to synaptic changes on these ensembles to achieve behavioral adaptation. My talk will highlight both published and ongoing studies in my lab. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-yingxi-lin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230428T110000
DTEND;TZID=America/Vancouver:20230428T120000
DTSTAMP:20231124T151245
CREATED:20220426T223214Z
LAST-MODIFIED:20230127T185916Z
UID:8926-1682679600-1682683200@www.centreforbrainhealth.ca
SUMMARY:Dr. Stuart Trenholm: A day in the life of a blind mouse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIt is well established that after vision loss\, capabilities of the other sensory systems can be enhanced. However\, particularly in animal models of vision loss\, little has been done to examine how vision loss leads to alterations in the ‘blind brain’\, and how these changes affect an animal’s behavior. Here I will discuss our recent work describing changes in neuronal activity and animal behaviour in mice following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-stuart-trenholm/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230421T110000
DTEND;TZID=America/Vancouver:20230421T120000
DTSTAMP:20231124T151245
CREATED:20221025T210816Z
LAST-MODIFIED:20230411T233932Z
UID:9816-1682074800-1682078400@www.centreforbrainhealth.ca
SUMMARY:Dr. Jesse Jackson: Examining the anatomy\, physiology\, and function of claustrum-cortical neurons
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe claustrum is a small brain region forming dense synaptic connections with most of the cerebral cortex. However\, the function of this region remains a mystery. I will highlight recent work from our group mapping the connectivity of claustrum neurons and determining how these cells control distinct cortical modules to participate in cognitive functions such as memory.
URL:https://www.centreforbrainhealth.ca/events/dr-jesse-jackson/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230414T110000
DTEND;TZID=America/Vancouver:20230414T120000
DTSTAMP:20231124T151245
CREATED:20220620T202725Z
LAST-MODIFIED:20230224T214943Z
UID:9135-1681470000-1681473600@www.centreforbrainhealth.ca
SUMMARY:Dr. Jared Young: Crossing the death valleys of the translational continuum: Coupling domain specificity with clinical sensitivity
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe vast majority of drugs fail when trying to go from animals to humans.  Some fields fail more than others\, with psychiatry being at the pinnacle of a competition no field wants to win.  Understanding behavior has been difficult enough\, delineating what went awry at the genetic and environmental level throughout development\, to give rise to a myriad of disorders characterized by their behavior – is there a haystack big enough for that one needle?  Then developing drugs targeting those mechanisms?  First and foremost it is our job to delineate neural mechanisms underlying normal behavior.  To do that\, we must utilize tasks with domain-task specificity\, wherein we are confident that the cognitive domain measured in animals matches that tested in humans.  We can validate these tasks\, examining their face\, predictive (including pharmacological)\, and neurobiological validities.  For treatment development\, we also need to make sure that it is a domain worth targeting – do patients exhibit deficient performance\, does the task have clinical sensitivity?  I will present data we have generated over the past two decades demonstrating this process\, how translational task-development can work in forward and reverse\, how working with clinicians enabled testing the clinical sensitivity of even some of the simplest tasks in rodents such as exploration\, and effortful motivation.  This work culminates in testing potential treatments that patients guide us toward\, such as cannabis for attenuating risk-taking in people with bipolar disorder.  Thus\, from potential pharmacotherapies\, more targeted treatments can be through this use of domain specificity in testing.
URL:https://www.centreforbrainhealth.ca/events/dr-jared-young/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230331T110000
DTEND;TZID=America/Vancouver:20230331T120000
DTSTAMP:20231124T151245
CREATED:20210722T000000Z
LAST-MODIFIED:20230320T224544Z
UID:3747-1680260400-1680264000@www.centreforbrainhealth.ca
SUMMARY:Dr. Joseph Cheer: Endogenous cannabinoids and the pursuit of reward
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn the early stages of substance abuse\, subjects receive a drug that is highly reinforcing and are thus likely to repeat the actions that led them to obtain it.  This is termed positive reinforcement. However\, in a minority of people who develop an addiction phenotype\, negative reinforcement also causes a behavior to be repeated\, but in this case\, the action causes a bad feeling or situation to go away. The mesolimbic dopamine system\, which is thought to generate a teaching signal\, is involved in the selection of advantageous behavioral repertoires. This brain pathway is under control of endocannabinoid (eCBs)\, ubiquitous signaling molecules that bind to the same receptor targeted by marijuana (CB1) known to strengthen responses leading to the procurement of reward. Here\, we investigate how eCBs modulate dopaminergic encoding of cues predicting either\, appetitive stimuli\, the avoidance of punishment or aversive outcomes. We find that disrupting eCB signaling by treating animals with a CB1 receptor antagonist dose-dependently decreased concentrations of dopamine release in the nucleus accumbens that were time-locked to a warning signal that predicts avoidance of punishment while simultaneously weakening shock avoidance behavior\, effectively shifting the behavioral outcome from avoidance to escape. We further demonstrate\, using directed mutagenesis approaches\, that 2AG release from dopamine neurons in the midbrain is a canonical mechanism responsible for the pursuit of rewards. \nIt has been posited that compromised motivation in HD or “apathy” arises from a deficit in preparing for and initiating goal-directed behavior. Apathy is always the primary deficit in motivation associated with frontal-subcortical diseases such as HD. Indeed\, apathy may be a core feature of HD disease pathology itself. In many cases apathy follows a similar trajectory as motor symptom progression in PD\, although it can become prevalent before phenoconversion. It can be the result of several neurobiologically maladaptive systems\, including affective (flattening of emotional responsiveness)\, behavioral (reduced initiation of spontaneous behavior)\, and executive dysfunction (difficulty planning/executing). Thus\, motivational dysfunction in HD is a deficit primarily in preparation for motivated behavior that can have debilitating co-morbid consequences. \nGaps in knowledge \n\nLoss of striatal cannabinoid type 1 (CB1) receptors is a key pathogenic of several neurodegenerative diseases\, including HD.\nTreatment for metabolic syndrome with the CB1 receptor antagonist Rimonabant was halted by the FDA because of loss of motivation and depressive ideation.\nHD patients tend to smoke marijuana as a way to self-medicate and to prevent feelings of loneliness and helplessness.\nLoss of goal-directed behavior in HD is specific to the incentive value of the reinforcer.\nTreatment with indirect cannabinoid agonists profoundly increases operationally defined indices of motivation in normal animals and reverses apathy via dopaminergic mechanisms in mouse models of HD.\n\nTogether these data suggest that eCBs might modify distinct behavioral responses related to exteroceptive stimuli by modulating conditioned mesolimbic dopamine release events.  These findings suggest that therapies aimed at modifying tissue levels of eCBs may be used to prevent drug seeking driven by negative affective states or improve motivational indices in animal models of HD. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-joseph-cheer/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230324T110000
DTEND;TZID=America/Vancouver:20230324T120000
DTSTAMP:20231124T151245
CREATED:20221201T201738Z
LAST-MODIFIED:20230117T213557Z
UID:10052-1679655600-1679659200@www.centreforbrainhealth.ca
SUMMARY:Dr. Kathleen Morrison: Role for chromatin remodeling in the lifelong consequences of pubertal adversity on the brain and behavior
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nPuberty and ensuing adolescence represent a time when the brain is rapidly developing and is sensitive to environmental stimuli. This lecture will discuss evidence that pubertal adversity puts females at risk for altered stress responding and maternal behavior later in life. Evidence will be presented that pubertal stress leads to an enduring programmatic event in the chromatin landscape in several brain regions\, which may underlie both the lasting transcriptomic and behavioral consequences of pubertal stress.
URL:https://www.centreforbrainhealth.ca/events/dr-kathleen-morrison/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230317T110000
DTEND;TZID=America/Vancouver:20230317T120000
DTSTAMP:20231124T151245
CREATED:20210722T000000Z
LAST-MODIFIED:20230109T182025Z
UID:3748-1679050800-1679054400@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael Drew: Hippocampal mechanisms of fear suppression and relapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nLearned fear often relapses after extinction\, suggesting that extinction training generates a new memory that coexists with the original fear memory. Recent work from our lab has identified the hippocampus as a region where such fear and extinction memories exist and compete for expression. In this talk I will discuss recent work in our lab in which we have used activity-dependent neural tagging in mice to identify\, manipulate\, and characterize the cellular mechanisms of these hippocampal fear and extinction memories. I will discuss (1) where in the hippocampus these memory representations exist\, (2) evidence that fear and extinction memories are coded by molecularly distinct cell ensembles\, and (3) evidence that expression of fear and extinction is mediated by activation unique hippocampal output pathways.
URL:https://www.centreforbrainhealth.ca/events/dr-michael-drew/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230310T110000
DTEND;TZID=America/Vancouver:20230310T120000
DTSTAMP:20231124T151245
CREATED:20220714T200422Z
LAST-MODIFIED:20230308T233026Z
UID:9317-1678446000-1678449600@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Neha Suvindran and Drs. Rebecca Todd & Stan Floresco
DESCRIPTION:Neha Suvindran: “Reimagining Neuro-Bioelectronic Systems: Sustainable\, Stable and Self-healing Fiber Electrodes”\nDrs. Rebecca Todd and Stan Floresco: “Translation Investigation of Neurophysiological Substrates of Active and inhibitory Avoidance in healthy and depressed populations.”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-neha-suvindran-and-rebecca-todd/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230303T110000
DTEND;TZID=America/Vancouver:20230303T120000
DTSTAMP:20231124T151245
CREATED:20220714T200002Z
LAST-MODIFIED:20230302T010113Z
UID:9315-1677841200-1677844800@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Drs. Annie Ciernia and Paul van Donkelaar
DESCRIPTION:Dr. Annie Ciernia: “Mechanisms of Peripheral Lipopolysaccharide Induced Brain Inflammation”\nDr. Paul van Donkelaar: “Characterizing tau pathology in survivors of intimate partner violence-related traumatic brain injury”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-drs-annie-ciernia-and-paul-van-donkelaar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230224T110000
DTEND;TZID=America/Vancouver:20230224T120000
DTSTAMP:20231124T151245
CREATED:20220708T172733Z
LAST-MODIFIED:20230210T001332Z
UID:9281-1677236400-1677240000@www.centreforbrainhealth.ca
SUMMARY:Dr. Joni Wallis: Neuronal mechanisms of value-based decision-making: a brain-machine interface approach
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDecision-making is an unobservable cognitive process. This makes it challenging to investigate the underlying neuronal mechanisms. This lecture will discuss how techniques borrowed from the brain-machine interface field\, such as decoding population activity and closed-loop control\, can be used to understand how cognitive processes such as decision-making are implemented at the neuronal level. This approach could also lead to the development of novel devices for the treatment of neuropsychiatric disorders that involve impaired decision-making.
URL:https://www.centreforbrainhealth.ca/events/dr-joni-wallis/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230203T110000
DTEND;TZID=America/Vancouver:20230203T120000
DTSTAMP:20231124T151245
CREATED:20220704T174420Z
LAST-MODIFIED:20230105T182151Z
UID:9207-1675422000-1675425600@www.centreforbrainhealth.ca
SUMMARY:Dr. Anastassia Voronova: (Re)generating oligodendrocytes in the developing and degenerating brain: a neural stem cell perspective
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nObjectives: \n1) Neural stem cells build and regenerate the brain in part by forming oligodendrocytes\, the myelinating cells of the central nervous system \n2) Endogenous neural stem cells can be engaged in mouse models of neurodegenerative disorders for brain remyelination \n3) Neurodegenerative disorders may have a neurodevelopmental origin\, and neurodevelopmental disorders may have a neurodegenerative component.
URL:https://www.centreforbrainhealth.ca/events/dr-anatassia-voronova/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230120T110000
DTEND;TZID=America/Vancouver:20230120T120000
DTSTAMP:20231124T151245
CREATED:20220519T204558Z
LAST-MODIFIED:20230119T223200Z
UID:9022-1674212400-1674216000@www.centreforbrainhealth.ca
SUMMARY:Dr. Yuki Oka: Regulation of fluid homeostasis through gut-brain signaling
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Oka will discuss how innate instinct to consume water and salt is regulated through body-brain interactions.
URL:https://www.centreforbrainhealth.ca/events/dr-yuki-oka/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR