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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221125T110000
DTEND;TZID=America/Vancouver:20221125T120000
DTSTAMP:20231124T144053
CREATED:20220706T193133Z
LAST-MODIFIED:20221025T234333Z
UID:9239-1669374000-1669377600@www.centreforbrainhealth.ca
SUMMARY:Dr. Fabian Voigt: Expanding the optical bag of tricks for neuroscience 
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nSeeing is believing and thus\, optical imaging techniques are extremely useful to study brain structure and function. I will present two projects aimed at providing the neuroscience community with better imaging instrumentation. In the first part\, I will introduce the mesoSPIM ( http://mesospim.org/ )\, an open-source light-sheet microscope that is optimized for fast imaging of large cleared tissue samples at 5-7 µm isotropic resolution. Since 2015\, the mesoSPIM evolved from a crude prototype into a highly capable instrument and we built a global community around it. Currently\, we are developing a benchtop mesoSPIM that is more compact and cost-efficient. In the second part\, I will talk about a recent project that takes inspiration from scallops and astronomy to build novel multi-immersion microscope objectives that are well suited for imaging cleared samples. These objectives combine long working distances (>1 cm)\, large FOVs (>1 mm)\, high numerical aperture (currently up to 1.08) with diffraction-limited resolution in any homogeneous medium ranging from air to the typical high-index immersion liquids used for imaging cleared tissue. They are especially well suited to augment low-to-mid resolution mesoSPIM overviews with high-resolution datasets.
URL:https://www.centreforbrainhealth.ca/events/dr-fabian-voigt/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221118T110000
DTEND;TZID=America/Vancouver:20221118T120000
DTSTAMP:20231124T144053
CREATED:20220706T193905Z
LAST-MODIFIED:20221027T193214Z
UID:9113-1668769200-1668772800@www.centreforbrainhealth.ca
SUMMARY:Drs. George Augustine\, Lim Kah Leong and Nagaendran Kandiah
DESCRIPTION:Professor George Augustine –  Nanyang Technological University\, Singapore\nTalk Title: “Synapses and synaptic circuits in health and disease”\nProfessor Lim Kah Leong – Nanyang Technological University\, Singapore\nTalk Title: “Neuroprotective and neurorestorative strategies for Parkinson’s disease”\nProfessor Nagaendran Kandiah –  Nanyang Technological University\, Singapore\nTalk Title: “Fluid biomarker and neuroimaging profile of mild cognitive impairment in Southeast Asians”\n\nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/nanyang-technological-university/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221104T110000
DTEND;TZID=America/Vancouver:20221104T120000
DTSTAMP:20231124T144053
CREATED:20220706T174256Z
LAST-MODIFIED:20221025T234203Z
UID:9233-1667559600-1667563200@www.centreforbrainhealth.ca
SUMMARY:Dr. Ryan McLaughlin: Lost in Translation: Leveraging Preclinical Models to Interrogate Effects of Developmental Cannabis Exposure
DESCRIPTION:Maternal cannabis use is a growing public health concern\, yet the long-term effects of prenatal cannabis exposure remain elusive. Our understanding of how prenatal cannabis exposure affects the brain and behavior is critically informed by preclinical animal models that capture core components of human cannabis use. To this end\, our laboratory and others have recently developed more translational models of cannabis use that have potential to provide unprecedented insight into the protracted effects of cannabis exposure during sensitive developmental stages.  In this presentation\, I will describe recent data from our laboratory using a novel model of cannabis vapor self-administration in pregnant rat dams to investigate the long-term effects of maternal cannabis use on emotional reactivity\, cognitive flexibility\, and cannabis-seeking behavior. Additionally\, I will present emerging data from our laboratory revealing altered excitatory inputs onto corticostriatal projection neurons in cannabis-exposed adult offspring\, which could represent a mechanism by which prenatal cannabis exposure impacts reward-relevant behavior. Altogether\, our data support the use of the cannabis vapor self-administration approach to investigate long-term effects of maternal cannabis use in developing offspring. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\n 
URL:https://www.centreforbrainhealth.ca/events/dr-ryan-mclaughlin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221028T110000
DTEND;TZID=America/Vancouver:20221028T120000
DTSTAMP:20231124T144053
CREATED:20220604T014447Z
LAST-MODIFIED:20221025T234115Z
UID:9070-1666954800-1666958400@www.centreforbrainhealth.ca
SUMMARY:Dr. Mihaela Iordanova: Neurobiology of secondary fear triggers
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nThe study of how the brain regulates learned fear has been fundamental to understanding brain function and has served as a pre-clinical animal model for fear- and anxiety-related disorders in humans. The current model has exclusively focused on primary triggers for fear\, that is\, fear acquired through direct pairings between a cue and a fear-eliciting event. However\, fear is also elicited by secondary triggers\, that is\, cues that were never directly paired with the aversive event. These secondary triggers gain fear-eliciting properties by virtue of their association with primary triggers. The talk will present data showing how fear memories propagate across the memory network allowing for the development of secondary fear triggers\, how those memories are regulated by fear to the primary triggers at the behavioural and neural level\, as well as how they are supported by circuits in the brain.
URL:https://www.centreforbrainhealth.ca/events/dr-mihaela-iordanova/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221024T153000
DTEND;TZID=America/Vancouver:20221024T170000
DTSTAMP:20231124T144053
CREATED:20221018T000659Z
LAST-MODIFIED:20221018T000659Z
UID:9725-1666625400-1666630800@www.centreforbrainhealth.ca
SUMMARY:Investigating anticipatory and consummatory reward underlying anhedonia in mood disorders
DESCRIPTION:This month\, Cecilia Yu from the Chakrabarty Lab in the Department of Psychiatry will present on “Investigating anticipatory and consummatory reward underlying anhedonia in mood disorders.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/investigating-anticipatory-and-consummatory-reward-underlying-anhedonia-in-mood-disorders/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/10/Mental-Health-IRP-rounds-Oct-24-2022-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221021T110000
DTEND;TZID=America/Vancouver:20221021T120000
DTSTAMP:20231124T144053
CREATED:20220604T014344Z
LAST-MODIFIED:20220805T201802Z
UID:9068-1666350000-1666353600@www.centreforbrainhealth.ca
SUMMARY:Dr. Anthony Filiano: Regulating the Brain from Its Borders
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nThe CNS is an immune-privileged organ\, yet we know that peripheral immunity is critical for proper brain function. Here we will discuss cell communications in the meninges that regulate patrolling T cells and how the brain responds to T cell-derived signals.
URL:https://www.centreforbrainhealth.ca/events/dr-anthony-filiano/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221014T110000
DTEND;TZID=America/Vancouver:20221014T120000
DTSTAMP:20231124T144053
CREATED:20220604T014225Z
LAST-MODIFIED:20220805T201827Z
UID:9066-1665745200-1665748800@www.centreforbrainhealth.ca
SUMMARY:Dr. Eric Yttri: Understanding brain-wide circuit dynamics underlying learned and spontaneous behavior with B-SOiD
DESCRIPTION:For decades\, neuroscience has focused almost exclusively on stereotyped\, reductionist\, and over-trained behaviors due to their ease of study. In contrast\, naturalistic behavior provides a rich diversity of movements\, but this feature also largely precludes it from quantification and use. Recent advances in computer vision have enabled automatic tracking of the position of body parts – but position is not behavior. To provide a bridge from positions to behaviors and their kinematics\, we developed B-SOiD (Hsu and Yttri\, Nature Communications). This open-source method discovers natural spatiotemporal patterns in body position data\, then uses the cluster statistics to train a machine learning algorithm to classify behaviors that can generalize across subjects and labs. We will discuss the application of this user-friendly algorithm in flies\, mice\, and humans. Finally\, we will share new data from recordings throughout the cortex and basal ganglia that reveal how these diverse behaviors are encoded by single units and interconnected neural populations. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\n  \n 
URL:https://www.centreforbrainhealth.ca/events/dr-eric-yttri/
LOCATION:British Columbia
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220926T153000
DTEND;TZID=America/Vancouver:20220926T170000
DTSTAMP:20231124T144053
CREATED:20220909T184753Z
LAST-MODIFIED:20220909T184753Z
UID:9579-1664206200-1664211600@www.centreforbrainhealth.ca
SUMMARY:Effects of cannabinoids on stress response in young adult heavy drinkers: An ongoing placebo-controlled neuroimaging trial
DESCRIPTION:This month\, Karina Thiessen from the Schütz Lab in the Department of Psychiatry will present on “Effects of cannabinoids on stress response in young adult heavy drinkers: An ongoing placebo-controlled neuroimaging trial.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/effects-of-cannabinoids-on-stress-response-in-young-adult-heavy-drinkers-an-ongoing-placebo-controlled-neuroimaging-trial/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/09/Mental-Health-IRP-rounds-Sept-26.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220923T110000
DTEND;TZID=America/Vancouver:20220923T120000
DTSTAMP:20231124T144053
CREATED:20220604T014013Z
LAST-MODIFIED:20220808T163820Z
UID:9064-1663930800-1663934400@www.centreforbrainhealth.ca
SUMMARY:Dr. Eugenii A. (Ilan) Rabiner: Molecular Imaging in CNS drug development
DESCRIPTION:Zoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nOver the past 25 years the costs of drug development have been rising steeply\, with later phases being particularly resource intensive. Molecular imaging (primarily PET) has become an indispensable tool in early phase drug development\, especially for compounds focused on CNS targets\, PET studies conducted at an appropriate enable the refinement of the dose range to be explored in later phase studies\, leading to time and resource savings\, as well as providing early demonstration of compounds that are going to fail\, leading to early termination and the reallocation of considerable resources. This talk will discuss the application of PET and MR imaging in early phase drug development\, within the framework of the “three pillars” of drug development and provide examples of such studies.
URL:https://www.centreforbrainhealth.ca/events/dr-eugenii-a-ilan-rabiner/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220916T110000
DTEND;TZID=America/Vancouver:20220916T120000
DTSTAMP:20231124T144053
CREATED:20220604T013819Z
LAST-MODIFIED:20220815T171642Z
UID:9062-1663326000-1663329600@www.centreforbrainhealth.ca
SUMMARY:Dr. Kim Green: Exploring  microglia  function  in  the healthy and Alzheimer’s disease brain
DESCRIPTION:Microglia are the primary immune cell of the brain\, but have roles outside of immunity as well as being implicated in the pathogenesis of many CNS disorders. Here I will show how we can use CSF1R inhibitors to control the microglial population in vivo\, and elucidate their functions in both the homeostatic and disease brains. I will focus on the involvement of microglia in Alzheimer’s disease\, and also detail several new genetic models to understand the disease progression. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-kim-green/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220909T110000
DTEND;TZID=America/Vancouver:20220909T120000
DTSTAMP:20231124T144053
CREATED:20220604T013640Z
LAST-MODIFIED:20220805T201639Z
UID:9060-1662721200-1662724800@www.centreforbrainhealth.ca
SUMMARY:Dr. Anke Henning: Metabolic MRI at ultra-high fields – from systems architecture to application
DESCRIPTION:Metabolic MRI allows observing energy metabolism\, neurotransmission\, second messaging\, endocrine signaling\, antioxidants\, protein metabolism and dynamic membrane processes in the human brain. Related quantitative metabolic imaging biomarkers are beneficial for differential diagnostics\, monitoring of treatment response and patient stratification in various neurological and psychiatric disorders and yield complementary information to structural and functional imaging. To visualize related metabolic processes my research group develops methodology for highly spatially and temporally resolved metabolic imaging exploiting magnetic resonance spectroscopy (MRS)\, chemical exchange saturation transfer (CEST) and non-proton spectroscopic imaging (31P\, 13C\, 2H) at 3T\, 7T and 9.4T with application in the human brain\, spinal cord and myocardium. These methods allows for non-invasive and non-ionizing determination of tissue concentrations and metabolic turn-over rates of more than 20 metabolites and ions and specifically benefits from ultrahigh field strength with regard to spectral resolution and signal-to-noise ratio. \nHowever\, specific physical and technical challenges have to be overcome to fully exploit the advantages of ultrahigh field MR at 7T and 9.4T for human MRI and MRS. Hence my laboratory invests into the development of enabling technology for ultrahigh field MRI including scan hardware such as radiofrequency coils and static magnetic field shimming\, numerical optimization of these setups and is able to perform respective safety assessment to allow for application in humans. The lab also develops scan software including MRI sequences and is able to design tailored radiofrequency pulse including such dedicated to parallel transmission systems. Specifically for metabolic MRI we also develop tailored data analysis methods such as image reconstruction\, post-processing and quantification pipelines and recently started to explore machine-learning based approaches. \nThis presentation gives an overview over our recent research activities. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-anke-henning/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220713T150000
DTEND;TZID=America/Vancouver:20220713T163000
DTSTAMP:20231124T144053
CREATED:20220622T224917Z
LAST-MODIFIED:20220622T225111Z
UID:9151-1657724400-1657729800@www.centreforbrainhealth.ca
SUMMARY:R/RStudio Workshop
DESCRIPTION:Join us Wednesday\, July 13th at 3:00 pm for our Intro to R Workshop – Part 2\, presented by the UBC Databinge Data Champions Team. \nZoom link: https://ubc.zoom.us/s/64233269929 \nMeeting ID: 642 3326 9929\nPasscode:  476508 \n  \nWho should attend this workshop? \n\n​Trainees who want practice making computationally reproducible workflows\nTrainees who want to learn how to use tools like RStudio\, Open Science Framework and Github\nTrainees who want to become more comfortable performing variations of the t-test (e.g.\, one sample\, two sample\, paired) and non-parametric tests (e.g.\, Wilcoxon Rank Sum test\, Permutation test)\nTrainees who want to learn about other statistical methods\, including: ANOVA\, assessing null hypotheses and p-values\, and Bootstrapping\n\nWhat level of coding/R experience is required for this workshop? \n​This workshop requires little to no coding/R experience. All of the coding tasks included will be made as simple as possible and we will guide you through step by step. The R coding tasks will involve: using bash to download data\, using basic functions in R\, manipulating dataframes\, creating plots using ggplot2\, making t-tests and its variations\, and using power calculations. \nDo I need to do anything before attending the tutorial? \n​Yes\, there are just a couple of steps needed to prepare! \n\nInstall R if you have not already:\nhttps://cran.r-project.org/ \nIf you have R installed but have not used it in over a year we suggest that you update R via reinstalling it.\nInstall RStudio if you have not already: https://rstudio.com/products/rstudio/download/#download\nIf you are on Windows\, you will need to download Windows Subsystem for Linux (WSL): https://docs.microsoft.com/en-us/windows/wsl/install.\nIf you are on Mac\, you can do the equivalent by downloading Homebrew: https://brew.sh.\nInstall the following R packages (open RStudio and copy and paste the following commands into the console):\nInstall.packages(“ggpubr”)\nInstall.packages(“tidyverse”)\nInstall.packages(“coin”)\n\nI missed Part I of the R workshop\, how do I participate? \nPart I of the workshop can be found both at the UBC Brain Circuits GitHub repository and the UBC Brain Circuits YouTube page. The YouTube videos guide you through the files and data provided on GitHub. \nWhat if I’m interested in learning about this but I can’t make it today? \n​We always post our tutorial materials on our GitHub repository after the workshop is finished! Feel free to download the Rmd file and work through it at your own pace. Please feel free to come to the Brain Circuits Databinge to ask any follow-up questions. \nWe hope to see you there! Feel free to email us at jledue@mail.ubc.ca with any questions.
URL:https://www.centreforbrainhealth.ca/events/r-rstudio-workshop/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220627T153000
DTEND;TZID=America/Vancouver:20220627T170000
DTSTAMP:20231124T144053
CREATED:20220620T192047Z
LAST-MODIFIED:20220620T192427Z
UID:9132-1656343800-1656349200@www.centreforbrainhealth.ca
SUMMARY:How emotional context influences memory for neutral scene details in a non-clinical sample of young adults: Implications for trauma-related disorders
DESCRIPTION:This month\, Chantelle Cocquyt from the Palombo Lab in the Department of Psychology will present on “How emotional context influences memory for neutral scene details in a non-clinical sample of young adults: Implications for trauma-related disorders.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/how-emotional-context-influences-memory-for-neutral-scene-details-in-a-non-clinical-sample-of-young-adults/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/06/Mental-Health-IRP-rounds-June-27.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220601T150000
DTEND;TZID=America/Vancouver:20220603T120000
DTSTAMP:20231124T144053
CREATED:20220314T201735Z
LAST-MODIFIED:20220531T224400Z
UID:8473-1654095600-1654257600@www.centreforbrainhealth.ca
SUMMARY:2022 DMCBH Research Retreat
DESCRIPTION:We are looking forward to hosting this Research Retreat at UBC Okanagan! This event is open to all DMCBH members\, postdoctoral fellows\, research associates\, PhD and MSc students affiliated with the DMCBH. \nREGISTRATION:  \nPlease note that registration has now closed. However\, there are a limited number of spots remaining – please contact Clement Woo if you are still interested in attending. \nA $100 fee will be applied to people who cancel without a valid reason after May 16 or who do not show up. \n  \nRetreat details:\n\nThe retreat will consist of a series of talks from both DMCBH members and trainees as well as a poster session.\nDMCBH members will be directly invited by the Retreat Committee to present their work\, and trainee talks will be selected from submitted abstracts. (Please note that only trainees who have enough data to present for 10 minutes should indicate their willingness to give a talk.)\nThere will be a reception on both Wednesday and Thursday evening.\nAccommodations at UBC Okanagan are available at a group rate – BOOK HERE.\n\nIf you have any questions or need to cancel\, please reach out to Clement Woo (clement.woo@ubc.ca) or Vanessa Hrvatin (vanessa.hrvatin@ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/2022-dmcbh-research-retreat/
LOCATION:UBC Okanagan\, 3333 University Way\, Kelowna\, British Columbia\, V1V 1V7\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220513T110000
DTEND;TZID=America/Vancouver:20220513T120000
DTSTAMP:20231124T144053
CREATED:20220412T221303Z
LAST-MODIFIED:20220511T232211Z
UID:8817-1652439600-1652443200@www.centreforbrainhealth.ca
SUMMARY:Dr. Takao Hensch: Balancing Brain Plasticity/Stability
DESCRIPTION:Brain function is largely shaped by experience in early life\, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods\, identifying both “triggers” and “brakes” on plasticity. Strikingly\, the maturation of particular inhibitory circuits is pivotal for the onset timing of these windows. Manipulations of their emergence can either accelerate or delay developmental trajectories regardless of chronological age. Notably\, many neurodevelopmental disorders are linked to alterations in excitatory-inhibitory balance\, suggesting shifted critical period timing as part of their etiology. Closure of critical periods in turn reflects an active process\, rather than a purely passive loss of plasticity factors. Lifting these brakes allows the reopening of plastic windows later in life\, but may also underlie instability in disease states. Thus\, understanding how brain plasticity and stability are balanced throughout life offers new insight into mental illness and novel therapeutic strategies for recovery of function in adulthood. \n\nZoom option if unable to attend in person\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nTo attend the trainee lunch following the seminar or to schedule a meeting with Dr. Hensch\, please email Kim at kschmidt@mail.ubc.ca
URL:https://www.centreforbrainhealth.ca/events/dr-takao-hensch/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/04/Takao-Hensch-presentation-May-13.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220506T110000
DTEND;TZID=America/Vancouver:20220506T120000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185558Z
UID:3749-1651834800-1651838400@www.centreforbrainhealth.ca
SUMMARY:Dr. Elizabeth Heller: Epigenetic regulation of reward pathophysiology
DESCRIPTION:The Heller Lab research program is focused on discovering molecular mechanisms by which epigenetic reprogramming contributes to neuropsychiatric disease. To this end\, Dr. Heller pioneered the use of targeted epigenetic editing in brain\, to elucidate the precise causal role of histone posttranslational modifications on gene expression and alternative splicing in specific neuronal subpopulations. Dr. Heller will share recent studies of epigenetic regulation of gene expression and alternative splicing across cocaine abstinence in mice\, as well as novel approaches to examine histone modifications in specific neuronal subpopulations. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-elizabeth-heller/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220429T110000
DTEND;TZID=America/Vancouver:20220429T120000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220315T212653Z
UID:3745-1651230000-1651233600@www.centreforbrainhealth.ca
SUMMARY:Dr. Nelson Spruston: Neurophysiological mechanisms of memory guided behavior
DESCRIPTION:Mammals use a sophisticated\, multi-regional memory system to guide behavior. A major goal of neuroscience is to understand the mechanisms—ranging from molecular to cellular to systems—that make this possible. Spruston will describe recent results from his lab using mouse behavior\, patch-clamp recording\, imaging\, and RNA-seq\, which collectively seek to elucidate how a diverse and complex population of neurons in the hippocampus allow mice to perform sophisticated memory guided behaviors. \nZoom option if unable to attend in person \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-nelson-spruston/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220425T153000
DTEND;TZID=America/Los_Angeles:20220425T170000
DTSTAMP:20231124T144053
CREATED:20220404T210525Z
LAST-MODIFIED:20220415T003532Z
UID:8744-1650900600-1650906000@www.centreforbrainhealth.ca
SUMMARY:Machine Learning Analyses for Antidepressant Response Prediction
DESCRIPTION:This month\, Dr. John-Jose Nunez (Department of Psychiatry) will present on “Machine Learning Analyses for Antidepressant Response Prediction.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/machine-learning-analyses-for-antidepressant-response-prediction/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/04/Mental-Health-IRP-rounds-Apr-25.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220422T110000
DTEND;TZID=America/Vancouver:20220422T120000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185511Z
UID:3744-1650625200-1650628800@www.centreforbrainhealth.ca
SUMMARY:Dr. Pascal Kaeser: Mechanisms and Roles for Fast Dopamine Signaling
DESCRIPTION:Dopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I will present data on triggering mechanisms of dopamine release and evaluate its roles in striatal regulation. In the long-term\, our work will allow for a better understanding of the mechanisms and time scales of dopamine coding in health and disease. \n“Live Screening” in Rudy North Lecture Theatre\nZoom details if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-pascal-kaeser/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220408T120000
DTEND;TZID=America/Vancouver:20220408T130000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185332Z
UID:3743-1649419200-1649422800@www.centreforbrainhealth.ca
SUMMARY:Dr. Shigeki Watanabe: Ultrafast recycling of synaptic vesicles
DESCRIPTION:In 1973 John Heuser and Tom Reese demonstrated that neurotransmitter was released from neurons via the fusion of neurotransmitter-filled vesicles with the cell membrane.  But at the same time\, these experiments launched a controversy that is unresolved today – do vesicles collapse into the membrane and are then recycled slowly on the order of 20 seconds? Or do they retain their existence – and reverse the pore in just 1 second\, as proposed in ‘kiss and run’ endocytosis?  Since then\, molecular pathways for fusion and recycling have been put forward\, but the field remains divided.  We have used channelrhodopsin to stimulate neurons in intact nematodes and in cultured hippocampal neurons.  The specimen is then frozen 15 ms to 20 seconds after the stimulus. To our surprise\, we observed a different form of vesicle recycling that is ultrafast\, in which membrane is endocytosed at lateral edges of active zones between 30-100 ms after stimulation.  The large endocytic vesicles then fuse to form an endosome and are resolved by clathrin into synaptic vesicles. Although rapid\, several molecules coordinately mediate ultrafast endocytosis. I will discuss the findings from the original studies and our current work on molecular mechanisms underlying ultrafast endocytosis. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-shigeki-watanabe/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220401T110000
DTEND;TZID=America/Vancouver:20220401T120000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220414T185300Z
UID:3742-1648810800-1648814400@www.centreforbrainhealth.ca
SUMMARY:Dr. Bojana Stefanovic: Neurovascular unit dysfunction in a model of TBI
DESCRIPTION:Mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury globally. Although its consequences may be short term\, mTBI often leads to long-term neuropsychiatric and neurological impairments and has been estimated to increase the probability of later life dementia up to six-fold. It is presently not clear what neuropathological changes underlie these deficits. This talk will review our recent studies on the sustained neurogliovascular unit function changes in a murine model of repeated\, mild traumatic brain injury. By leveraging two photon fluorescence microscopy\, intracerebral electrophysiological recordings\, optogenetics\, high field magnetic resonance imaging\, and light sheet fluorescence microscopy\, we reveal pronounced\, lasting\, and diffuse changes in the neuronal and cerebrovascular functional signals in situ\, accompanied by only subtle changes in histopathological readouts and no changes on conventional neuroimaging. Our studies suggest the potential of disinhibitory interventions to ameliorate peri-contusional neuronal and cerebrovascular tone and reactivity. In light of known import of functional hyperemia for healthy brain functioning\, normalization of the neurovascular unit function is likely key for decreasing the susceptibility of the concussed brain to subsequent pathologies. We expect sensitive in situ functional assays to be instrumental for development of such neurovascularly targeted interventions in the clinic. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-bojana-stefanovic/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220328T154500
DTEND;TZID=America/Los_Angeles:20220328T170000
DTSTAMP:20231124T144053
CREATED:20220318T182227Z
LAST-MODIFIED:20220415T003543Z
UID:8593-1648482300-1648486800@www.centreforbrainhealth.ca
SUMMARY:Heart rate variability (HRV) correlates of functional MRI in humans
DESCRIPTION:This month\, Komal Bharti from the Vila-Rodriguez lab in the Department of Psychiatry will present on “Heart rate variability (HRV) correlates of functional MRI in humans.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/heart-rate-variability-correlates-of-functional-mri-in-humans/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/03/Mental-Health-IRP-rounds-Mar-28.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220325T110000
DTEND;TZID=America/Vancouver:20220325T120000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220304T235814Z
UID:3741-1648206000-1648209600@www.centreforbrainhealth.ca
SUMMARY:Dr. Edward F. Chang: Towards a Speech Neuroprosthetic
DESCRIPTION:Speaking is a unique and defining human behavior.  Over the past decade\, we have focused on deciphering the basic neural code that underlies our ability to speak fluently. \nDuring speech production\, vocal tract movement gestures for all speech sounds are encoded by highly specialized neural activity\, organized as a map\, in the human speech motor cortex.   A major effort is now underway to translate these findings towards building an articulatory-based speech neuroprosthetic device for people who cannot communicate. \n\n\n\nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-edward-f-chang/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220321T110000
DTEND;TZID=America/Los_Angeles:20220321T120000
DTSTAMP:20231124T144053
CREATED:20220224T010946Z
LAST-MODIFIED:20220225T205037Z
UID:8314-1647860400-1647864000@www.centreforbrainhealth.ca
SUMMARY:Majid Mohajerani candidate presentation
DESCRIPTION:Spontaneous activity accounts for most of what the brain does and is likely to be key for information processing in the brain\, but its function is still quite mysterious. Two key spontaneous activity processes are the Default Mode Network (DMN)\, a set of areas that are most markedly connected and active during behavioural idleness\, and memory replay\, the spontaneous reactivation of neural patterns occurring during experience. In the Mohajerani lab\, we test the hypothesis that the DMN plays a key role in memory replay processes. This theory\, if confirmed\, would bring important conceptual advances: to memory studies\, as it would provide a mechanism supporting the formation and consolidation of complex memory representations. I will explore this theory by our ongoing studies of neural activity over the whole mouse cortex in animals running memory tasks. \nZoom link if unable to attend in person: https://ubc.zoom.us/\nMeeting ID: 92458 122636 \nPasscode: 122636  \nFeedback survey for candidate
URL:https://www.centreforbrainhealth.ca/events/majid-mohajerani-candidate-presentation/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Majid-Mohajerani-SBME-candidate-talks.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220318T120000
DTEND;TZID=America/Vancouver:20220318T130000
DTSTAMP:20231124T144053
CREATED:20220223T230149Z
LAST-MODIFIED:20220318T232420Z
UID:8292-1647604800-1647608400@www.centreforbrainhealth.ca
SUMMARY:Science Communication Career Workshop
DESCRIPTION:Are you interested in science communication as a career but aren’t sure how to make it happen? Join the Djavad Mowafaghian Centre for Brain Health and the Women’s Health Research Cluster on March 18th\, from 12-1pm to learn more! This event will feature a panel of three science communicators\, all with diverse backgrounds\, who will be sharing their insights and experience in their science communication journey. This event is open to anyone who is interested in learning more about a career in scicomm.  \n  \nRSVP:\nPlease RSVP and include any questions for the panelists: RSVP HERE \nThis event will be held online: Zoom link \n  \nSpeakers:\n \nKate Shingler\nKate Shingler is a skilled communications professional with a penchant for strong espresso and Irish mystery novels. Kate began her career as a journalist at the Sherbrooke Record before moving to the broadcast realm as a local television reporter in Quebec City. She spent a decade at Global TV\, covering daily news\, as a show producer for the noon and evening news and as assistant news director of Global Montreal before moving on to work in public relations for non-profits close to her heart. She led the digital communications team at the McGill University Health Centre Foundation\, where she worked to support the hospital’s priorities and raise funds for compassionate patient care\, excellence in teaching and innovative research. \nIn 2020 Kate joined Brain Canada Foundation as Director of Marketing and Communications\, where she uses impact storytelling\, creative team building and community engagement to underline the critical need for investment in brain research in Canada. One in three Canadians will experience a brain disorder in their lifetime\, and one in five will experience a mental illness or addiction concern. With Brain Canada’s one brain-one community approach\, Kate is a proud member of a dedicated group of individuals committed to accelerating neuroscience across the country for global impact. \nKate is an active community volunteer with a commitment to supporting children in underserved populations. She sits on the boards of the Fraser-Hickson Institute and the Weredale Foundation\, and lives in Montreal with her husband\, their three children and a small dog named Charlotte. \nConnect with Kate on social media! \n\nTwitter\nLinkedIn\n\n  \n \nNoeen Malik\nNoeen Malik\, PhD\, is the nuclear medicine scientist (specialization: drug discovery and PET/CT imaging)\, a published author (The PET Method: Tracer Principle\, Radiochemistry and Medical Applications); business strategist (specialization: Theragnostics)\, Executive Director of Public Affairs at GIANT (Global Immunization Action Networking Team; with WHO-UN)\, California\, and Research Scientist in MIPS\, Stanford School of Medicine. \nShe also volunteers as a human rights activist (Amnesty International\, IRC (International rescue committee)\, and IYC-UN) and fundraiser (SOS Children’s Village). She has also started a philanthropy program under Scientudio’s umbrella\, “Endorse Hope“\, with focusing especially on under-developed countries to help in strengthening the internal personnel-capacities. She is also a cartoonist (Science Myths Playing Deck: Concept and artwork) and science illustrator and communicator. \nConnect with Noeen on social media! \n\nTwitter\nLinkedIn\n\n  \n \nAarthi Gobinath\nAarthi Gobinath is currently a Associate Scientific Director at MedThink SciCom\, supporting medical communications for pharmaceutical companies developing therapeutics for infectious diseases and rare diseases. Previously\, she worked as a Science Writer for the medical device company Ava Women and as a freelance writer. She completed her PhD in Neuroscience at the University of British Columbia\, where she initially began gaining experience and interest in science communication. \nConnect with Aarthi on social media! \n\nTwitter\nLinkedIn
URL:https://www.centreforbrainhealth.ca/events/science-communication-career-workshop/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Sci-Comms-Career-Workshop-Twitter-General.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220318T110000
DTEND;TZID=America/Vancouver:20220318T120000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220304T235750Z
UID:3740-1647601200-1647604800@www.centreforbrainhealth.ca
SUMMARY:Dr. Kate Wassum: Amygdala circuitry in reward learning and decision making
DESCRIPTION:To make adaptive decisions we must cast ourselves into the future and consider the outcomes of our potential choices. This prospective consideration is informed by our memories. I will discuss our lab’s recent work investigating the neural circuits responsible for encoding\, updating\, and retrieving reward memories for use in the considerations underlying decision making. We have taken a multifaceted approach to these investigations\, combining recording\, modern circuit dissection\, and behavioral tools. Our results are generally indicating that the basolateral amygdala\, midbrain\, and orbitofrontal cortex work in a circuit to participate in these functions. The cognitive symptoms underlying many psychiatric disorders result from a failure to appropriately learn about and/or anticipate potential future events\, making these basic science data relevant to the understanding and potential treatment of mental illness. \nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-kate-wassum/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220314T110000
DTEND;TZID=America/Los_Angeles:20220314T120000
DTSTAMP:20231124T144053
CREATED:20220223T010619Z
LAST-MODIFIED:20220224T201042Z
UID:8311-1647255600-1647259200@www.centreforbrainhealth.ca
SUMMARY:Tatsuya Tsukahara candidate presentation
DESCRIPTION:To interpret the sensory world and select appropriate actions\, animals must distinguish persistent background stimuli from novel sensory cues. Sensory adaptation is a neural mechanism that enables such filtering of environmental stimuli\, and a fundamental feature of sensory systems. Previous studies have shown that the brain flexibly adapt sensory responses to repetitive stimuli through synaptic mechanisms on a timescale of minutes. On the other hand\, the periphery has been generally thought to report sensory information stably and faithfully to the brain\, except for fast adaptation to highly dynamic stimuli on a timescale of milliseconds to seconds. However\, adaptation over longer timescales like hours to days have been largely unexplored\, even though animals typically stay in the same environment over these ethologically relevant timescales. \nI asked if olfactory sensory neurons (OSNs) in the mouse nose adapt to environmental stimuli over timescales of hours to days. Given each mouse OSN expresses only one odorant receptor out of more than 1\,000\, individual receptor-defined OSN subtypes experience a wide range of odor-evoked activity in each environment. Using single cell RNA-sequencing\, I showed that each of the ~1\,000 OSN subtypes harbors a distinct transcriptome whose content is precisely determined by interactions between its expressed odorant receptor and the environment. This transcriptional variation is systematically organized to support sensory adaptation: expression levels of more than 70 genes relevant to transforming odors into spikes continuously vary across OSN subtypes\, dynamically adjust to new environments over hours\, and accurately predict acute OSN-specific odor responses. Importantly\, population-level odor codes delivered to the brain are also modulated by the environment\, as assessed by in vivo calcium imaging of OSN axons. The sensory periphery therefore separates salient signals from predictable background via a transcriptional mechanism whose moment-to-moment state reflects the past and constrains the future. I will further present my future research plan to study how signals from the external and internal world are integrated via transcriptional adaptation and influence the activity in central circuits and odor perception. This research program will provide support for a general model of how animals use individual experience to optimize neural functions and behavior. \nZoom link if unable to attend in person: https://ubc.zoom.us/\nMeeting ID: 91783 244698 \nPasscode: 244698 \nFeedback survey for candidate
URL:https://www.centreforbrainhealth.ca/events/tatsuya-tsukahara-candidate-presentation/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Tatsuya-Tsukahara-SBME-candidate-talks.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220311T110000
DTEND;TZID=America/Vancouver:20220311T120000
DTSTAMP:20231124T144053
CREATED:20210722T000000Z
LAST-MODIFIED:20220301T230646Z
UID:3739-1646996400-1647000000@www.centreforbrainhealth.ca
SUMMARY:Dr. Rutsuko Ito: Ventral hippocampal circuits and the arbitration of approach-avoidance conflict
DESCRIPTION:Approach-avoidance (AA) conflict resolution is a form of decision making that is fundamentally important for survival and requires the effective evaluation of affective stimuli or events with mixed outcomes (positive and negative). Despite the prevailing view of hippocampal involvement in learning and memory processes\, the hippocampus is also thought to be involved in the resolution of AA conflict by exaggerating the value of negative outcomes and increasing the tendency to avoid. Furthermore\, work from my laboratory has implicated the ventral\, but not the dorsal hippocampus\, in mediating affective processes involving learned AA conflict. In this talk\, I will be presenting a set of studies providing evidence of ventral hippocampal (vHPC) mediation of AA decision making when animals are exposed to affectively bivalent (conflicting) cues. I will also present chemogenetic evidence that the control over conflict-elicited AA  behaviours is subfield\, and pathway-specific\, with the investigation extending to the wider extrinsic connectivity of the vHPC with the lateral septum and ventral striatum. \nRudy North Lecture Theatre “Live” Screening\nZoom option if unable to attend in person: \n\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589
URL:https://www.centreforbrainhealth.ca/events/dr-rutsuko-ito/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220308T130000
DTEND;TZID=America/Los_Angeles:20220308T140000
DTSTAMP:20231124T144053
CREATED:20220223T005627Z
LAST-MODIFIED:20220224T200824Z
UID:8306-1646744400-1646748000@www.centreforbrainhealth.ca
SUMMARY:Danqing Zhu candidate presentation
DESCRIPTION:Gene therapy\, the delivery of genetic material to the cells of a patient for therapeutic benefit\, has been increasingly successful over the past decade. The most successful gene delivery vectors are based on adeno-associated viruses (AAV)\, a naturally derived protein-based and self-assembled ‘nanoparticle’. Although these natural ‘nanoparticles’ are safe and non-pathogenic\, they present several barriers that limit their efficacy in delivery as they were not evolved by nature for human therapeutic applications. Directed evolution\, a strategy involves the iterative genetic diversification of a molecule to create a gene pool and functional selection to isolate variants with optimal properties\, has thereby emerged as a powerful approach for re-evolving AAVs of novel and improved functions. In parallel\, recent advances in deep sequencing technologies allow millions of sequences to be assayed and used for training supervised machine learning (ML) models for prediction of protein properties. Using the combination of directed evolution and ML-guided design\, we have engineered ‘designer’ AAV variants with greatly improved packaging\, diversity\, and primary human brain infection capabilities. Specifically\, we have applied such method for developing AAVs that target a crucial cellular component of the central nervous system (CNS)\, microglia. As a brain-resident macrophage\, microglia unfortunately have been implicated in many neurological diseases\, such as Alzheimer’s disease\, Parkinson’s disease\, Huntington’s disease\, and others etc. Therefore\, genetically manipulating endogenous microglia is a promising therapeutic approach to counteract disease pathology. The extension of such integration of new technologies will have broad utility in the development of next-generation novel AAVs for therapeutic applications of many neurological diseases in the near future. \nZoom link if unable to attend in person: https://ubc.zoom.us/\nMeeting ID: 93332 470044 \nPasscode: 470044 \nFeedback survey for candidate
URL:https://www.centreforbrainhealth.ca/events/danqing-zhu-candidate-presentation/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/02/Danqing-Zhu-SBME-candidate-talks.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220302T080000
DTEND;TZID=UTC:20220302T130000
DTSTAMP:20231124T144053
CREATED:20220225T201732Z
LAST-MODIFIED:20220228T215632Z
UID:8346-1646208000-1646226000@www.centreforbrainhealth.ca
SUMMARY:BC Neuroscience Day
DESCRIPTION:Schedule:\n8:00 AM – PD Moyes Lecturer for 2022\nPresenter: Dr. Mojgan Hodaie\, MSc\, MD\, FRCSC\, Professor of Surgery\, University of Toronto\nTitle: “An artificial intelligence approach to the study of pain”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_ddmOwxdLlYF4IjI \n9:00 AM\nPresenter: Dr. Neil Cashman\, UBC Professor\, Medicine (Neurology)\nTitle: “Targeting misfolded proteins in neurodegenerative diseases”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_ePcLJdRy2O3b6oC \n10:00 AM\nPresenter: Dr. Cheryl Wellington\, UBC Professor\, Pathology and Laboratory Medicine\nTitle: “The biomarker revolution in neurology”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_bBi7PloMqqkOCLY \n11:00 AM\nPresenter: Dr. Annie Ciernia\, UBC Assistant Professor\, Department of Biochemistry and Molecular Biology\nTitle: “Histone Acetylation Regulates Microglia Innate Immune Memory”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_5prst2xqNGiXR8q \n12:00 PM\nPresenter: Dr. John Maguire\, UBC Professor\, Neuropathology\nTitle: “Clinical Pathological Correlation”\nEvaluation: https://ubc.ca1.qualtrics.com/jfe/form/SV_40EjWHbNZ45nyIu \n  \nLocation: Paetzold auditorium (JPPS 1891 LT) for those wishing to attend in person\, or online via Zoom: \nZoom link: https://ubc.zoom.us/\nMeeting ID: 91037 579420\nPasscode: 579420 \n  \nPlease email Dr. Cashman (Neil.Cashman@vch.ca) with inquiries regarding BC Neuroscience Day programming.
URL:https://www.centreforbrainhealth.ca/events/bc-neuroscience-day/
LOCATION:Paetzold Auditorium\, Vancouver General Hospital\, 899 West 12th Avenue\, Vancouver\, British Columbia\, V5Z 1M9\, Canada
END:VEVENT
END:VCALENDAR