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X-WR-CALNAME:Djavad Mowafaghian Centre for Brain Health | DMCBH
X-ORIGINAL-URL:https://www.centreforbrainhealth.ca
X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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TZID:America/Vancouver
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TZNAME:PDT
DTSTART:20230312T100000
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DTSTART:20231105T090000
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231208T150000
DTEND;TZID=America/Vancouver:20231208T160000
DTSTAMP:20231124T145333
CREATED:20231101T161224Z
LAST-MODIFIED:20231110T010326Z
UID:12173-1702047600-1702051200@www.centreforbrainhealth.ca
SUMMARY:Michelle Jung: Effects of maternal sucrose consumption during pregnancy on maternal and fetal glucocorticoids
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Michelle Jung from the Soma lab. \nZoom link: https://ubc.zoom.us/j/61318867702?pwd=VER4SC9FSGFzSW5TZHFKWi8vaUlEUT09 \nMeeting ID: 613 1886 7702\nPasscode: 1234 \n  \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/bns-michelle-jung/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231208T110000
DTEND;TZID=America/Vancouver:20231208T120000
DTSTAMP:20231124T145333
CREATED:20230511T164358Z
LAST-MODIFIED:20231124T105827Z
UID:10880-1702033200-1702036800@www.centreforbrainhealth.ca
SUMMARY:Dr. Adrienne Fairhall: Cognitive rule-switching in macaques.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nWhat is the neural basis of abstraction? Working in collaboration with experimental groups who have trained monkeys and humans on a decision task\, we analyze how subjects make use of visual information and feedback to infer a hidden rule\, where the rule switches in an uncued fashion. We fit a suite of behavioral models and learn that while humans are close to optimal Bayesian agents\, monkey behavior is better fit as reinforcement learning\, with a novel additional factor included. We use this behavioral model to elucidate structure in neural activity recorded from 200 sites across the brain\, finding low-dimensional and dynamic representations of stimulus\, feedback and  reward prediction error that support the notion of internal states captured by the behavioral model. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-adrienne-fairhall/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231201T150000
DTEND;TZID=America/Vancouver:20231201T160000
DTSTAMP:20231124T145333
CREATED:20231101T161101Z
LAST-MODIFIED:20231110T010233Z
UID:12171-1701442800-1701446400@www.centreforbrainhealth.ca
SUMMARY:Quincy Collins: Exploring embryonic microglial responsiveness to maternal stress during pregnancy
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Quincy Collins from the Rosin lab. \nZoom link: https://ubc.zoom.us/j/61318867702?pwd=VER4SC9FSGFzSW5TZHFKWi8vaUlEUT09 \nMeeting ID: 613 1886 7702\nPasscode: 1234 \n  \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/bns-quincy-collins/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231201T110000
DTEND;TZID=America/Vancouver:20231201T120000
DTSTAMP:20231124T145333
CREATED:20230404T192402Z
LAST-MODIFIED:20231022T181816Z
UID:10675-1701428400-1701432000@www.centreforbrainhealth.ca
SUMMARY:Dr. Mark Bevan: Dysregulation and rescue of subthalamic nucleus locomotor function in Huntington’s disease mice
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn this seminar I will focus on our recent studies on the role of the subthalamic nucleus in motor control and its dysregulation in movement disorders.  We found that 1) subthalamic locomotor encoding and gait are highly dysregulated in Q175 Huntington’s disease (HD) mice 2) analogous gait deficits could be generated in wild type mice through optogenetic manipulation of subthalamic activity 3) subthalamic locomotor encoding and gait could be rescued in HD mice through suppression of subthalamic mutant huntingtin expression. Together\, these findings argue that subthalamic activity normally optimizes movement\, whereas dysregulated subthalamic activity contributes to gait deficits in HD and is a potential target for therapeutic intervention.
URL:https://www.centreforbrainhealth.ca/events/dr-mark-bevan/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231127T153000
DTEND;TZID=America/Vancouver:20231127T170000
DTSTAMP:20231124T145333
CREATED:20231115T193606Z
LAST-MODIFIED:20231115T193752Z
UID:12262-1701099000-1701104400@www.centreforbrainhealth.ca
SUMMARY:Leveraging the UBC Community to Address the Opioid Crisis: A Chemist’s Perspective
DESCRIPTION:This month\, Dr. Glenn Sammis will present “Leveraging the UBC Community to Address the Opioid Crisis: A Chemist’s Perspective.” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/leveraging-the-ubc-community-to-address-the-opioid-crisis-a-chemists-perspective/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/11/Mental-Health-IRP-rounds-Nov-2023.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231124T150000
DTEND;TZID=America/Vancouver:20231124T160000
DTSTAMP:20231124T145333
CREATED:20231101T160940Z
LAST-MODIFIED:20231110T010058Z
UID:12169-1700838000-1700841600@www.centreforbrainhealth.ca
SUMMARY:Anna Mazurenko: Regional Variations in Steroidogenic Enzymatic Activity in Rat Placenta and Implications for Neurodevelopment
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Anna Mazurenko from the Soma lab. \nZoom link: https://ubc.zoom.us/j/61318867702?pwd=VER4SC9FSGFzSW5TZHFKWi8vaUlEUT09 \nMeeting ID: 613 1886 7702\nPasscode: 1234 \n  \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/bns-anna-mazurenko/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231124T110000
DTEND;TZID=America/Vancouver:20231124T120000
DTSTAMP:20231124T145333
CREATED:20230329T174100Z
LAST-MODIFIED:20231003T185618Z
UID:10614-1700823600-1700827200@www.centreforbrainhealth.ca
SUMMARY:Dr. Irene Vavasour: Diving into neuroimaging research with FINS
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe Fipke Integrated Neuroimaging Suite (FINS) hosts state-of-the-art neuroimaging equipment including a 3T Philips MRI scanner and a 3T GE PET/MR scanner. Our translational research includes developing better imaging tools for disorders such as multiple sclerosis\, Parkinson’s\, Alzheimer’s\, stroke\, traumatic brain injury and mental health\, as well as healthy aging. This presentation will discuss many of our novel imaging techniques\, including myelin water imaging\, how and why they are used and what up and coming developments are available.
URL:https://www.centreforbrainhealth.ca/events/dr-irene-vavasour/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231117T150000
DTEND;TZID=America/Vancouver:20231117T160000
DTSTAMP:20231124T145333
CREATED:20231101T160724Z
LAST-MODIFIED:20231110T010001Z
UID:12167-1700233200-1700236800@www.centreforbrainhealth.ca
SUMMARY:Menghao Lu: The functions of CaMKII and PKC in Wnt-dependent neurite pruning
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Menghao Lu from the Mizumoto lab. \nZoom link: https://ubc.zoom.us/j/61318867702?pwd=VER4SC9FSGFzSW5TZHFKWi8vaUlEUT09 \nMeeting ID: 613 1886 7702\nPasscode: 1234 \n  \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/bns-menghao-lu/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231117T110000
DTEND;TZID=America/Vancouver:20231117T120000
DTSTAMP:20231124T145333
CREATED:20230329T173920Z
LAST-MODIFIED:20230829T165650Z
UID:10612-1700218800-1700222400@www.centreforbrainhealth.ca
SUMMARY:Dr. Rosemary Bagot:  At the intersection of threat and reward in nucleus accumbens glutamatergic afferents.
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe nucleus accumbens integrates diverse inputs\, balancing threat and reward to orchestrate motivated behaviour. Glutamatergic projections from the ventral hippocampus and medial prefrontal cortex converge in the accumbens medial shell and are implicated in reward processing as well as adaptation to chronic stress. How these pathways integrate aversive or appetitive events to modulate behaviour is not fully understood and largely unstudied in females\, despite known sex-differences in stress-related psychopathologies. I will present new data using pathway-specific in vivo fibre-photometry and chemogenetic silencing to uncover how these projections encode aversive experiences to shape behavioural responding to threat and integrate information about the outcome of actions to shape learning about reward.
URL:https://www.centreforbrainhealth.ca/events/dr-rosemary-bagot/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231103T150000
DTEND;TZID=America/Vancouver:20231103T160000
DTSTAMP:20231124T145333
CREATED:20231031T221052Z
LAST-MODIFIED:20231031T233905Z
UID:12161-1699023600-1699027200@www.centreforbrainhealth.ca
SUMMARY:BNS - Skylar Fang
DESCRIPTION:Join us for the UBC Behavioural Neuroscience Seminars (BNS)\, a lecture series featuring DMCBH trainees and professors in a casual setting. Talks take place from 3-4 pm every Friday in DMCBH 3402A-C and on Zoom. RSVP is not required. \nThis week’s speaker is Skylar Fang from the Madhav lab. \nZoom link: https://ubc.zoom.us/j/61318867702?pwd=VER4SC9FSGFzSW5TZHFKWi8vaUlEUT09 \nMeeting ID: 613 1886 7702\nPasscode: 1234 \n  \nIf you would like to be added to the mailing list to receive reminders each week\, please email Melody Salehzadeh (msalehzadeh@zoology.ubc.ca) and/or Jackson Schumacher (schumacher@psych.ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/bns-skylar-fang/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Behavioural Neuroscience Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231103T110000
DTEND;TZID=America/Vancouver:20231103T120000
DTSTAMP:20231124T145333
CREATED:20230424T173144Z
LAST-MODIFIED:20231016T194129Z
UID:10765-1699009200-1699012800@www.centreforbrainhealth.ca
SUMMARY:Dr. Douglas Wylie: Cerebellar Control of Flight in Birds: Easy as 1\, 2\, 3
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe cerebellum contains the majority of neurons in the brain and has been implicated with many aspects of motor control. In birds this includes the control of flight. In this talk\, by synthesizing behavioral\, neurophysiological\, neuroanatomical and paleontological data I will emphasize three points: (i) the expansion of the cerebellum in birds is associated with the evolution of powered flight; (ii) retinal-recipient nuclei that analyze optic flow are critical for controlling flight; and (iii) three different visuomotor areas of the cerebellum are involved in controlling different aspects of flight.
URL:https://www.centreforbrainhealth.ca/events/dr-douglas-wylie/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231023T153000
DTEND;TZID=America/Vancouver:20231023T170000
DTSTAMP:20231124T145333
CREATED:20231010T193025Z
LAST-MODIFIED:20231010T193025Z
UID:12056-1698075000-1698080400@www.centreforbrainhealth.ca
SUMMARY:Translational Research from a Clinician's Perspective: Focus on Substance Use and Concurrent Disorders
DESCRIPTION:Welcome back for a new season of MH&A rounds! \nThis month\, Dr. Christian Schütz  will present “Translational Research from a Clinician’s Perspective: Focus on Substance Use and Concurrent Disorders.” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/translational-research-from-a-clinicians-perspective-focus-on-substance-use-and-concurrent-disorders/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/10/Mental-Health-IRP-rounds-Oct-23-2023.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231020T110000
DTEND;TZID=America/Vancouver:20231020T120000
DTSTAMP:20231124T145333
CREATED:20220604T014558Z
LAST-MODIFIED:20230822T172646Z
UID:9072-1697799600-1697803200@www.centreforbrainhealth.ca
SUMMARY:Dr. Randy McIntosh: Hidden Repertoires in Cognitive Function and Dysfunction
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nA hidden repertoire is a functional configuration in the brain that supports behaviour but is seldom used. As a complex system\, the brain can show a broad range of configurations for the same function. This “many-to-one” property imparts our brain with resilience during normal operations but also in the face of adverse events\, such as damage or disease. I will cover the evidence for these repertoires and cover strategies for investigation\, and the implication for the I will also relate the existence of such repertoires to variations in the qualia of our experience.
URL:https://www.centreforbrainhealth.ca/events/dr-randy-mcintosh/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231013T110000
DTEND;TZID=America/Vancouver:20231013T120000
DTSTAMP:20231124T145333
CREATED:20220426T222843Z
LAST-MODIFIED:20230822T172608Z
UID:8924-1697194800-1697198400@www.centreforbrainhealth.ca
SUMMARY:Dr. Denise Cai: The brain in motion: stability and flexibility of memory engrams across time and experience
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nCreating stable memories is critical for survival. An animal relies on past learning to navigate its environment\, avoid dangerous situations\, and find needed resources. Because the environment is dynamic\, stable memories must be updated with new information to enable responses to changing threats (a specific danger) and rewards (such as food and water). The brain circuits involved in memory and learning require both stability and flexibility. Using in vivo calcium imaging and chemogenetics\, we demonstrate how new information is updated with past memories through co-reactivation of memory ensembles during offline periods including sleep.
URL:https://www.centreforbrainhealth.ca/events/dr-denise-cai/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231006T110000
DTEND;TZID=America/Vancouver:20231006T120000
DTSTAMP:20231124T145333
CREATED:20230921T193033Z
LAST-MODIFIED:20230921T193101Z
UID:11887-1696590000-1696593600@www.centreforbrainhealth.ca
SUMMARY:Dr. Julia Schulze-Hentrich: At the nexus of genes\, aging and environment: Understanding transcriptomic and epigenomic regulation in health and disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe DNA of every cell in our body contains the genes inherited from our parents and plays a crucial role in health and disease. While changes in the DNA itself are linked to monogenic diseases\, they often fail to explain complex disorders such as neurodegenerative diseases. This can potentially be explained by additional layers of gene regulation known to be stored “above” the DNA\, at the epigenetic level. Over the last years\, this relatively young research field has shown that molecular structures packaging DNA in the cell nucleus influence gene activity. The DNA itself as well as its packaging structure\, the so-called chromatin\, can be chemically modified in many ways and is highly dynamic. With these findings\, chromatin appears to be a central interface between genes and the environment\, and the development and progression of diseases could be decisively influenced by epigenetic changes. Our research group investigates which epigenetic modifications are associated with complex neurological diseases – in particular Parkinson’s and Huntington’s – and how environmental factors and aging have modulating effects on them. Here\, I will give an overview of current projects and highlight key findings of our work. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-julia-schulze-hentrich/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230929T110000
DTEND;TZID=America/Vancouver:20230929T120000
DTSTAMP:20231124T145333
CREATED:20220604T014843Z
LAST-MODIFIED:20230822T172524Z
UID:9076-1695985200-1695988800@www.centreforbrainhealth.ca
SUMMARY:Dr. Richard Mooney: From song to synapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nVocalizations are an essential medium for social and sexual signaling in mammals and birds.  Whereas most animals only produce innate vocalizations\, songbirds learn to sing in a process with many parallels to human speech learning. I will discuss recent advances from our lab highlighting the neural mechanisms that enable birdsong learning\, including basal ganglia-dependent vocal exploration and reinforcement. How the learned song is integrated with innate vocalizations will also be considered\, with reference to recent studies that genetically map neural circuits for innate vocalizations in mice. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-richard-mooney/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230925T153000
DTEND;TZID=America/Vancouver:20230925T170000
DTSTAMP:20231124T145333
CREATED:20230906T194413Z
LAST-MODIFIED:20230906T194413Z
UID:11776-1695655800-1695661200@www.centreforbrainhealth.ca
SUMMARY:Depressive and anxiety levels in a community sample: Examining the role of avoidance and reward-seeking behaviours
DESCRIPTION:Welcome back for a new season of MH&A rounds! \nThis month\, Ryan Tomm from the Todd lab will present “Depressive and anxiety levels in a community sample: Examining the role of avoidance and reward-seeking behaviours.” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/depressive-and-anxiety-levels-in-a-community-sample-examining-the-role-of-avoidance-and-reward-seeking-behaviours/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/09/Mental-Health-IRP-rounds-Sept-25-2023.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230922T110000
DTEND;TZID=America/Vancouver:20230922T120000
DTSTAMP:20231124T145333
CREATED:20230725T202300Z
LAST-MODIFIED:20230822T172441Z
UID:11438-1695380400-1695384000@www.centreforbrainhealth.ca
SUMMARY:Dr. Jibran Khokhar: Cannabis and the Vulnerable Brain: A Closer Look at Genetics\, Adolescence\, and Edible Overdose
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Khokhar will talk about the behavioural and neural correlates of various types of vulnerabilities to cannabis\, starting from genetic risk for cannabis use\, to vaping in adolescence\, to the recent increases in edible overdoses in children and pets.
URL:https://www.centreforbrainhealth.ca/events/dr-jibran-khokhar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230915T110000
DTEND;TZID=America/Vancouver:20230915T120000
DTSTAMP:20231124T145333
CREATED:20220706T204712Z
LAST-MODIFIED:20230901T170859Z
UID:9251-1694775600-1694779200@www.centreforbrainhealth.ca
SUMMARY:Dr. Maya Koronyo: Retinal manifestations of Alzheimer’s disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe neural retina is a key organ for vision and visual processing. As a direct extension of the brain\, it emerges as a prominent site impacted by Alzheimer’s disease (AD).  The retina is the only CNS tissue not shielded by bone that can be easily accessible for noninvasive\, affordable\, ultra-high-resolution imaging in the clinical setting. Data from recent years strongly suggest it can serve as a window to assess AD. Early studies described retinal nerve fiber layer and ganglion cell degeneration. Our team revealed the accumulation of core AD hallmarks—amyloid β-protein (Aβ) plaques and neurofibrillary tangles—in the retina of AD and mild cognitive impairment (MCI) patients. Subsequent studies confirmed these findings\, and further reported visual and electroretinography abnormalities\, retinal tauopathy\, Aβ oligomers\, inflammation\, and cell-specific degeneration in AD patients. Data from our group and others suggest that the brain and retina follow a similar trajectory during AD progression\, potentially due to their shared embryonic origin and anatomical proximity. Moreover\, retinal vascular irregularities—vessel density and fractal dimensions\, blood flow\, foveal avascular zone\, curvature tortuosity\, arteriole-to-venule ratio—are present in AD patients\, including early-stage cases. A tight association between cerebral and retinal vasculopathy to cognitive deficits was reported in AD patients and animal models. More recently\, we identified early and progressive retinal vascular platelet-derived growth factor receptor-β (PDGFRβ) deficiency and pericyte loss\, as well as retinal endothelial tight junction losses in MCI and AD patients. These retinal vasculopathies strongly link to vascular amyloid accumulation as well as could predict the severity of cerebral amyloid angiopathy. Currently\, we explore the complex landscape of Alzheimer’s in the retina\, including AD-related molecular signatures and processes\, new forms of proteinopathies\, vascular and inflammatory abnormalities\, synaptic loss\, as well as cell-specific vulnerability and resilience. Establishing how early retinal biomarkers can be detected during AD continuum and what do they mean for brain pathology and functional decline\, should guide the development of future retinal imaging technologies to improve early\, noninvasive AD diagnosis and monitoring. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-maya-koronyo/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230908T110000
DTEND;TZID=America/Vancouver:20230908T120000
DTSTAMP:20231124T145333
CREATED:20220713T185639Z
LAST-MODIFIED:20230822T172316Z
UID:9307-1694170800-1694174400@www.centreforbrainhealth.ca
SUMMARY:Dr. Linda Overstreet-Wadiche: Adult-born neurons in the hippocampal network
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe adult dentate gyrus continually produces new neurons that integrate into the hippocampal circuit. Adult-born neurons transiently exhibit distinct cellular properties that distinguish them from the larger population of mature neurons\, and these properties are thought to underlie the vital role of neurogenesis in hippocampal behaviors. I will review the developmental trajectory of adult-born neuron cellular properties and present new data focused on cellular mechanisms of “critical periods” for plasticity and information processing. The results support the idea that neurogenesis provides a substrate for experience-dependent circuit plasticity and memory precision.
URL:https://www.centreforbrainhealth.ca/events/dr-linda-overstreet-wadiche-2/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230720T133000
DTEND;TZID=America/Vancouver:20230720T143000
DTSTAMP:20231124T145333
CREATED:20230707T200215Z
LAST-MODIFIED:20230714T175150Z
UID:11326-1689859800-1689863400@www.centreforbrainhealth.ca
SUMMARY:Dr. Barbara Sahakian: Good Brain Health\, Cognition and Wellbeing
DESCRIPTION:Dr. Barbara Sahakian from Cambridge University will be presenting: Good Brain Health\, Cognition and Wellbeing. \nTalk abstract: \nMany people consider their physical health and regularly exercise and wear devices to count their steps\, and to take other physiological measures. However\, to realise our potential throughout our life and to ensure a flourishing society\, it is important to focus on good brain health and wellbeing.  Environmental factors and our behaviour can improve our brains\, cognition and mental health or detract from it. Our diet\, our sleep and our social support systems are all key to improving brain health and cognition and reducing the risk of dementia. At the other end of the age spectrum\, social connectedness with friends and early reading can be beneficial for brain structure\, cognition and wellbeing in adolescence. One potential way to improve cognition is through cognitive training using games on iPads or mobile phones\, which has been shown to be beneficial for attention\, learning and memory in healthy people or patients with schizophrenia\, mild cognitive impairment (MCI) or stroke. \nBio: \nProfessor Barbara Sahakian is Professor of Clinical Neuropsychology in the Department of Psychiatry at the University of Cambridge. She is a Fellow of the British Academy and a Fellow of the Academy of Medical Sciences. She is a past president of the International Neuroethics Society and of the British Association for Psychopharmacology. According to Research.com she is one of the very top researchers worldwide in the fields of neuroscience and psychology. \nShe has over 550 publications in scientific journals\, including Science\, Nature and The Lancet. According to Google Scholar she has an h-index of 159. She has also been a leader in Government Policy on neuroscience and mental health\, including on the UK Government Foresight Project on “Mental Capital and Wellbeing” and has spoken in Davos at the World Economic Forum in 2014. \nShe has co-authored two popular science books published by Oxford University Press “Bad Moves: How Decision Making Goes Wrong and the Ethics of Smart Drugs” and “Sex\, Lies & Brain Scans”. “Sex\, Lies & Brain Scans” won the British Psychological Society Popular Book Award. She regularly writes for The Conversation. \nShe is co-Inventor of the Cambridge Cognition CANTAB computerized cognitive tests which are used around the world and the PEAK Wizard Memory Game and Decoder Attention and Concentration Game. She is also co-inventor of the EMOTICOM computerized tests of social and emotional cognition. \nProfessor Sahakian holds PhD and DSc degrees from the University of Cambridge. She is also a Clinical Psychologist. She is a Fellow of Clare Hall\, Cambridge. \nThis talk will be in person (Rudy North Lecture Theatre) and also via Zoom. \nZoom details: \n\nOpen https://ubc.zoom.us/ and click on ‘Join a Meeting’.\nMeeting ID: 91067 093313\nPasscode: 093313
URL:https://www.centreforbrainhealth.ca/events/dr-barbara-sahakian-good-brain-health-cognition-and-wellbeing/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230719T130000
DTEND;TZID=America/Vancouver:20230719T140000
DTSTAMP:20231124T145333
CREATED:20230707T195734Z
LAST-MODIFIED:20230714T175909Z
UID:11321-1689771600-1689775200@www.centreforbrainhealth.ca
SUMMARY:Dr. Trevor Robbins: The neural basis of compulsive behavior: Implications for neuropsychiatry
DESCRIPTION:Dr. Trevor Robbins from Cambridge University will be presenting: The neural basis of compulsive behavior: Implications for neuropsychiatry. \nTalk abstract: \nImpulsivity and compulsivity represent complementary cases of dysexecutive control\, of considerable relevance to psychiatry. Whilst there has been intense focus on the dimensional construct of impulsivity\, compulsivity has received far less attention. A working definition of compulsivity is of actions persisting inappropriate to the situation\, having no obvious relationship to the ultimate goal and often resulting in undesirable consequences. This definition can be dissected neuropsychologically in several ways which I will illustrate by describing behavioural\, computational and neuroimaging studies in two prototypical and devastating disorders of compulsivity\, stimulant drug addiction and obsessive-compulsive disorder (OCD). One notion is that compulsive behavior is uncontrolled and excessive habitual responding at the expense of adaptive goal-seeking behaviour. Habits are governed by stimulus-response representations that do not involve goals or rewards. These two forms of behavioural control have been characterized by studies in experimental animals and humans indicating mediation by distinct\, though interactive\, fronto-striatal systems. \nHypothetically\, addiction and OCD represent imbalance in these neural systems for goal-directed and habitual behaviour. I will examine several different ways of testing this hypothesis in stimulant drug abusers and patients with OCD and make comparisons indicating common\, as well as distinctive\, features of the two disorders. I will explore the implications of this research for causal accounts of behaviour including psychopathology\, new therapeutic approaches\, and the functional organization of fronto-striatal systems in the brain and their chemical neuromodulation. \nBio: \nTrevor Robbins was appointed in 1997 as the Professor of Cognitive Neuroscience at the University of Cambridge. He was formerly Professor of Experimental Psychology (and Head of Department) at Cambridge from October 2002-October 2017. He is also Director of the Behavioural and Clinical Neuroscience Institute (BCNI)\, jointly funded by the Medical Research Council and the Welcome Trust. The mission of the BCNI is to inter-relate basic and clinical research in psychiatry and neurology for such conditions as Parkinson’s\, Huntington’s\, and Alzheimer’s diseases\, frontal lobe injury\, schizophrenia\, depression\, drug addiction and developmental syndromes such as attention deficit/hyperactivity disorder. Trevor’s current research is focused on impulsive-compulsive disorders (such as OCD and drug addiction) and fronto-striatal systems of the brain. \nTrevor is a Fellow of the British Psychological Society (1990)\, British Pharmacological Society (2017)\, the Academy of Medical Sciences (2000) and the Royal Society (2005). He has been President of the European Behavioural Pharmacology Society (1992-1994) and he won that Society’s inaugural Distinguished Scientist Award in 2001. He was also President of the British Association of Psychopharmacology from 1996 to 1997. He has edited the journal Psychopharmacology since 1980 and joined the editorial board of Science in January 2003. He has been a member of the Medical Research Council (UK) and chaired the Neuroscience and Mental Health Board from 1995 until 1999. \nHe has been included on a list of the 100 most cited neuroscientists by ISI\, has published over 800 full papers in scientific journals and has co-edited eight books (Psychology for Medicine: The Prefrontal Cortex; Executive and Cognitive Function: Disorders of Brain and Mind 2:Drugs and the Future: The Neurobiology of Addiction; New Vistas. Decision-making\, Affect and Learning: Cognitive Search: Evolution\, Algorithms\, and the Brain; and Translational Neuropsychopharmacology). He was recently ranked as “the 4th most influential brain scientist of the modern era”. \nThis talk will be in person (Rudy North Lecture Theatre) and also via Zoom. \nZoom details: \n\nOpen https://ubc.zoom.us/ and click on ‘Join a Meeting’.\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/dr-trevor-robbins-the-neural-basis-of-compulsive-behavior-implications-for-neuropsychiatry/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230602T110000
DTEND;TZID=America/Vancouver:20230602T120000
DTSTAMP:20231124T145333
CREATED:20210722T000000Z
LAST-MODIFIED:20230412T180627Z
UID:3750-1685703600-1685707200@www.centreforbrainhealth.ca
SUMMARY:Dr. Hokto Kazama: Representations and circuits for opposing odor values in the brain
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nOdors are intrinsically associated with values ranging from positive to negative as they induce innate behaviors such as attraction and aversion. However\, how opposing\, innate values of odors are represented and computed in the brain remains unclear. We are addressing this question in the olfactory circuit of fruit fly Drosophila\, by combining a behavioral analysis in virtual reality\, an imaging technique to track the activity of effectively all the neurons in each brain region\, a connectome analysis\, and simulation. I will discuss our latest findings on distinct subcircuits in the higher-order region that possess different connectivity motifs and compute opposing values of odors.
URL:https://www.centreforbrainhealth.ca/events/dr-hokto-kazama/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230512T110000
DTEND;TZID=America/Vancouver:20230512T120000
DTSTAMP:20231124T145333
CREATED:20230109T181911Z
LAST-MODIFIED:20230404T190800Z
UID:10236-1683889200-1683892800@www.centreforbrainhealth.ca
SUMMARY:Dr. Christopher Pack: Cortical basis of visual learning\, fast and slow
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHubel & Wiesel famously showed that the adult visual cortex changes very little with experience\, and yet we are capable of learning to recognize new faces and places throughout our lives. I will describe recent work that examines the brain changes that accompany learning of a new visual stimulus or visual behaviour. Most changes occur slowly\, over days or weeks\, and these involve altered connections between visual cortex areas and higher-level cortical regions. Under appropriate conditions\, we can observe learning that is very fast\, on a time-scale of minutes\, despite involving similar brain circuits. I will discuss potential applications to visual perception in healthy subjects and rehabilitation following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-christopher-pack/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230505T110000
DTEND;TZID=America/Vancouver:20230505T120000
DTSTAMP:20231124T145333
CREATED:20220604T014752Z
LAST-MODIFIED:20230411T201632Z
UID:9074-1683284400-1683288000@www.centreforbrainhealth.ca
SUMMARY:Dr. Yingxi Lin: Active Neuronal Ensembles
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHow are transient experiences converted into long-lasting memories? How do experiences modify behaviors? How do similar experiences elicit drastically different behavioral responses in the healthy and disease states? These are some of the questions that drive the research in my lab. We particularly focus on the mechanisms underlying the reconfiguration of neural circuits following sensory and behavioral experiences that leads to functional adaptation. While we know in many cases the brain regions that are involved\, the identity of the neurons that encode the information and the particular information that is processed are not easy to determine with standard molecular or systems approaches. To overcome these challenges my lab has developed a new set of genetic tools that have enabled us to genetically identify neuronal ensembles activated by sensory and behavioral experiences\, uncover essential circuit components involved in different aspects of learning and memory\, and explore the mechanisms by which learning is specifically coupled to synaptic changes on these ensembles to achieve behavioral adaptation. My talk will highlight both published and ongoing studies in my lab. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-yingxi-lin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230428T110000
DTEND;TZID=America/Vancouver:20230428T120000
DTSTAMP:20231124T145333
CREATED:20220426T223214Z
LAST-MODIFIED:20230127T185916Z
UID:8926-1682679600-1682683200@www.centreforbrainhealth.ca
SUMMARY:Dr. Stuart Trenholm: A day in the life of a blind mouse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIt is well established that after vision loss\, capabilities of the other sensory systems can be enhanced. However\, particularly in animal models of vision loss\, little has been done to examine how vision loss leads to alterations in the ‘blind brain’\, and how these changes affect an animal’s behavior. Here I will discuss our recent work describing changes in neuronal activity and animal behaviour in mice following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-stuart-trenholm/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230424T153000
DTEND;TZID=America/Vancouver:20230424T170000
DTSTAMP:20231124T145333
CREATED:20230414T234132Z
LAST-MODIFIED:20230414T234132Z
UID:10723-1682350200-1682355600@www.centreforbrainhealth.ca
SUMMARY:Computational modeling of gambling in rats: bridging the gap between rodents and humans
DESCRIPTION:This month\, Clare Hales from the Winstanley lab will present “Computational modeling of gambling in rats: bridging the gap between rodents and humans.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/computational-modeling-of-gambling-in-rats-bridging-the-gap-between-rodents-and-humans/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/04/Mental-Health-IRP-rounds-Apr-24-2023.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230421T110000
DTEND;TZID=America/Vancouver:20230421T120000
DTSTAMP:20231124T145333
CREATED:20221025T210816Z
LAST-MODIFIED:20230411T233932Z
UID:9816-1682074800-1682078400@www.centreforbrainhealth.ca
SUMMARY:Dr. Jesse Jackson: Examining the anatomy\, physiology\, and function of claustrum-cortical neurons
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe claustrum is a small brain region forming dense synaptic connections with most of the cerebral cortex. However\, the function of this region remains a mystery. I will highlight recent work from our group mapping the connectivity of claustrum neurons and determining how these cells control distinct cortical modules to participate in cognitive functions such as memory.
URL:https://www.centreforbrainhealth.ca/events/dr-jesse-jackson/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230415T100000
DTEND;TZID=America/Vancouver:20230415T121500
DTSTAMP:20231124T145333
CREATED:20230328T214836Z
LAST-MODIFIED:20230329T203055Z
UID:10603-1681552800-1681560900@www.centreforbrainhealth.ca
SUMMARY:Brainstorm: Innovations and Breakthroughs
DESCRIPTION:Spend an interactive morning with some of UBC’s top researchers in areas such as healthy aging\, dementia\, mental health\, brain injury\, Parkinson’s disease and autism to learn how their research is improving the lives of British Columbians and what some of the next discoveries in brain health might be. \nSpeakers include: \n\nDr. Teresa Liu-Ambrose\, Healthy Aging\nDr. Mark Cembrowski\, Learning/Memory and Dementias\nDr. Cheryl Wellington\, Brain Injury and Repair\nDr. Fidel Vila-Rodriguez\, Mental Health and Addictions\nDr. Kurt Haas\, Brain Development and Neurodevelopmental Disorders\nDr. Silke Appel-Cresswell\, Sensory/Motor Systems and Movement Disorders\n\nRSVP\nIf you have any questions\, please reach out to Clement Woo (clement.woo@ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/brainstorm-innovations-and-breakthroughs/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/03/Brainstorm-community-engagement-event.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230414T110000
DTEND;TZID=America/Vancouver:20230414T120000
DTSTAMP:20231124T145333
CREATED:20220620T202725Z
LAST-MODIFIED:20230224T214943Z
UID:9135-1681470000-1681473600@www.centreforbrainhealth.ca
SUMMARY:Dr. Jared Young: Crossing the death valleys of the translational continuum: Coupling domain specificity with clinical sensitivity
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe vast majority of drugs fail when trying to go from animals to humans.  Some fields fail more than others\, with psychiatry being at the pinnacle of a competition no field wants to win.  Understanding behavior has been difficult enough\, delineating what went awry at the genetic and environmental level throughout development\, to give rise to a myriad of disorders characterized by their behavior – is there a haystack big enough for that one needle?  Then developing drugs targeting those mechanisms?  First and foremost it is our job to delineate neural mechanisms underlying normal behavior.  To do that\, we must utilize tasks with domain-task specificity\, wherein we are confident that the cognitive domain measured in animals matches that tested in humans.  We can validate these tasks\, examining their face\, predictive (including pharmacological)\, and neurobiological validities.  For treatment development\, we also need to make sure that it is a domain worth targeting – do patients exhibit deficient performance\, does the task have clinical sensitivity?  I will present data we have generated over the past two decades demonstrating this process\, how translational task-development can work in forward and reverse\, how working with clinicians enabled testing the clinical sensitivity of even some of the simplest tasks in rodents such as exploration\, and effortful motivation.  This work culminates in testing potential treatments that patients guide us toward\, such as cannabis for attenuating risk-taking in people with bipolar disorder.  Thus\, from potential pharmacotherapies\, more targeted treatments can be through this use of domain specificity in testing.
URL:https://www.centreforbrainhealth.ca/events/dr-jared-young/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
END:VCALENDAR