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X-WR-CALDESC:Events for Djavad Mowafaghian Centre for Brain Health | DMCBH
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20231006T110000
DTEND;TZID=America/Vancouver:20231006T120000
DTSTAMP:20231124T144504
CREATED:20230921T193033Z
LAST-MODIFIED:20230921T193101Z
UID:11887-1696590000-1696593600@www.centreforbrainhealth.ca
SUMMARY:Dr. Julia Schulze-Hentrich: At the nexus of genes\, aging and environment: Understanding transcriptomic and epigenomic regulation in health and disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe DNA of every cell in our body contains the genes inherited from our parents and plays a crucial role in health and disease. While changes in the DNA itself are linked to monogenic diseases\, they often fail to explain complex disorders such as neurodegenerative diseases. This can potentially be explained by additional layers of gene regulation known to be stored “above” the DNA\, at the epigenetic level. Over the last years\, this relatively young research field has shown that molecular structures packaging DNA in the cell nucleus influence gene activity. The DNA itself as well as its packaging structure\, the so-called chromatin\, can be chemically modified in many ways and is highly dynamic. With these findings\, chromatin appears to be a central interface between genes and the environment\, and the development and progression of diseases could be decisively influenced by epigenetic changes. Our research group investigates which epigenetic modifications are associated with complex neurological diseases – in particular Parkinson’s and Huntington’s – and how environmental factors and aging have modulating effects on them. Here\, I will give an overview of current projects and highlight key findings of our work. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-julia-schulze-hentrich/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230929T110000
DTEND;TZID=America/Vancouver:20230929T120000
DTSTAMP:20231124T144504
CREATED:20220604T014843Z
LAST-MODIFIED:20230822T172524Z
UID:9076-1695985200-1695988800@www.centreforbrainhealth.ca
SUMMARY:Dr. Richard Mooney: From song to synapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nVocalizations are an essential medium for social and sexual signaling in mammals and birds.  Whereas most animals only produce innate vocalizations\, songbirds learn to sing in a process with many parallels to human speech learning. I will discuss recent advances from our lab highlighting the neural mechanisms that enable birdsong learning\, including basal ganglia-dependent vocal exploration and reinforcement. How the learned song is integrated with innate vocalizations will also be considered\, with reference to recent studies that genetically map neural circuits for innate vocalizations in mice. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-richard-mooney/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230925T153000
DTEND;TZID=America/Vancouver:20230925T170000
DTSTAMP:20231124T144504
CREATED:20230906T194413Z
LAST-MODIFIED:20230906T194413Z
UID:11776-1695655800-1695661200@www.centreforbrainhealth.ca
SUMMARY:Depressive and anxiety levels in a community sample: Examining the role of avoidance and reward-seeking behaviours
DESCRIPTION:Welcome back for a new season of MH&A rounds! \nThis month\, Ryan Tomm from the Todd lab will present “Depressive and anxiety levels in a community sample: Examining the role of avoidance and reward-seeking behaviours.” \nZoom link if unable to attend in person:\nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/depressive-and-anxiety-levels-in-a-community-sample-examining-the-role-of-avoidance-and-reward-seeking-behaviours/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/09/Mental-Health-IRP-rounds-Sept-25-2023.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230922T110000
DTEND;TZID=America/Vancouver:20230922T120000
DTSTAMP:20231124T144504
CREATED:20230725T202300Z
LAST-MODIFIED:20230822T172441Z
UID:11438-1695380400-1695384000@www.centreforbrainhealth.ca
SUMMARY:Dr. Jibran Khokhar: Cannabis and the Vulnerable Brain: A Closer Look at Genetics\, Adolescence\, and Edible Overdose
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Khokhar will talk about the behavioural and neural correlates of various types of vulnerabilities to cannabis\, starting from genetic risk for cannabis use\, to vaping in adolescence\, to the recent increases in edible overdoses in children and pets.
URL:https://www.centreforbrainhealth.ca/events/dr-jibran-khokhar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230915T110000
DTEND;TZID=America/Vancouver:20230915T120000
DTSTAMP:20231124T144504
CREATED:20220706T204712Z
LAST-MODIFIED:20230901T170859Z
UID:9251-1694775600-1694779200@www.centreforbrainhealth.ca
SUMMARY:Dr. Maya Koronyo: Retinal manifestations of Alzheimer’s disease
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe neural retina is a key organ for vision and visual processing. As a direct extension of the brain\, it emerges as a prominent site impacted by Alzheimer’s disease (AD).  The retina is the only CNS tissue not shielded by bone that can be easily accessible for noninvasive\, affordable\, ultra-high-resolution imaging in the clinical setting. Data from recent years strongly suggest it can serve as a window to assess AD. Early studies described retinal nerve fiber layer and ganglion cell degeneration. Our team revealed the accumulation of core AD hallmarks—amyloid β-protein (Aβ) plaques and neurofibrillary tangles—in the retina of AD and mild cognitive impairment (MCI) patients. Subsequent studies confirmed these findings\, and further reported visual and electroretinography abnormalities\, retinal tauopathy\, Aβ oligomers\, inflammation\, and cell-specific degeneration in AD patients. Data from our group and others suggest that the brain and retina follow a similar trajectory during AD progression\, potentially due to their shared embryonic origin and anatomical proximity. Moreover\, retinal vascular irregularities—vessel density and fractal dimensions\, blood flow\, foveal avascular zone\, curvature tortuosity\, arteriole-to-venule ratio—are present in AD patients\, including early-stage cases. A tight association between cerebral and retinal vasculopathy to cognitive deficits was reported in AD patients and animal models. More recently\, we identified early and progressive retinal vascular platelet-derived growth factor receptor-β (PDGFRβ) deficiency and pericyte loss\, as well as retinal endothelial tight junction losses in MCI and AD patients. These retinal vasculopathies strongly link to vascular amyloid accumulation as well as could predict the severity of cerebral amyloid angiopathy. Currently\, we explore the complex landscape of Alzheimer’s in the retina\, including AD-related molecular signatures and processes\, new forms of proteinopathies\, vascular and inflammatory abnormalities\, synaptic loss\, as well as cell-specific vulnerability and resilience. Establishing how early retinal biomarkers can be detected during AD continuum and what do they mean for brain pathology and functional decline\, should guide the development of future retinal imaging technologies to improve early\, noninvasive AD diagnosis and monitoring. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-maya-koronyo/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230908T110000
DTEND;TZID=America/Vancouver:20230908T120000
DTSTAMP:20231124T144504
CREATED:20220713T185639Z
LAST-MODIFIED:20230822T172316Z
UID:9307-1694170800-1694174400@www.centreforbrainhealth.ca
SUMMARY:Dr. Linda Overstreet-Wadiche: Adult-born neurons in the hippocampal network
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe adult dentate gyrus continually produces new neurons that integrate into the hippocampal circuit. Adult-born neurons transiently exhibit distinct cellular properties that distinguish them from the larger population of mature neurons\, and these properties are thought to underlie the vital role of neurogenesis in hippocampal behaviors. I will review the developmental trajectory of adult-born neuron cellular properties and present new data focused on cellular mechanisms of “critical periods” for plasticity and information processing. The results support the idea that neurogenesis provides a substrate for experience-dependent circuit plasticity and memory precision.
URL:https://www.centreforbrainhealth.ca/events/dr-linda-overstreet-wadiche-2/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230720T133000
DTEND;TZID=America/Vancouver:20230720T143000
DTSTAMP:20231124T144504
CREATED:20230707T200215Z
LAST-MODIFIED:20230714T175150Z
UID:11326-1689859800-1689863400@www.centreforbrainhealth.ca
SUMMARY:Dr. Barbara Sahakian: Good Brain Health\, Cognition and Wellbeing
DESCRIPTION:Dr. Barbara Sahakian from Cambridge University will be presenting: Good Brain Health\, Cognition and Wellbeing. \nTalk abstract: \nMany people consider their physical health and regularly exercise and wear devices to count their steps\, and to take other physiological measures. However\, to realise our potential throughout our life and to ensure a flourishing society\, it is important to focus on good brain health and wellbeing.  Environmental factors and our behaviour can improve our brains\, cognition and mental health or detract from it. Our diet\, our sleep and our social support systems are all key to improving brain health and cognition and reducing the risk of dementia. At the other end of the age spectrum\, social connectedness with friends and early reading can be beneficial for brain structure\, cognition and wellbeing in adolescence. One potential way to improve cognition is through cognitive training using games on iPads or mobile phones\, which has been shown to be beneficial for attention\, learning and memory in healthy people or patients with schizophrenia\, mild cognitive impairment (MCI) or stroke. \nBio: \nProfessor Barbara Sahakian is Professor of Clinical Neuropsychology in the Department of Psychiatry at the University of Cambridge. She is a Fellow of the British Academy and a Fellow of the Academy of Medical Sciences. She is a past president of the International Neuroethics Society and of the British Association for Psychopharmacology. According to Research.com she is one of the very top researchers worldwide in the fields of neuroscience and psychology. \nShe has over 550 publications in scientific journals\, including Science\, Nature and The Lancet. According to Google Scholar she has an h-index of 159. She has also been a leader in Government Policy on neuroscience and mental health\, including on the UK Government Foresight Project on “Mental Capital and Wellbeing” and has spoken in Davos at the World Economic Forum in 2014. \nShe has co-authored two popular science books published by Oxford University Press “Bad Moves: How Decision Making Goes Wrong and the Ethics of Smart Drugs” and “Sex\, Lies & Brain Scans”. “Sex\, Lies & Brain Scans” won the British Psychological Society Popular Book Award. She regularly writes for The Conversation. \nShe is co-Inventor of the Cambridge Cognition CANTAB computerized cognitive tests which are used around the world and the PEAK Wizard Memory Game and Decoder Attention and Concentration Game. She is also co-inventor of the EMOTICOM computerized tests of social and emotional cognition. \nProfessor Sahakian holds PhD and DSc degrees from the University of Cambridge. She is also a Clinical Psychologist. She is a Fellow of Clare Hall\, Cambridge. \nThis talk will be in person (Rudy North Lecture Theatre) and also via Zoom. \nZoom details: \n\nOpen https://ubc.zoom.us/ and click on ‘Join a Meeting’.\nMeeting ID: 91067 093313\nPasscode: 093313
URL:https://www.centreforbrainhealth.ca/events/dr-barbara-sahakian-good-brain-health-cognition-and-wellbeing/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230719T130000
DTEND;TZID=America/Vancouver:20230719T140000
DTSTAMP:20231124T144504
CREATED:20230707T195734Z
LAST-MODIFIED:20230714T175909Z
UID:11321-1689771600-1689775200@www.centreforbrainhealth.ca
SUMMARY:Dr. Trevor Robbins: The neural basis of compulsive behavior: Implications for neuropsychiatry
DESCRIPTION:Dr. Trevor Robbins from Cambridge University will be presenting: The neural basis of compulsive behavior: Implications for neuropsychiatry. \nTalk abstract: \nImpulsivity and compulsivity represent complementary cases of dysexecutive control\, of considerable relevance to psychiatry. Whilst there has been intense focus on the dimensional construct of impulsivity\, compulsivity has received far less attention. A working definition of compulsivity is of actions persisting inappropriate to the situation\, having no obvious relationship to the ultimate goal and often resulting in undesirable consequences. This definition can be dissected neuropsychologically in several ways which I will illustrate by describing behavioural\, computational and neuroimaging studies in two prototypical and devastating disorders of compulsivity\, stimulant drug addiction and obsessive-compulsive disorder (OCD). One notion is that compulsive behavior is uncontrolled and excessive habitual responding at the expense of adaptive goal-seeking behaviour. Habits are governed by stimulus-response representations that do not involve goals or rewards. These two forms of behavioural control have been characterized by studies in experimental animals and humans indicating mediation by distinct\, though interactive\, fronto-striatal systems. \nHypothetically\, addiction and OCD represent imbalance in these neural systems for goal-directed and habitual behaviour. I will examine several different ways of testing this hypothesis in stimulant drug abusers and patients with OCD and make comparisons indicating common\, as well as distinctive\, features of the two disorders. I will explore the implications of this research for causal accounts of behaviour including psychopathology\, new therapeutic approaches\, and the functional organization of fronto-striatal systems in the brain and their chemical neuromodulation. \nBio: \nTrevor Robbins was appointed in 1997 as the Professor of Cognitive Neuroscience at the University of Cambridge. He was formerly Professor of Experimental Psychology (and Head of Department) at Cambridge from October 2002-October 2017. He is also Director of the Behavioural and Clinical Neuroscience Institute (BCNI)\, jointly funded by the Medical Research Council and the Welcome Trust. The mission of the BCNI is to inter-relate basic and clinical research in psychiatry and neurology for such conditions as Parkinson’s\, Huntington’s\, and Alzheimer’s diseases\, frontal lobe injury\, schizophrenia\, depression\, drug addiction and developmental syndromes such as attention deficit/hyperactivity disorder. Trevor’s current research is focused on impulsive-compulsive disorders (such as OCD and drug addiction) and fronto-striatal systems of the brain. \nTrevor is a Fellow of the British Psychological Society (1990)\, British Pharmacological Society (2017)\, the Academy of Medical Sciences (2000) and the Royal Society (2005). He has been President of the European Behavioural Pharmacology Society (1992-1994) and he won that Society’s inaugural Distinguished Scientist Award in 2001. He was also President of the British Association of Psychopharmacology from 1996 to 1997. He has edited the journal Psychopharmacology since 1980 and joined the editorial board of Science in January 2003. He has been a member of the Medical Research Council (UK) and chaired the Neuroscience and Mental Health Board from 1995 until 1999. \nHe has been included on a list of the 100 most cited neuroscientists by ISI\, has published over 800 full papers in scientific journals and has co-edited eight books (Psychology for Medicine: The Prefrontal Cortex; Executive and Cognitive Function: Disorders of Brain and Mind 2:Drugs and the Future: The Neurobiology of Addiction; New Vistas. Decision-making\, Affect and Learning: Cognitive Search: Evolution\, Algorithms\, and the Brain; and Translational Neuropsychopharmacology). He was recently ranked as “the 4th most influential brain scientist of the modern era”. \nThis talk will be in person (Rudy North Lecture Theatre) and also via Zoom. \nZoom details: \n\nOpen https://ubc.zoom.us/ and click on ‘Join a Meeting’.\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/dr-trevor-robbins-the-neural-basis-of-compulsive-behavior-implications-for-neuropsychiatry/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230602T110000
DTEND;TZID=America/Vancouver:20230602T120000
DTSTAMP:20231124T144504
CREATED:20210722T000000Z
LAST-MODIFIED:20230412T180627Z
UID:3750-1685703600-1685707200@www.centreforbrainhealth.ca
SUMMARY:Dr. Hokto Kazama: Representations and circuits for opposing odor values in the brain
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nOdors are intrinsically associated with values ranging from positive to negative as they induce innate behaviors such as attraction and aversion. However\, how opposing\, innate values of odors are represented and computed in the brain remains unclear. We are addressing this question in the olfactory circuit of fruit fly Drosophila\, by combining a behavioral analysis in virtual reality\, an imaging technique to track the activity of effectively all the neurons in each brain region\, a connectome analysis\, and simulation. I will discuss our latest findings on distinct subcircuits in the higher-order region that possess different connectivity motifs and compute opposing values of odors.
URL:https://www.centreforbrainhealth.ca/events/dr-hokto-kazama/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230512T110000
DTEND;TZID=America/Vancouver:20230512T120000
DTSTAMP:20231124T144504
CREATED:20230109T181911Z
LAST-MODIFIED:20230404T190800Z
UID:10236-1683889200-1683892800@www.centreforbrainhealth.ca
SUMMARY:Dr. Christopher Pack: Cortical basis of visual learning\, fast and slow
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHubel & Wiesel famously showed that the adult visual cortex changes very little with experience\, and yet we are capable of learning to recognize new faces and places throughout our lives. I will describe recent work that examines the brain changes that accompany learning of a new visual stimulus or visual behaviour. Most changes occur slowly\, over days or weeks\, and these involve altered connections between visual cortex areas and higher-level cortical regions. Under appropriate conditions\, we can observe learning that is very fast\, on a time-scale of minutes\, despite involving similar brain circuits. I will discuss potential applications to visual perception in healthy subjects and rehabilitation following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-christopher-pack/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230505T110000
DTEND;TZID=America/Vancouver:20230505T120000
DTSTAMP:20231124T144504
CREATED:20220604T014752Z
LAST-MODIFIED:20230411T201632Z
UID:9074-1683284400-1683288000@www.centreforbrainhealth.ca
SUMMARY:Dr. Yingxi Lin: Active Neuronal Ensembles
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nHow are transient experiences converted into long-lasting memories? How do experiences modify behaviors? How do similar experiences elicit drastically different behavioral responses in the healthy and disease states? These are some of the questions that drive the research in my lab. We particularly focus on the mechanisms underlying the reconfiguration of neural circuits following sensory and behavioral experiences that leads to functional adaptation. While we know in many cases the brain regions that are involved\, the identity of the neurons that encode the information and the particular information that is processed are not easy to determine with standard molecular or systems approaches. To overcome these challenges my lab has developed a new set of genetic tools that have enabled us to genetically identify neuronal ensembles activated by sensory and behavioral experiences\, uncover essential circuit components involved in different aspects of learning and memory\, and explore the mechanisms by which learning is specifically coupled to synaptic changes on these ensembles to achieve behavioral adaptation. My talk will highlight both published and ongoing studies in my lab. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-yingxi-lin/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230428T110000
DTEND;TZID=America/Vancouver:20230428T120000
DTSTAMP:20231124T144504
CREATED:20220426T223214Z
LAST-MODIFIED:20230127T185916Z
UID:8926-1682679600-1682683200@www.centreforbrainhealth.ca
SUMMARY:Dr. Stuart Trenholm: A day in the life of a blind mouse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIt is well established that after vision loss\, capabilities of the other sensory systems can be enhanced. However\, particularly in animal models of vision loss\, little has been done to examine how vision loss leads to alterations in the ‘blind brain’\, and how these changes affect an animal’s behavior. Here I will discuss our recent work describing changes in neuronal activity and animal behaviour in mice following vision loss.
URL:https://www.centreforbrainhealth.ca/events/dr-stuart-trenholm/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230424T153000
DTEND;TZID=America/Vancouver:20230424T170000
DTSTAMP:20231124T144504
CREATED:20230414T234132Z
LAST-MODIFIED:20230414T234132Z
UID:10723-1682350200-1682355600@www.centreforbrainhealth.ca
SUMMARY:Computational modeling of gambling in rats: bridging the gap between rodents and humans
DESCRIPTION:This month\, Clare Hales from the Winstanley lab will present “Computational modeling of gambling in rats: bridging the gap between rodents and humans.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/computational-modeling-of-gambling-in-rats-bridging-the-gap-between-rodents-and-humans/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/04/Mental-Health-IRP-rounds-Apr-24-2023.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230421T110000
DTEND;TZID=America/Vancouver:20230421T120000
DTSTAMP:20231124T144504
CREATED:20221025T210816Z
LAST-MODIFIED:20230411T233932Z
UID:9816-1682074800-1682078400@www.centreforbrainhealth.ca
SUMMARY:Dr. Jesse Jackson: Examining the anatomy\, physiology\, and function of claustrum-cortical neurons
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe claustrum is a small brain region forming dense synaptic connections with most of the cerebral cortex. However\, the function of this region remains a mystery. I will highlight recent work from our group mapping the connectivity of claustrum neurons and determining how these cells control distinct cortical modules to participate in cognitive functions such as memory.
URL:https://www.centreforbrainhealth.ca/events/dr-jesse-jackson/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230415T100000
DTEND;TZID=America/Vancouver:20230415T121500
DTSTAMP:20231124T144504
CREATED:20230328T214836Z
LAST-MODIFIED:20230329T203055Z
UID:10603-1681552800-1681560900@www.centreforbrainhealth.ca
SUMMARY:Brainstorm: Innovations and Breakthroughs
DESCRIPTION:Spend an interactive morning with some of UBC’s top researchers in areas such as healthy aging\, dementia\, mental health\, brain injury\, Parkinson’s disease and autism to learn how their research is improving the lives of British Columbians and what some of the next discoveries in brain health might be. \nSpeakers include: \n\nDr. Teresa Liu-Ambrose\, Healthy Aging\nDr. Mark Cembrowski\, Learning/Memory and Dementias\nDr. Cheryl Wellington\, Brain Injury and Repair\nDr. Fidel Vila-Rodriguez\, Mental Health and Addictions\nDr. Kurt Haas\, Brain Development and Neurodevelopmental Disorders\nDr. Silke Appel-Cresswell\, Sensory/Motor Systems and Movement Disorders\n\nRSVP\nIf you have any questions\, please reach out to Clement Woo (clement.woo@ubc.ca).
URL:https://www.centreforbrainhealth.ca/events/brainstorm-innovations-and-breakthroughs/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/03/Brainstorm-community-engagement-event.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230414T110000
DTEND;TZID=America/Vancouver:20230414T120000
DTSTAMP:20231124T144504
CREATED:20220620T202725Z
LAST-MODIFIED:20230224T214943Z
UID:9135-1681470000-1681473600@www.centreforbrainhealth.ca
SUMMARY:Dr. Jared Young: Crossing the death valleys of the translational continuum: Coupling domain specificity with clinical sensitivity
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nThe vast majority of drugs fail when trying to go from animals to humans.  Some fields fail more than others\, with psychiatry being at the pinnacle of a competition no field wants to win.  Understanding behavior has been difficult enough\, delineating what went awry at the genetic and environmental level throughout development\, to give rise to a myriad of disorders characterized by their behavior – is there a haystack big enough for that one needle?  Then developing drugs targeting those mechanisms?  First and foremost it is our job to delineate neural mechanisms underlying normal behavior.  To do that\, we must utilize tasks with domain-task specificity\, wherein we are confident that the cognitive domain measured in animals matches that tested in humans.  We can validate these tasks\, examining their face\, predictive (including pharmacological)\, and neurobiological validities.  For treatment development\, we also need to make sure that it is a domain worth targeting – do patients exhibit deficient performance\, does the task have clinical sensitivity?  I will present data we have generated over the past two decades demonstrating this process\, how translational task-development can work in forward and reverse\, how working with clinicians enabled testing the clinical sensitivity of even some of the simplest tasks in rodents such as exploration\, and effortful motivation.  This work culminates in testing potential treatments that patients guide us toward\, such as cannabis for attenuating risk-taking in people with bipolar disorder.  Thus\, from potential pharmacotherapies\, more targeted treatments can be through this use of domain specificity in testing.
URL:https://www.centreforbrainhealth.ca/events/dr-jared-young/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230331T110000
DTEND;TZID=America/Vancouver:20230331T120000
DTSTAMP:20231124T144504
CREATED:20210722T000000Z
LAST-MODIFIED:20230320T224544Z
UID:3747-1680260400-1680264000@www.centreforbrainhealth.ca
SUMMARY:Dr. Joseph Cheer: Endogenous cannabinoids and the pursuit of reward
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nIn the early stages of substance abuse\, subjects receive a drug that is highly reinforcing and are thus likely to repeat the actions that led them to obtain it.  This is termed positive reinforcement. However\, in a minority of people who develop an addiction phenotype\, negative reinforcement also causes a behavior to be repeated\, but in this case\, the action causes a bad feeling or situation to go away. The mesolimbic dopamine system\, which is thought to generate a teaching signal\, is involved in the selection of advantageous behavioral repertoires. This brain pathway is under control of endocannabinoid (eCBs)\, ubiquitous signaling molecules that bind to the same receptor targeted by marijuana (CB1) known to strengthen responses leading to the procurement of reward. Here\, we investigate how eCBs modulate dopaminergic encoding of cues predicting either\, appetitive stimuli\, the avoidance of punishment or aversive outcomes. We find that disrupting eCB signaling by treating animals with a CB1 receptor antagonist dose-dependently decreased concentrations of dopamine release in the nucleus accumbens that were time-locked to a warning signal that predicts avoidance of punishment while simultaneously weakening shock avoidance behavior\, effectively shifting the behavioral outcome from avoidance to escape. We further demonstrate\, using directed mutagenesis approaches\, that 2AG release from dopamine neurons in the midbrain is a canonical mechanism responsible for the pursuit of rewards. \nIt has been posited that compromised motivation in HD or “apathy” arises from a deficit in preparing for and initiating goal-directed behavior. Apathy is always the primary deficit in motivation associated with frontal-subcortical diseases such as HD. Indeed\, apathy may be a core feature of HD disease pathology itself. In many cases apathy follows a similar trajectory as motor symptom progression in PD\, although it can become prevalent before phenoconversion. It can be the result of several neurobiologically maladaptive systems\, including affective (flattening of emotional responsiveness)\, behavioral (reduced initiation of spontaneous behavior)\, and executive dysfunction (difficulty planning/executing). Thus\, motivational dysfunction in HD is a deficit primarily in preparation for motivated behavior that can have debilitating co-morbid consequences. \nGaps in knowledge \n\nLoss of striatal cannabinoid type 1 (CB1) receptors is a key pathogenic of several neurodegenerative diseases\, including HD.\nTreatment for metabolic syndrome with the CB1 receptor antagonist Rimonabant was halted by the FDA because of loss of motivation and depressive ideation.\nHD patients tend to smoke marijuana as a way to self-medicate and to prevent feelings of loneliness and helplessness.\nLoss of goal-directed behavior in HD is specific to the incentive value of the reinforcer.\nTreatment with indirect cannabinoid agonists profoundly increases operationally defined indices of motivation in normal animals and reverses apathy via dopaminergic mechanisms in mouse models of HD.\n\nTogether these data suggest that eCBs might modify distinct behavioral responses related to exteroceptive stimuli by modulating conditioned mesolimbic dopamine release events.  These findings suggest that therapies aimed at modifying tissue levels of eCBs may be used to prevent drug seeking driven by negative affective states or improve motivational indices in animal models of HD. \n 
URL:https://www.centreforbrainhealth.ca/events/dr-joseph-cheer/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230327T153000
DTEND;TZID=America/Vancouver:20230327T170000
DTSTAMP:20231124T144504
CREATED:20230320T224950Z
LAST-MODIFIED:20230320T232709Z
UID:10570-1679931000-1679936400@www.centreforbrainhealth.ca
SUMMARY:A Tale of Three Studies: Updates on rat behavioural studies evaluating chronic ropinirole\, cannabis\, and psychedelics
DESCRIPTION:This month\, Dr. Catharine Winstanley from the Department of Psychology will present “A Tale of Three Studies: Updates on rat behavioural studies evaluating chronic ropinirole\, cannabis\, and psychedelics.” Specifically\, she will be talking about: \n\nsome of her lab’s latest studies with ropinirole to model iatrogenic gambling disorder\nher lab’s forays into cannabis administration\, including vaped self-administration\nsome very new data showing improvements in decision-making caused by low dose psilocybin administration\n\nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/a-tale-of-three-studies-updates-on-rat-behavioural-studies-evaluating-chronic-ropinirole-cannabis-and-psychedelics/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/03/Mental-Health-IRP-rounds-Mar-27-2023.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230324T110000
DTEND;TZID=America/Vancouver:20230324T120000
DTSTAMP:20231124T144504
CREATED:20221201T201738Z
LAST-MODIFIED:20230117T213557Z
UID:10052-1679655600-1679659200@www.centreforbrainhealth.ca
SUMMARY:Dr. Kathleen Morrison: Role for chromatin remodeling in the lifelong consequences of pubertal adversity on the brain and behavior
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nPuberty and ensuing adolescence represent a time when the brain is rapidly developing and is sensitive to environmental stimuli. This lecture will discuss evidence that pubertal adversity puts females at risk for altered stress responding and maternal behavior later in life. Evidence will be presented that pubertal stress leads to an enduring programmatic event in the chromatin landscape in several brain regions\, which may underlie both the lasting transcriptomic and behavioral consequences of pubertal stress.
URL:https://www.centreforbrainhealth.ca/events/dr-kathleen-morrison/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230317T110000
DTEND;TZID=America/Vancouver:20230317T120000
DTSTAMP:20231124T144504
CREATED:20210722T000000Z
LAST-MODIFIED:20230109T182025Z
UID:3748-1679050800-1679054400@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael Drew: Hippocampal mechanisms of fear suppression and relapse
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nLearned fear often relapses after extinction\, suggesting that extinction training generates a new memory that coexists with the original fear memory. Recent work from our lab has identified the hippocampus as a region where such fear and extinction memories exist and compete for expression. In this talk I will discuss recent work in our lab in which we have used activity-dependent neural tagging in mice to identify\, manipulate\, and characterize the cellular mechanisms of these hippocampal fear and extinction memories. I will discuss (1) where in the hippocampus these memory representations exist\, (2) evidence that fear and extinction memories are coded by molecularly distinct cell ensembles\, and (3) evidence that expression of fear and extinction is mediated by activation unique hippocampal output pathways.
URL:https://www.centreforbrainhealth.ca/events/dr-michael-drew/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230310T110000
DTEND;TZID=America/Vancouver:20230310T120000
DTSTAMP:20231124T144504
CREATED:20220714T200422Z
LAST-MODIFIED:20230308T233026Z
UID:9317-1678446000-1678449600@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Neha Suvindran and Drs. Rebecca Todd & Stan Floresco
DESCRIPTION:Neha Suvindran: “Reimagining Neuro-Bioelectronic Systems: Sustainable\, Stable and Self-healing Fiber Electrodes”\nDrs. Rebecca Todd and Stan Floresco: “Translation Investigation of Neurophysiological Substrates of Active and inhibitory Avoidance in healthy and depressed populations.”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-neha-suvindran-and-rebecca-todd/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230303T110000
DTEND;TZID=America/Vancouver:20230303T120000
DTSTAMP:20231124T144504
CREATED:20220714T200002Z
LAST-MODIFIED:20230302T010113Z
UID:9315-1677841200-1677844800@www.centreforbrainhealth.ca
SUMMARY:UBC Kickstart Updates: Drs. Annie Ciernia and Paul van Donkelaar
DESCRIPTION:Dr. Annie Ciernia: “Mechanisms of Peripheral Lipopolysaccharide Induced Brain Inflammation”\nDr. Paul van Donkelaar: “Characterizing tau pathology in survivors of intimate partner violence-related traumatic brain injury”\nZoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258
URL:https://www.centreforbrainhealth.ca/events/ubc-kickstart-updates-drs-annie-ciernia-and-paul-van-donkelaar/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230227T153000
DTEND;TZID=America/Vancouver:20230227T170000
DTSTAMP:20231124T144504
CREATED:20230214T005826Z
LAST-MODIFIED:20230214T005826Z
UID:10442-1677511800-1677517200@www.centreforbrainhealth.ca
SUMMARY:Using fMRI to model representational content in a translational context
DESCRIPTION:This month\, Prof. Beck Todd from the Department of Psychology will present on “Using fMRI to model representational content in a translational context.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/using-fmri-to-model-representational-content-in-a-translational-context/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2023/02/Mental-Health-IRP-rounds-Feb-27-2023-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230224T110000
DTEND;TZID=America/Vancouver:20230224T120000
DTSTAMP:20231124T144504
CREATED:20220708T172733Z
LAST-MODIFIED:20230210T001332Z
UID:9281-1677236400-1677240000@www.centreforbrainhealth.ca
SUMMARY:Dr. Joni Wallis: Neuronal mechanisms of value-based decision-making: a brain-machine interface approach
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDecision-making is an unobservable cognitive process. This makes it challenging to investigate the underlying neuronal mechanisms. This lecture will discuss how techniques borrowed from the brain-machine interface field\, such as decoding population activity and closed-loop control\, can be used to understand how cognitive processes such as decision-making are implemented at the neuronal level. This approach could also lead to the development of novel devices for the treatment of neuropsychiatric disorders that involve impaired decision-making.
URL:https://www.centreforbrainhealth.ca/events/dr-joni-wallis/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230203T110000
DTEND;TZID=America/Vancouver:20230203T120000
DTSTAMP:20231124T144504
CREATED:20220704T174420Z
LAST-MODIFIED:20230105T182151Z
UID:9207-1675422000-1675425600@www.centreforbrainhealth.ca
SUMMARY:Dr. Anastassia Voronova: (Re)generating oligodendrocytes in the developing and degenerating brain: a neural stem cell perspective
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nObjectives: \n1) Neural stem cells build and regenerate the brain in part by forming oligodendrocytes\, the myelinating cells of the central nervous system \n2) Endogenous neural stem cells can be engaged in mouse models of neurodegenerative disorders for brain remyelination \n3) Neurodegenerative disorders may have a neurodevelopmental origin\, and neurodevelopmental disorders may have a neurodegenerative component.
URL:https://www.centreforbrainhealth.ca/events/dr-anatassia-voronova/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230127T123000
DTEND;TZID=America/Vancouver:20230127T133000
DTSTAMP:20231124T144504
CREATED:20230124T000707Z
LAST-MODIFIED:20230124T000707Z
UID:10298-1674822600-1674826200@www.centreforbrainhealth.ca
SUMMARY:Data Deposit Basics
DESCRIPTION:Please join us at Databinge on January 27th for “Data Deposit Basics” with Eugene Barsky. Eugene is the UBC Library’s Research Data Management Librarian and he will cover file naming\, folder structures\, README files\, metadata\, PIDs\, Data Management Plans and FAIR principles. \nContact Jeff LeDue (jledue@mail.ubc.ca) with any questions. \nZoom link
URL:https://www.centreforbrainhealth.ca/events/data-deposit-basics/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230120T110000
DTEND;TZID=America/Vancouver:20230120T120000
DTSTAMP:20231124T144504
CREATED:20220519T204558Z
LAST-MODIFIED:20230119T223200Z
UID:9022-1674212400-1674216000@www.centreforbrainhealth.ca
SUMMARY:Dr. Yuki Oka: Regulation of fluid homeostasis through gut-brain signaling
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nDr. Oka will discuss how innate instinct to consume water and salt is regulated through body-brain interactions.
URL:https://www.centreforbrainhealth.ca/events/dr-yuki-oka/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20230113T110000
DTEND;TZID=America/Vancouver:20230113T120000
DTSTAMP:20231124T144504
CREATED:20220519T204455Z
LAST-MODIFIED:20230109T182247Z
UID:9020-1673607600-1673611200@www.centreforbrainhealth.ca
SUMMARY:Dr. Susan Gauthier: Imaging a new treatment target in Multiple Sclerosis: Chronic Active Lesions
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 91512 289258\nPasscode: 289258\n\nInnate immunity plays a pivotal role in the pathophysiology of multiple sclerosis (MS) and important cell types involved in this process are CNS resident monocytes (microglia) and blood-derived macrophages. Chronic CNS inflammation in the MS lesion is maintained\, in part\, with iron-laden pro-inflammatory microglia/macrophages (m/M) at the rim of chronic active MS lesions. These lesions are felt to contribute to a more aggressive phenotype of the disease; thus\, represents a novel treatment target to reduce disease progression in MS. Identification of the subset of these lesions with a paramagnetic rim has been the focus of several in vivo studies evaluating the cross-sectional association of these lesions with disability\, however further work is required to advance the development of this potential treatment biomarker. Utilizing quantitative susceptibility mapping (QSM) to measure chronic active lesions\, our group has focused on generating tools to identify and quantify lesion-based chronic innate immune activity.  In this talk\, I will review imaging approaches to identify chronic lesion-based inflammation and the impact of chronic active lesions on the disease course. I will further propose a novel application of QSM to quantify the inflammatory trajectory within chronic active lesions and provide a new treatment target in MS for current or novel immune modulators
URL:https://www.centreforbrainhealth.ca/events/dr-susan-gauthier/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221209T110000
DTEND;TZID=America/Vancouver:20221209T120000
DTSTAMP:20231124T144504
CREATED:20220927T203729Z
LAST-MODIFIED:20221122T195911Z
UID:9656-1670583600-1670587200@www.centreforbrainhealth.ca
SUMMARY:Dr. Michael Kobor: Epigenetics and the Human Life Course
DESCRIPTION:Zoom option if unable to attend in person:\nZoom link here (click on “Join a meeting”)\nMeeting ID: 99412 188589\nPasscode: 188589\n\nDr. Michael Kobor is a Professor in the Department of Medical Genetics at the University of British Columbia (UBC) and The Edwin S.H. Leong UBC Chair in Healthy Aging—a UBC President’s Excellence Chair. He began his academic studies in his native Germany\, before coming to Canada to complete his PhD in Medical Genetics under Dr. Jack Greenblatt at the University of Toronto. He then completed postdoctoral training as a Human Frontier Science Program Fellow with Dr. Jasper Rine at the University of California\, Berkeley. Dr. Kobor has received many distinctions\, including a Tier 1 Canada Research Chair in Social Epigenetics\, the Sunny Hill BC Leadership Chair in Child Development\, and an appointment as Fellow of the Canadian Institute for Advanced Research (CIFAR) Child and Brain Development Program. A champion for translational research\, he previously served as the Director for the “Healthy Starts” Theme at BC Children’s Hospital Research Institute. He also leads the UBC Social Exposome Research Cluster\, an interdisciplinary effort spanning 8 Faculties that investigates the health effects of social and environmental factors and influences policies and interventions to reduce health disparities. Dr. Kobor is internationally recognized as a world-leader in the field of epigenetics and leads a program of research focused on illuminating the mechanisms by which environmental exposures and life experiences can “get under the skin” to persistently affect health and behaviour across the lifespan. \nObjectives \n\nTo learn about the importance and complexity of epigenetics across the human life course\nTo understand the various ways by which the epigenome can inform on human health and disease\nTo explore opportunities for collaborative research in human epigenetics and learn about the new Edwin S.H. Leong Healthy Aging Program at UBC
URL:https://www.centreforbrainhealth.ca/events/dr-michael-kobor/
LOCATION:Rudy North Lecture Theatre\, Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Neuroscience Research Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20221128T153000
DTEND;TZID=America/Vancouver:20221128T170000
DTSTAMP:20231124T144505
CREATED:20221104T234349Z
LAST-MODIFIED:20221104T234349Z
UID:9894-1669649400-1669654800@www.centreforbrainhealth.ca
SUMMARY:Abusing dopamine enhancing drugs: A case study
DESCRIPTION:This month\, Dr. Andrew Howard from the Neuropsychiatry group in the Department of Psychiatry will present on “Abusing dopamine enhancing drugs: A case study.” \nZoom link if unable to attend in person:  \nhttps://ubc.zoom.us/j/5747966049?pwd=N1ppY2tUS3o4bk9vTkFSTzBna3k0Zz09 \nMeeting ID: 574 796 6049\nPasscode: 052059
URL:https://www.centreforbrainhealth.ca/events/abusing-dopamine-enhancing-drugs-a-case-study/
LOCATION:DMCBH Room 3402\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 1Z3\, Canada
CATEGORIES:Monthly Monday Rounds in Mental Health and Addictions
ATTACH;FMTTYPE=image/jpeg:https://www.centreforbrainhealth.ca/wp-content/uploads/2022/11/Mental-Health-IRP-rounds-Nov-28-2022.jpg
END:VEVENT
END:VCALENDAR