Magnetic resonance imaging (MRI) scanners can be programmed to measure myelin, which is the insulating layer that protects neurons and is a key indicator of numerous neurological disorders. However, myelin imaging is extremely slow, traditionally requiring the MRI scanner to collect huge amounts of data. UBC researchers have developed a new technique that collects a tiny fraction of the data while providing higher-quality myelin measurements.
This new method developed by Dr. Adam Dvorak, under the supervision of Faculty of Medicine Associate Professor Dr. Shannon Kolind, is called the Constrained, Adaptive, Low-dimensional, Intrinsically Precise Reconstruction (CALIPR) framework. A recent study published in Science Advances examined the use of the CALIPR framework specifically in the context of myelin water imaging (MWI), which is a non-invasive technique used in quantitative MRI to measure the amount of myelin in the human body.
“Using this CALIPR technique, we can collect a tiny fraction of the imaging data — less than five per cent — but still reconstruct high-quality images,” says Dr. Dvorak, the study’s first author and recent PhD graduate in the Kolind lab. “Less data means less time lying in the scanner — in this case, more than 20 times less!”
The CALIPR technique allows for the acquisition of advanced, high-resolution quantitative maps of the human brain in 7.5 minutes, instead of 3 hours, making myelin imaging approximately 25 times faster than a conventional full MRI scan.
The new framework has demonstrated excellent precision in quantifying myelin content, with low variability in measurements for both the brain and the spinal cord. Compared to existing techniques, CALIPR is much more efficient and can potentially improve the detection of demyelinating diseases such as multiple sclerosis.
“If we compare an MRI image reconstruction to solving a multiple choice question, this technique does the equivalent of eliminating most of the incorrect options, making it much easier to solve.” Dr. Dvorak explains.
This technique, available for three different MRI manufacturers including a small, portable MRI scanner, may have broader applications in other quantitative MRI techniques and help revolutionize the treatment and care of a wide range of neurological disorders.